On Top of the Alveolar Epithelium: Surfactant and the Glycocalyx [PDF]
, 2020 Gas exchange in the lung takes place via the air-blood barrier in the septal walls of alveoli. The tissue elements that oxygen molecules have to cross are the alveolar epithelium, the interstitium and the capillary endothelium.
Hegermann, Jan +8 more
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Human decidua-derived mesenchymal stem cells differentiate into functional alveolar type II-like cells that synthesize and secrete pulmonary surfactant complexes. [PDF]
PLoS ONE, 2014 Lung alveolar type II (ATII) cells are specialized in the synthesis and secretion of pulmonary surfactant, a lipid-protein complex that reduces surface tension to minimize the work of breathing.
Alejandro Cerrada +5 more
doaj +1 more source
Immunologic Identification of a Pulmonary Surfactant-Associated Protein of Molecular Weight = 6000 Daltons [PDF]
Pediatric Research, 1986 Hydrophobic, small molecular weight, surfactant-associated protein of Mr = 6000 (SAP-6) was isolated from bovine, canine, and human alveolar lavage and identified by silver staining after sodium dodecyl sulfate polyacrylamide gel electrophoresis gels.
J A, Whitsett +4 more
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Dimerization of the pulmonary surfactant protein C in a membrane environment.
PLoS ONE, 2022 Surfactant protein C (SP-C) has several functions in pulmonary surfactant. These include the transfer of lipids between different membrane structures, a role in surfactant recycling and homeostasis, and involvement in modulation of the innate defense ...
Hanna Korolainen +5 more
doaj +1 more source
Effects of Pulmonary Oxygen Injury on Airway Content of Surfactant-Associated Protein A [PDF]
Pediatric Research, 1988 The use of therapeutic hyperoxia has greatly improved the survival of infants born prematurely. However, high concentrations of oxygen cause pulmonary injury, leading to decreased pulmonary compliance and decreased oxygen diffusion. This injury can result in chronic pulmonary insufficiency. It has been hypothesized that the adverse effects of hyperoxia
L M, Nogee, J R, Wispe
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Cellular & Molecular Biology Letters, 2023 Background The pulmonary surfactant that lines the air–liquid surface within alveoli is a protein–lipid mixture essential for gas exchange. Surfactant lipids and proteins are synthesized and stored in the lamellar body (LB) before being secreted from ...
Wenqin Xu +6 more
doaj +1 more source
Comparison of lipid aggregation and self-aggregation activities of pulmonary surfactant-associated protein A [PDF]
Biochemical Journal, 1996 1. We compared the Ca2+ dependence of the self-aggregation of surfactant protein A (SP-A) with that of vesicle aggregation induced by SP-A. The Ca2+ concentration required for half-maximal activity of lipid aggregation was 0.74±0.29 μM (n = 4) for pig SP-A and 98±5 μM (n = 2) for dog SP-A.
M L, Ruano +3 more
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Budesonide/formoterol enhances the expression of pro Surfactant Protein-B in lungs of COPD patients. [PDF]
PLoS ONE, 2013 Pulmonary surfactants are essential components of lung homeostasis. In chronic obstructive pulmonary disease (COPD), surfactant expression decreases in lungs whereas, there is a paradoxical increase in protein expression in plasma.
Soo Jung Um +4 more
doaj +1 more source
Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response [PDF]
, 2014 Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue.
Floros, Joanna +7 more
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Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2019 Background: M. pneumoniae and CARDS toxin interact with respiratory epithelium in the presence of surfactant protein A (SP-A). Objective of the study was to estimate the production of proinflammatory cytokines from human lung epithelial cells ...
Hlinkina T. V. +3 more
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