Results 31 to 40 of about 5,605 (194)

Blood collection tubes influence serum ficolin-1 and ficolin-2 levels. [PDF]

Clin Vaccine Immunol, 2014
ABSTRACTThe ficolins are members of a recently discovered family of host innate opsonins that can activate the lectin pathway of complement. The ficolins bind many ligands, although they are typically described as binding acetylated sugars. Ficolin-1 (M-ficolin) and ficolin-2 (L-ficolin) are known to bindStreptococcus pneumoniaeserotypes 19C and 11A ...
Brady AM, Spencer BL, Falsey AR, Nahm MH.   +3 more
europepmc   +4 more sources

Anti-Ficolin-2 and Anti-Ficolin-3 Autoantibody Detection by ELISA [PDF]

, 2021
Ficolins are recognition proteins of the lectin pathway of the complement system and also play an important role in innate immunity and in the maintenance of tissue homeostasis. They deserve special attention in the context of autoimmunity since they are involved in the uptake of dying cells. Because the monitoring of systemic lupus erythematosus (SLE)
Dumestre-Pérard, Chantal, Thielens, Nicole, M.   +1 more
openaire   +3 more sources

The Impact of FCN2 Polymorphisms and Haplotypes on the Ficolin‐2 Serum Levels [PDF]

Scandinavian Journal of Immunology, 2007
AbstractFicolin‐2 (L‐ficolin), derived from the FCN2 gene, is an innate immunity pattern recognition molecule found in human serum in which inter‐individual variation in serum appears to be under genetic control. To validate and extend this finding, we developed a sandwich ELISA for detection of human Ficolin‐2 in serum samples and identified FCN2 ...
Munthe-Fog, L, Hummelshøj, T, Hansen, B E, Koch, C, Madsen, H O, Skjødt, K, Garred, P   +6 more
openaire   +3 more sources

Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2 [PDF]

Human Molecular Genetics, 2005
The ficolin 1, 2 and 3 (derived from the FCN1, 2 and 3 genes, respectively) are homologous soluble pattern recognition molecules of importance for innate immunity, comprising collagen-like and fibrinogen-like domains, binding to sugar groups on different types of microorganisms.
Tina, Hummelshoj, Lea, Munthe-Fog, Hans O, Madsen, Teizo, Fujita, Misao, Matsushita, Peter, Garred   +5 more
openaire   +3 more sources

Structural insights into glycan recognition by plant immune receptors: a comparative perspective with animal innate immune systems. [PDF]

Plant J
SUMMARY Pattern recognition receptors (PRRs) function across diverse eukaryotic organisms as a powerful surveillance system to perceive danger signals and to trigger specific adaptive responses. This complex receptor network constitutes the first layer of perception of the innate immune system of plants and mammals.
Vílchez-Pinto G, Garrido-Arandia M, Molina A, Torres MÁ, Jordá L.   +4 more
europepmc   +2 more sources

Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis. [PDF]

, 2016
Cholesterol crystals (CC) play an essential role in the formation of atherosclerotic plaques. CC activate the classical and the alternative complement pathways, but the role of the lectin pathway is unknown.
Genster, Ninette, Gál, Péter, Pilely, Katrine, Pál, Gábor, Rosbjerg, Anne   +4 more
core   +1 more source

Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis [PDF]

Clinical and Experimental Immunology, 2015
Summary Common variable immunodeficiency (CVID) encompasses a heterogeneous group of antibody deficiencies characterized by susceptibility to recurrent infections and sequelae, including bronchiectasis. We investigated the relevance of the lectin complement pathway in CVID patients by analysing ficolin-2 and ficolin-3 serum levels and ...
M-L, Metzger, I, Michelfelder, S, Goldacker, K, Melkaoui, J, Litzman, D, Guzman, B, Grimbacher, U, Salzer   +7 more
openaire   +2 more sources

Frequency and distribution of FCN2 and FCN3 functional variants among MBL2 genotypes. [PDF]

, 2016
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files.
Arnardottir, Margret, Bjarnadottir, Helga, Ludviksson, Bjorn Runar   +2 more
core   +1 more source

Ficolin-2 Levels and FCN2 Genetic Polymorphisms as a Susceptibility Factor in Schistosomiasis [PDF]

Journal of Infectious Diseases, 2012
Human ficolin-2 (L-ficolins) encoded by the FCN2 gene are pattern-recognition proteins involved in innate immunity and are associated with several infectious diseases.A Nigerian cohort of 168 Schistosoma haematobium-infected individuals and 192 healthy controls were examined for functional single-nucleotide polymorphisms in the promoter region (-986G>A,
Eman Abou, Ouf, Olusola, Ojurongbe, Akeem A, Akindele, Olawumi R, Sina-Agbaje, Hoang, Van Tong, Adegboyega O, Adeyeba, Peter G, Kremsner, Jürgen F J, Kun, Tp, Velavan   +8 more
openaire   +3 more sources

Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults

Scientific Reports, 2020
We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as ...
Anna Sokołowska, Anna S. Świerzko, Gabriela Gajek, Aleksandra Gołos, Mateusz Michalski, Mateusz Nowicki, Agnieszka Szala-Poździej, Anna Wolska-Washer, Olga Brzezińska, Agnieszka Wierzbowska, Krzysztof Jamroziak, Marek L. Kowalski, Steffen Thiel, Misao Matsushita, Jens C. Jensenius, Maciej Cedzyński   +15 more
doaj   +1 more source