Results 41 to 50 of about 985,929 (323)

S-nitrosylation of surfactant protein-D controls inflammatory function. [PDF]

PLoS Biology, 2008
The pulmonary collectins, surfactant proteins A and D (SP-A and SP-D) have been implicated in the regulation of the innate immune system within the lung. In particular, SP-D appears to have both pro- and anti-inflammatory signaling functions. At present,
Chang-Jiang Guo, Elena N Atochina-Vasserman, Elena Abramova, Joseph P Foley, Aisha Zaman, Erika Crouch, Michael F Beers, Rashmin C Savani, Andrew J Gow   +8 more
doaj   +1 more source

Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA [PDF]

, 2019
Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra-
De Backer, Lynn, De Smedt, Stefaan, Echaide, Mercedes, Guagliardo, Roberta, Merckx, Pieterjan, Pérez-Gil, Jesus, Raemdonck, Koen, Zamborlin, Agata   +7 more
core   +1 more source

Surfactant protein A and surfactant protein D variation in pulmonary disease

Immunobiology, 2007
Surfactant proteins A (SP-A) and D (SP-D) have been implicated in pulmonary innate immunity. The proteins are host defense lectins, belonging to the collectin family which also includes mannan-binding lectin (MBL). SP-A and SP-D are pattern-recognition molecules with the lectin domains binding preferentially to sugars on a broad spectrum of pathogen ...
Sørensen, Grith Lykke, Husby, Steffen, Holmskov, Uffe   +2 more
openaire   +2 more sources

The structure of latherin, a surfactant allergen protein from horse sweat and saliva [PDF]

, 2013
Latherin is a highly surface-active allergen protein found in the sweat and saliva of horses and other equids. Its surfactant activity is intrinsic to the protein in its native form, and is manifest without associated lipids or glycosylation.
Alan Cooper, Brian O. Smith, Lamping N, Malcolm W. Kennedy, Rhona E. McDonald, Steven J. Vance, Vance SJ   +6 more
core   +1 more source

Genetics of the hydrophilic surfactant proteins A and D

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1998
The use of candidate genes has increased the ability to identify genetic factors involved in diseases with complex and multifactorial etiology. The surfactant proteins (SP) A and D are involved in host defense and inflammatory processes of the lung, which are often components of pulmonary disease.
Floros, Joanna, Hoover, Russell R.
openaire   +2 more sources

Surfactant proteins A and D: disease markers

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1998
The abundant and restricted expression of surfactant proteins SP-A and SP-D within the lung makes these collectins specific markers for lung diseases. The measurement of SP-A and SP-D in amniotic fluids and tracheal aspirates reflects lung maturity and the production level of the lung surfactant in infants with respiratory distress syndrome (RDS).
Kuroki, Yoshio, Takahashi, Hiroki, Chiba, Hirofumi, Akino, Toyoaki   +3 more
openaire   +2 more sources

A study of surfactant protein-D serum levels in patients with idiopathic pulmonary fibrosis

Egyptian Journal of Chest Disease and Tuberculosis, 2018
Background Several and most recent studies have shown that idiopathic pulmonary fibrosis (IPF) has a high mortality rate and the therapy used is almost noneffective.
Fawzia E Elashry, Ibrahim S Ibrahim, Hoda M Bahr, Halah M Nagy   +3 more
doaj   +1 more source

Surfactant proteins A and D in pregnancy and parturition

Frontiers in Bioscience, 2011
Surfactant proteins A and D have extra-pulmonary expression at various mucosal sites including the reproductive tract. Reproductive tissues require a fine immune balance, strong enough to keep infection at a bay and at the same time, subtle enough to support an allogeneic fetus throughout the pregnancy. Roles of SP-A and SP-D have been studied in depth
Yadav, AK, Madan, T, Lopez Bernal, A
openaire   +3 more sources

Surfactant protein D dampens lung injury by suppressing NLRP3 inflammasome activation and NF-κB signaling in acute pancreatitis

Shock, 2019
Severe acute pancreatitis (SAP) often causes acute lung injury (ALI) by systemic inflammatory response. Surfactant protein D (SP-D) plays critical roles in host defense and inflammation regulation.
Jia Yu, L. Ni, Xiaoyi Zhang, Jing Zhang, Osama Abdel-Razek, Guirong Wang   +5 more
semanticscholar   +1 more source

The Dual Role of Surfactant Protein-D in Vascular Inflammation and Development of Cardiovascular Disease

Frontiers in Immunology, 2019
Cardiovascular disease (CVD) is responsible for 31% of all global deaths. Atherosclerosis is the major cause of cardiovascular disease and is a chronic inflammatory disorder in the arteries.
Kimmie B. Colmorten, A. B. Nexøe, G. Sørensen   +2 more
semanticscholar   +1 more source