Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes [PDF]
, 2015 Trauma is a major public health problem worldwide. Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma.
Bronkhorst, M.W.G.A. (Maarten) +2 more
core +2 more sources
Anti-Ficolin-2 Antibody: Could It Be a Predictor of Proliferative Lupus Nephritis in Lupus Patients? [PDF]
QJM: An International Journal of Medicine, 2021 Abstract Background Nephritis is a challenging domain of systemic lupus erythematosus (SLE). There is a growing need for identification of a non-invasive marker for diagnosing and monitoring nephritis.
Kamal, Sylvia Talaat +4 more
openaire +2 more sources
Allelic lineages of the ficolin genes (FCNs) are passed from ancestral to descendant primates.
PLoS ONE, 2011 The ficolins recognize carbohydrates and acetylated compounds on microorganisms and dying host cells and are able to activate the lectin pathway of the complement system.
Tina Hummelshøj +5 more
doaj +1 more source
Reactions to synthetic membranes dialyzers: Is there an increase in incidence? [PDF]
, 2019 Background: Reactions to dialyzers used in dialysis have been reported more frequently in recent years. Evidence, however, shows that the reaction rate has remained stable for years.
Carriazo, Sol +8 more
core +2 more sources
Serum opsonin ficolin-A enhances host-fungal interactions and modulates cytokine expression from human monocyte-derived macrophages and neutrophils following Aspergillus fumigatus challenge. [PDF]
, 2015 Invasive aspergillosis is a devastating invasive fungal disease associated with a high mortality rate in the immunocompromised, such as leukaemia patients, transplant patients and those with HIV/AIDS.
Bidula, S, Schelenz, S, Sexton, DW
core +1 more source
Increased expression of ficolin-1 is associated with airway obstruction in asthma
BMC Pulmonary Medicine, 2023 Background The activated complement cascade is involved in asthmatic airway inflammation. Ficolins are essential for innate immunity and can activate the complement lectin pathway.
Pengfei Gao +8 more
doaj +1 more source
Hepatitis C virus relies on lipoproteins for its life cycle [PDF]
, 2016 Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma.
Alonzi, Tonino +5 more
core +1 more source
Autoantibodies Targeting Ficolin‐2 in Systemic Lupus Erythematosus Patients With Active Nephritis [PDF]
Arthritis Care & Research, 2018 ObjectiveSystemic lupus erythematosus (SLE) is a multisystem inflammatory disease characterized by the production of various autoantibodies. The aim of this study was to investigate the presence of anti–ficolin‐2 antibodies in SLE patients and to evaluate the association between the levels of these autoantibodies, clinical manifestations, and disease ...
Colliard, Sophie +11 more
openaire +4 more sources
Frontiers in Immunology, 2020 BackgroundThe role of the lectin pathway of complement in the pathogenesis of interstitial lung diseases (ILDs) is largely unknown. Pattern recognition receptors (PRR) of the lectin pathway are involved in the clearance of apoptotic cells either via ...
Severin Vogt +13 more
doaj +1 more source
The carbohydrate-linked phosphorylcholine of the parasitic nematode product ES-62 modulates complement activation [PDF]
, 2016 Parasitic nematodes manufacture various carbohydratelinked phosphorylcholine (PCh)-containing molecules, including ES-62, a protein with an N-linked glycan terminally substituted with PCh.
Ahmed, Umul Kulthum +5 more
core +1 more source