Results 1 to 10 of about 5,382 (190)

Ficolin-1 and Ficolin-3 Plasma Levels Are Altered in HIV and HIV/HCV Coinfected Patients From Southern Brazil [PDF]

Frontiers in Immunology, 2018
The complement system is a key component of the innate immune system, participating in the surveillance against infectious agents. Once activated by one of the three different pathways, complement mediates cell lysis, opsonization, signalizes pathogens ...
Maria Regina Tizzot, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Hellen Weinschutz Mendes, Marcia Holsbach Beltrame, Edna Reiche, Steffen Thiel, Jens C. Jensenius, Iara J. de Messias-Reason   +8 more
doaj   +8 more sources

Association between serum ficolin-1 level and disease progression in primary biliary cholangitis [PDF]

PLoS ONE, 2020
Pattern recognition molecules (PRMs) in the complement system contribute to homeostasis as mediators of complement activation. The contribution of PRMs to primary biliary cholangitis (PBC) is unknown.
Manabu Hayashi, Kazumichi Abe, Masashi Fujita, Atsushi Takahashi, Hideharu Sekine, Hiromasa Ohira, Aftab A. Ansari   +6 more
doaj   +7 more sources

Increased expression of ficolin-1 is associated with airway obstruction in asthma [PDF]

BMC Pulmonary Medicine, 2023
Background The activated complement cascade is involved in asthmatic airway inflammation. Ficolins are essential for innate immunity and can activate the complement lectin pathway.
Pengfei Gao, Kun Tang, Yanjiao Lu, Meijia Wang, Wei Wang, Tongsheng Wang, Yuxia Sun, Jianping Zhao, Yimin Mao   +8 more
doaj   +4 more sources

Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1 [PDF]

Journal of Translational Medicine
Background Ficolins were originally identified as proteins that bind to transforming growth factor-β1 (TGF-β1). They are capable of activating the complement system through lectin pathway for immune system protection. Ficolin-2 and 3 have been identified
Pengfei Gao, Yanjiao Lu, Kun Tang, Wei Wang, Tongsheng Wang, Yingwei Zhu, Jianping Zhao, Yimin Mao   +7 more
doaj   +4 more sources

Ficolin-1 in pediatric Plasmodium falciparum malaria and its possible role in parasite clearance and anemia [PDF]

Infection and Immunity
Plasmodium falciparum malaria causes significant disease, especially in young children. A successful immune response to P. falciparum is a major determinant of clinical outcome.
Di Zheng, Natalie Ferrington, Dilini Rathnayake, Wina Hasang, Agersew Alemu, Visopo Harawa, Amalia Karahalios, Phoebe Fitzpatrick, Evelyne Gout, Nicole M. Thielens, Karl Seydel, Terrie E. Taylor, Wilson Mandala, Stephen J. Rogerson, Elizabeth H. Aitken, Louise M. Randall   +15 more
doaj   +3 more sources

Sickening or Healing the Heart? The Association of Ficolin-1 and Rheumatic Fever [PDF]

Frontiers in Immunology, 2018
Rheumatic fever (RF) and its subsequent progression to rheumatic heart disease (RHD) are chronic inflammatory disorders prevalent in children and adolescents in underdeveloped countries, and a contributing factor for high morbidity and mortality rates ...
Sandra Jeremias Catarino, Fabiana Antunes Andrade, Angelica Beate Winter Boldt, Angelica Beate Winter Boldt, Luiza Guilherme, Iara Jose Messias-Reason   +5 more
doaj   +5 more sources

Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke. [PDF]

J Neuroinflammation, 2016
Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke.Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding ...
Zangari R, Zanier ER, Torgano G, Bersano A, Beretta S, Beghi E, Casolla B, Checcarelli N, Lanfranconi S, Maino A, Mandelli C, Micieli G, Orzi F, Picetti E, Silvestrini M, Stocchetti N, Zecca B, Garred P, De Simoni MG, LEPAS group.   +19 more
europepmc   +10 more sources

Ficolin-1 is a promising therapeutic target for autoimmune diseases. [PDF]

Int Immunol, 2019
Previously, we reported that mRNA expression of ficolin-1 (FCN1), a component of the complement lectin pathway, is elevated in peripheral blood mononuclear cells of patients with vasculitis syndrome, and that FCN1-positive cells infiltrate into inflamed regions in patient specimens. In addition, we reported that the serum FCN1 concentration is elevated
Katayama M, Ota K, Nagi-Miura N, Ohno N, Yabuta N, Nojima H, Kumanogoh A, Hirano T.   +7 more
europepmc   +3 more sources

Blood collection tubes influence serum ficolin-1 and ficolin-2 levels. [PDF]

Clin Vaccine Immunol, 2014
ABSTRACTThe ficolins are members of a recently discovered family of host innate opsonins that can activate the lectin pathway of complement. The ficolins bind many ligands, although they are typically described as binding acetylated sugars. Ficolin-1 (M-ficolin) and ficolin-2 (L-ficolin) are known to bindStreptococcus pneumoniaeserotypes 19C and 11A ...
Brady AM, Spencer BL, Falsey AR, Nahm MH.   +3 more
europepmc   +4 more sources

Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis

Autoimmunity, 2020
Rheumatoid arthritis (RA) is an autoimmune disease, which compromises the synovial membrane resulting in chronic inflammation. Ficolins are key proteins of the lectin pathway of complement able to recognize pathogen-associated molecular patterns ...
Cristhine Pieczarka, Fabiana Antunes Andrade, Sandra Jeremias Catarino, Kárita Cláudia Freitas Lidani, Lorena Bavia, Regina Tizzot, Thelma Skare, Iara Jose de Messias-Reason   +7 more
doaj   +3 more sources