Results 11 to 20 of about 2,086,066 (301)

Understanding alveolarization to induce lung regeneration

Respiratory Research, 2018
Background Gas exchange represents the key physiological function of the lung, and is dependent upon proper formation of the delicate alveolar structure. Malformation or destruction of the alveolar gas-exchange regions are key histopathological hallmarks
José Alberto Rodríguez-Castillo, David Bravo Pérez, Aglaia Ntokou, Werner Seeger, Rory E. Morty, Katrin Ahlbrecht   +5 more
doaj   +1 more source

Effects of Hyperoxia on Mitochondrial Homeostasis: Are Mitochondria the Hub for Bronchopulmonary Dysplasia?

Frontiers in Cell and Developmental Biology, 2021
Mitochondria are involved in energy metabolism and redox reactions in the cell. Emerging data indicate that mitochondria play an essential role in physiological and pathological processes of neonatal lung development. Mitochondrial damage due to exposure
Yu Xuefei, Zhao Xinyi, Cai Qing, Zhang Dan, Liu Ziyun, Zheng Hejuan, Xue Xindong, Fu Jianhua   +7 more
doaj   +1 more source

PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors

eLife, 2022
The tips of the developing respiratory buds are home to important progenitor cells marked by the expression of SOX9 and ID2. Early in embryonic development (prior to E13.5), SOX9+progenitors are multipotent, generating both airway and alveolar epithelium,
Divya Khattar, Sharlene Fernandes, John Snowball, Minzhe Guo, Matthew C Gillen, Suchi Singh Jain, Debora Sinner, William Zacharias, Daniel T Swarr   +8 more
doaj   +1 more source

Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development. [PDF]

, 2015
BackgroundAdenomatous polyposis coli (Apc) is a tumor suppressor that inhibits Wnt/Ctnnb1. Mutations of Apc will not only lead to familial adenomatous polyposis with associated epithelial lesions, but will also cause aggressive fibromatosis in ...
Bellusci, Saverio, Chen, Hui, Chiu, Joanne, El Agha, Elie, Luo, Yongfeng, Menke, Douglas B, Qian, Bang-Ping, Shi, Wei, Turcatel, Gianluca, Warburton, David   +9 more
core   +1 more source

Molecular Nodal Restaging Based on CEACAM5, FGFR2b and PTPN11 Expression Adds No Relevant Clinical Information in Resected Non-Small Cell Lung Cancer

Journal of Investigative Surgery, 2022
Background The relapse rate in non-small cell lung cancer (NSCLC) is high, even in localized disease, suggesting that the current approach to pathological staging is insufficiently sensitive to detect occult micrometastases present in resected lymph ...
Ivan Macia, Gemma Aiza, Ricard Ramos, Ignacio Escobar, Francisco Rivas, Anna Ureña, Samantha Aso, Gabriela Rosado, Pau Rodriguez-Taboada, Carlos Deniz, Ernest Nadal, Gabriel Capella   +11 more
doaj   +1 more source

Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity [PDF]

, 2011
Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis.
Adamson IY, Artinian V, Aubry MC, Bai JW, Baumgartner KB, Berschneider B, Brody AR, Chen PP, Chilosi M, Chilosi M, Coalson JJ, Corrin B, Dasari V, Dissanayake SK, Dobbs LG, Flozak AS, Fukuda Y, Ha HY, Haddad R, Herzog EL, Hironaka M, Hu J, Huang CL, Hubbard R, Huber MA, Jayachandran A, Kasai H, Kasper M, Kato N, Kawasaki H, Kawasaki H, Kim J, Kim K, Kim KK, Kuwano K, Königshoff M, Königshoff M, Königshoff M, Lee JM, Liu L, Maher TM, Margalit O, Mason RJ, Matthay MA, Mazieres J, Melanie Königshoff, Moon RT, Nagai A, Pan LH, Park J, Pennison M, Plataki M, Qunn L, Radisky DC, Rosas IO, Sato M, Selman M, Selman M, Soon LL, Sternlicht MD, Thannickal VJ, Thiery JP, Uematsu K, Willis BC, Willis BC, Willis BC, Zavadil J   +66 more
core   +1 more source

Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia

Disease Models & Mechanisms, 2017
Progress in developing new therapies for bronchopulmonary dysplasia (BPD) is sometimes complicated by the lack of a standardised animal model. Our objective was to develop a robust hyperoxia-based mouse model of BPD that recapitulated the pathological ...
Claudio Nardiello, Ivana Mižíková, Diogo M. Silva, Jordi Ruiz-Camp, Konstantin Mayer, István Vadász, Susanne Herold, Werner Seeger, Rory E. Morty   +8 more
doaj   +1 more source

Epigenetic mechanisms in pulmonary arterial hypertension: the need for global perspectives

European Respiratory Review, 2016
Pulmonary arterial hypertension (PAH) is a severe and progressive disease, characterised by high pulmonary artery pressure that usually culminates in right heart failure. Recent findings of alterations in the DNA methylation state of superoxide dismutase
Prakash Chelladurai, Werner Seeger, Soni Savai Pullamsetti   +2 more
doaj   +1 more source

Deletion of Yy1 in mouse lung epithelium unveils molecular mechanisms governing pleuropulmonary blastoma pathogenesis

Disease Models & Mechanisms, 2020
Pleuropulmonary blastoma (PPB) is a very rare pediatric lung disease. It can progress from abnormal epithelial cysts to an aggressive sarcoma with poor survival.
Kim Landry-Truchon, Nicolas Houde, Mickaël Lhuillier, Louis Charron, Alice Hadchouel, Christophe Delacourt, William D. Foulkes, Louise Galmiche-Rolland, Lucie Jeannotte   +8 more
doaj   +1 more source

Current concepts on the role of inflammation in COPD and lung cancer [PDF]

, 2009
Chronic obstructive pulmonary disease (COPD) and lung cancer are leading cause of death, and both are associated with cigarette smoke exposure. It has been shown that 50–70% of patients diagnosed with lung cancer suffer from COPD, and reduced lung ...
Abdel-Aziz, Adenuga, Barnes, Bonomi, Brock, Campisi, Cao, Chen, Edirisinghe, Fong, Gebel, Goswami, Gozuacik, Gridelli, Hogg, Hogg, Hongwei Yao, Houghton, Irfan Rahman, Ito, Kamlah, Kasahara, Lee, Liu, Liu, Mannino, Marwick, Michaud, Moghaddam, Morris, Nozik-Grayck, Parimon, Pilette, Rajendrasozhan, Reiman, Rossi, Saitoh, Scherz-Shouval, Senderowicz, Siafakas, Sun, Takizawa, Tomita, Tsuji, van der Strate, van Houwelingen, Voelkel, Yamamoto, Yang, Yang, Yao, Yue   +51 more
core   +1 more source