Results 101 to 110 of about 28,027 (244)

Pulm Pharmacol Ther [PDF]

Introduction:Hyperoxia-induced lung injury is characterized by acute alveolar injury, disrupted epithelial-mesenchymal signaling, oxidative stress, and surfactant dysfunction, yet currently, there is no effective treatment.

core  

Retinal venular constriction during hypercapnia in highlanders: The potential roles of oxygenation and occupational exposure

Experimental Physiology, EarlyView.
Faisal Ahsaan, Bakhtawar Latif, Aliza Akhtar   +2 more
wiley   +1 more source

The influence of metaboreflex activation on pulmonary pressure with combined chemoreflex activation in acute and chronic hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of both the metaboreflex via post‐exercise circulatory occlusion and the chemoreflex via acute and chronic hypoxia increased pulmonary artery systolic pressure. Coactivation of these reflexes further increased pulmonary artery pressure in an additive manner.
Lauren E. Maier, Elliott J. Jenkins, Andrew Douglas, Jack Talbot, Alexandra Williams, Jonathan Moore, Craig D. Steinback, Liam D. Corr, Zoe H. Adams, Fabio Giuseppe Laginestra, Markus Amann, Philip N. Ainslie, Travis D. Gibbons, Mike Stembridge   +13 more
wiley   +1 more source

Pulmonary apoptosis in aged and oxygen-tolerant rats exposed to hyperoxia

, 1998
Accumulating evidence demonstrates that genotoxic and oxidant stress can induce programmed cell death or apoptosis in cultured cells. However, little is known about whether oxidative stress resulting from the deleterious effects of hyperoxia can induce ...
Lin L. Mantell, Stuart Horowitz, Augustine M. K. Choi, Beek Yoke Chin, Leo E. Otterbein, Leah Stansberry   +5 more
core   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Inflammation and hyperoxia decreases MBP expression.

, 2012
A significantly decrease of MBP protein expression as a sign of hypomyelination occurs in all experimental settings with similar severity. Results of densitometric western blot quantification of P3 LPS P6 hyperoxia experiment (A), results of ...
Barbara S. Reinboth (121537), Julia Zimmermanns (121540), Sebastian Prager (121531), Daniela Brait (121550), Christoph Bührer (65653), Carina Mallard (121566), Felix Brehmer (121526), Ursula Felderhoff-Mueser (121569), Ivo Bendix (121528), Marco Sifringer (121555), Bettina Gerstner (121571), Stefanie Endesfelder (121559), Stéphane Sizonenko (121563), Gerald W. Schlager (121545), Yohan van de Looij (121534)   +14 more
core   +1 more source

The role of group III/IV afferent feedback in the ventilatory, pressor and metabolic responses to exercise in normoxia and hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Participants completed cycling exercise with (placebo) and without (25 µg intrathecal fentanyl) intact group III/IV muscle afferent feedback in three settings: normoxia, acute hypoxia and chronic hypoxia after 7–9 days of acclimatisation (∼3800 m). Blocking afferent feedback suppressed exercise hyperpnoea across all environments,
Elliott J. Jenkins, Phuong L. Ha, Connor A. Howe, Jay M. J. R. Carr, Justin A. Monteleone, Andrew J. M. Douglas, Abigail Nicholson, Andrew Steele, Brydie Lemkes, Jodie L. Koep, L. Madden Brewster, Jennifer Duffy, Mathew I. B. Debenham, Tena Monaghan, Declan Isaak, Jacob McCormick, Brian H. Dalton, Chris J. McNeil, Jared Baylis, David MacLeod, Mike Stembridge, Markus Amann, Philip N. Ainslie, Travis D. Gibbons   +23 more
wiley   +1 more source

Prominent role of exopeptidase DPP III in estrogen-mediated protection against hyperoxia in vivo

Redox Biology, 2016
A number of age-related diseases have a low incidence in females, which is attributed to a protective effect of sex hormones. For instance, the female sex hormone estrogen (E2) has a well established cytoprotective effect against oxidative stress, which ...
Sandra Sobočanec, Vedrana Filić, Mihaela Matovina, Dragomira Majhen, Željka Mačak Šafranko, Marijana Popović Hadžija, Željka Krsnik, Andrea Gudan Kurilj, Ana Šarić, Marija Abramić, Tihomir Balog   +10 more
doaj   +1 more source

CO2 chemoreflex contributions to ventilatory long‐term facilitation

The Journal of Physiology, EarlyView.
Abstract figure legend To determine whether changes in CO2 chemoreflex sensitivity contribute to ventilatory long‐term facilitation (LTF), we tested the hypothesis that hypercapnic acute intermittent hypoxia (AIH) induces ventilatory LTF and enhances peripheral, but not central, chemoreceptor CO2 chemoreflex sensitivity.
Susan V. Cross, Elizabeth Keen, Tom E. Nightingale, Zubair Ahmed, George M. Balanos, Joseph F. Welch   +5 more
wiley   +1 more source

Neonatal hyperoxia exposure leads to developmental programming of cardiovascular and renal disease in adult rats

Scientific Reports
Premature infants are often exposed to hyperoxia. However, there is limited data regarding the mechanistic underpinnings linking neonatal hyperoxia exposure and its contribution to cardio-renal dysfunction in adults born preterm.
Marissa J. DeFreitas, Elaine L. Shelton, Augusto F. Schmidt, Sydne Ballengee, Runxia Tian, PingPing Chen, Mayank Sharma, Amanda Levine, Emily Davidovic Katz, Claudia Rojas, Carolyn L. Abitbol, Juanita Hunter, Shathiyah Kulandavelu, Shu Wu, Karen C. Young, Merline Benny   +15 more
doaj   +1 more source