Results 61 to 70 of about 17,566,312 (293)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Biomarkers and bacterial pneumonia risk in patients with treated HIV infection: a case-control study [PDF]

, 2013
Background: Despite advances in HIV treatment, bacterial pneumonia continues to cause considerable morbidity and mortality in patients with HIV infection. Studies of biomarker associations with bacterial pneumonia risk in treated HIV-infected patients do
Brian Angus, Gordin, Fred M., Sarah L Pett, Angus, Brian, Bjerk, Sonja M., Sonja M. Bjerk, Sean Emery, Kunisaki, Ken M, Neuhaus, Jacqueline, Ken M Kunisaki, Jacqueline Neuhaus, Ristola, M., Baker, Jason V., Pett, Sarah L, Jason V Baker, Pett, Sarah L., Sonja M Bjerk, Baker, Jason V, Fred M Gordin, Christoph Stephan, Gordin, Fred M, Bjerk, Sonja M, INSIGHT SMART Study Group, Kunisaki, Ken M., Fred M. Gordin, Stephan, Christoph, Casseb, Jorge Simão do Rosário, Ken M. Kunisaki, Sarah L. Pett, Jason V. Baker, Emery, Sean   +30 more
core   +1 more source

Surfactant proteins A and D in Eustachian tube epithelium [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001
Surfactant protein (SP) A and SP-D are collectins that have roles in host defense. The Eustachian tube (ET) maintains the patency between the upper airways and the middle ear. Dysfunction of local mucosal immunity in ET may predispose infants to recurrent otitis media. We recently described preliminary evidence of the expression of SP-A and SP-D in the
Paananen, R., Sormunen, R., Glumhoff, V., van Eijk, M., Hallman, M.   +4 more
openaire   +3 more sources

SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties

Frontiers in Immunology, 2021
Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which maintain lung homeostasis through their dual roles as anti-infectious and immunomodulatory agents.
Alastair Watson, Alastair Watson, Alastair Watson, Jens Madsen, Howard William Clark, Howard William Clark   +5 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

An insight into the diverse roles of surfactant proteins, SP-A and SP-D in innate and adaptive immunity [PDF]

, 2012
PMCID: PMC3369187Surfactant proteins SP-A and SP-D are hydrophilic, collagen-containing calcium-dependent lectins, which appear to have a range of innate immune functions at pulmonary as well as extrapulmonary sites. These proteins bind to target ligands
Kishore, U, Dodagatta-Marri, E, Annapurna eNayak, Nayak, A, Eswari Dodagatta-Marri, Annapurna Nayak, Eswari eDodagatta-Marri, Anthony George Tsolaki, Uday eKishore, Tsolaki, AG, Uday Kishore   +10 more
core   +1 more source

A Fast and Reliable Method Based on QCM-D Instrumentation for the Screening of Nanoparticle/Blood Protein Interactions

Biosensors, 2023
The interactions that nanoparticles have with blood proteins are crucial for their fate in vivo. Such interactions result in the formation of the protein corona around the nanoparticles, and studying them aids in nanoparticle optimization. Quartz crystal
Mariacristina Gagliardi, Laura Colagiorgio, Marco Cecchini   +2 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Vitamin D Depletion in Pregnancy Decreases Survival Time, Oxygen Saturation, Lung Weight and Body Weight in Preterm Rat Offspring. [PDF]

PLoS ONE, 2016
Animal studies suggest a role of vitamin D in fetal lung development although not studied in preterm animals. We tested the hypothesis that vitamin D depletion aggravates respiratory insufficiency in preterm rat offspring.
Sine Lykkedegn, Grith Lykke Sorensen, Signe Sparre Beck-Nielsen, Bartosz Pilecki, Lars Duelund, Niels Marcussen, Henrik Thybo Christesen   +6 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source