Results 21 to 30 of about 5,605 (194)

Human L-ficolin (ficolin-2) and its clinical significance. [PDF]

J Biomed Biotechnol, 2012
Human L-ficolin (P35, ficolin-2) is synthesised in the liver and secreted into the bloodstream where it is one of the major pattern recognition molecules of plasma/serum. Like other ficolins, it consists of a collagen-like tail region linked to a fibrinogen-related globular head; a basic triplet subunit arises via a collagen-like triple helix, and this
Kilpatrick DC, Chalmers JD.
europepmc   +6 more sources

Rapid and efficient purification of ficolin-2 using a disposable CELLine bioreactor. [PDF]

J Immunol Methods, 2015
The human opsonin ficolin-2 (L-ficolin) is an innate pattern-recognizing molecule that binds to acetylated moieties. Upon binding, ficolin-2 activates complement through the lectin pathway, opsonizing the target to promote phagocytic clearance. Ficolin-2 has been found to interact with a growing number of pathogenic bacteria, fungi, and viruses ...
Geno KA, Spencer BL, Nahm MH.
europepmc   +4 more sources

Ficolin-2 Plasma Level Assesses Liver Fibrosis in Non-Alcoholic Fatty Liver Disease. [PDF]

Int J Mol Sci, 2022
Abstract Background & Aims: In the next 20 years, non-alcoholic fatty liver disease (NAFLD) is expected to become the leading cause of liver transplantation. Fibrosis is the most important prognostic factor for liver-related outcomes and mortality, but the need for liver biopsy limits diagnosis. We assessed the performance of plasma ficolin-
Giraudi PJ, Salvoza N, Bonazza D, Saitta C, Lombardo D, Casagranda B, de Manzini N, Pollicino T, Raimondo G, Tiribelli C, Palmisano S, Rosso N.   +11 more
europepmc   +5 more sources

Diagnostic Value of Serum Ficolin-3 and Gal-3 in Sepsis Complicated with Acute Kidney Injury [PDF]

International Journal of General Medicine
Hang Yi,1 Ruiping Ye,2 Jinfeng Wang,3 Lin Gao,4 Weiwei Zhang,4 Chao Liu4 1Department of Intensive Care Medicine, Qianjiang Central Hospital, Qianjiang City, Hubei Province, 433100, People’s Republic of China; 2Department of Intensive Care Medicine, The ...
Yi H, Ye R, Wang J, Gao L, Zhang W, Liu C   +5 more
doaj   +2 more sources

Circulating Ficolin-2 and Ficolin-3 Form Heterocomplexes [PDF]

The Journal of Immunology, 2020
Abstract The complement system constitutes an important part of the innate immune system. The collectins and the ficolins are soluble pattern recognition molecules that contribute to complement activation via the lectin pathway. During previous experiments with ficolin-2 and ficolin-3, we have observed that the molecules may interact. We
Ida Jarlhelt, Katrine Pilely, Jytte Bryde Clausen, Mikkel-Ole Skjoedt, Rafael Bayarri-Olmos, Peter Garred   +5 more
openaire   +3 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Human ficolin‐2 recognition versatility extended: An update on the binding of ficolin‐2 to sulfated/phosphated carbohydrates [PDF]

FEBS Letters, 2014
Ficolin‐2 has been reported to bind to DNA and heparin, but the mechanism involved has not been thoroughly investigated. X‐ray studies of the ficolin‐2 fibrinogen‐like domain in complex with several new ligands now show that sulfate and phosphate groups are prone to bind to the S3 binding site of the protein.
Laffly, Emmanuelle, Lacroix, Monique, Martin, Lydie, Vassal-Stermann, Emilie, Thielens, Nicole, Gaboriaud, Christine   +5 more
openaire   +3 more sources

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Commercially available complement component-depleted sera are unexpectedly codepleted of ficolin-2. [PDF]

Clin Vaccine Immunol, 2014
ABSTRACTThe ficolins are a family of innate pattern recognition molecules that are known to bind acetylated compounds and activate complement through the association of mannose binding lectin (MBL)/ficolin-associated serine proteases (MASPs). Their importance has more recently become appreciated, as they have been shown to play a role in a variety of ...
Brady AM, Geno KA, Dalecki AG, Cheng X, Nahm MH.   +4 more
europepmc   +4 more sources

Association between serum ficolin-1 level and disease progression in primary biliary cholangitis

PLoS ONE, 2020
Pattern recognition molecules (PRMs) in the complement system contribute to homeostasis as mediators of complement activation. The contribution of PRMs to primary biliary cholangitis (PBC) is unknown.
Manabu Hayashi, Kazumichi Abe, Masashi Fujita, Atsushi Takahashi, Hideharu Sekine, Hiromasa Ohira, Aftab A. Ansari   +6 more
doaj   +3 more sources