Results 11 to 20 of about 5,382 (190)

Lectin pathway components and autoantibodies as novel immunological biomarkers in systemic lupus erythematosus (SLE) patients from Western India [PDF]

Scientific Reports
The lectin pathway of complement aids in removing apoptotic cells and maintenance of tissue homeostasis. However, its role in SLE pathogenesis remains unknown.
Kirti Rai, Ridi Khatri, Amrutha Jose, Harshada Konkar, Milind Nadkar, Anjali Rajadhyaksha, Lubka Roumenina, Altaf Parande, Gauthami Bitla, Vijay Padwal, Manisha Madkaikar, Vandana Pradhan   +11 more
doaj   +2 more sources

Enhancement of Ebola Virus Infection via Ficolin-1 Interaction with the Mucin Domain of GP Glycoprotein. [PDF]

J Virol, 2016
ABSTRACT Ebola virus infection requires the surface viral glycoprotein to initiate entry into the target cells. The trimeric glycoprotein is a highly glycosylated viral protein which has been shown to interact with host C-type lectin receptors and the soluble complement recognition protein mannose-binding lectin, thereby enhancing viral ...
Favier AL, Gout E, Reynard O, Ferraris O, Kleman JP, Volchkov V, Peyrefitte C, Thielens NM.   +7 more
europepmc   +6 more sources

Increased levels of ficolin-1 and of C3dg are independently associated with high risk of infection in patients with chronic kidney disease: a prospective cohort study [PDF]

Frontiers in Immunology
Background and hypothesisInfection is a leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). The complement system provides crucial first-line defense against pathogens.
Solbjørg Sagedal, Markus Hovd, Markus Hovd, Anders Åsberg, Anders Åsberg, Tom Eirik Mollnes, Tom Eirik Mollnes, Olav Klingenberg, Olav Klingenberg, Torbjørn Fossum Heldal, Torbjørn Fossum Heldal, Bartlomiej J. Witczak, Trine Korsgaard Hejlesen, Anne Troldborg, Anne Troldborg, Steffen Thiel   +15 more
doaj   +2 more sources

Variation in FCN1 affects biosynthesis of ficolin-1 and is associated with outcome of systemic inflammation [PDF]

Genes and Immunity, 2012
Ficolin-1 is a recognition molecule of the lectin complement pathway. The ficolin-1 gene FCN1 is polymorphic, but the functional and clinical consequences are unknown.The concentration of ficolin-1 in plasma and FCN1 polymorphisms in positions -1981 (rs2989727), -791 (rs28909068), -542 (rs10120023), -271 (rs28909976), -144 (rs10117466) and +7918 ...
Kurtzhals, Ja
exaly   +4 more sources

Complement system activation is associated with spinal radiographic progression in axial spondyloarthritis after 2 years of follow-up: findings from the CONSUL RCT [PDF]

RMD Open
Objective To investigate complement system activation and complement protein levels in relation to radiographic progression in axial spondyloarthritis (axSpA) within a longitudinal randomised controlled trial (RCT) of radiographic axSpA patients ...
Joachim Sieper, Denis Poddubnyy, Joachim Listing, Anne Gitte Loft, Anne Troldborg, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Murat Torgutalp, Steffen Thiel, Burkhard Muche, Clara Mistegaard   +11 more
doaj   +2 more sources

Polymorphism in ficolin-1 (FCN1) gene is associated with an earlier onset of type 1 diabetes mellitus in children and adolescents from northeast Brazil [PDF]

Journal of Genetics, 2016
10siFicolins are innate immune proteins able to activate the complement system by the lectin pathway. Single nucleotide polymorphisms (SNPs) of FCN1 and FCN2 genes, encoding for ficolin 1 and 2, have been related to the susceptibility to infectious and ...
GLAUCIA ALYNE NUNES DE LACERDA, JAQUELINE ARAUJO, JAQUELINE DE AZEVÊDO SILVA, LUCAS ANDRÉ CAVALCANTI BRANDÃO, MANUELLA MARIA SILVA SANTOS, NATASSIA JAVORSKI RODRIGUES, NATHÁLIA DE ALENCAR CUNHA TAVARES, RAFAEL LIMA GUIMARÃES, SERGIO CROVELLA, ZILMA PEREIRA DOS ANJOSA   +9 more
core   +5 more sources

Measurement Concentration of Ficolin-1 and Calprotectin for Serum and Swab in Tonsillitis Infection

Medical Journal of Babylon
Background: Tonsillitis is a common and widespread disease in children. It is related to the immunity of persons, so a group of people with tonsillitis was studied and the immunity associated with tonsillitis was studied by studying some immunological ...
Shaimaa Mohammed Wtwt, Azhar Omran Althahab   +1 more
doaj   +2 more sources

Diagnostic Value of Serum Ficolin-3 and Gal-3 in Sepsis Complicated with Acute Kidney Injury [PDF]

International Journal of General Medicine
Hang Yi,1 Ruiping Ye,2 Jinfeng Wang,3 Lin Gao,4 Weiwei Zhang,4 Chao Liu4 1Department of Intensive Care Medicine, Qianjiang Central Hospital, Qianjiang City, Hubei Province, 433100, People’s Republic of China; 2Department of Intensive Care Medicine, The ...
Yi H, Ye R, Wang J, Gao L, Zhang W, Liu C   +5 more
doaj   +2 more sources

Exploring complement biomarkers in suspected axial spondyloarthritis [PDF]

RMD Open
Objectives To investigate lectin pathway proteins (LPPs) as biomarkers for axial spondyloarthritis (axSpA) in a cross-sectional cohort with a suspicion of axSpA, comprising newly diagnosed axSpA and chronic low back pain (cLBP) individuals.Methods Serum ...
Joachim Sieper, Denis Poddubnyy, Anne Gitte Loft, Anne Troldborg, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Judith Rademacher, Steffen Thiel, Burkhard Muche, Susanne Lüders, Laura Spiller, Anne-Katrin Weber, Clara Elbæk Mistegård   +13 more
doaj   +2 more sources

Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure [PDF]

, 2013
BACKGROUND: Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the lectin
A Krarup, AJ Nauta, Alice Gustavsen, Arne Yndestad, BJ Wrigley, C Honore, C Honore, CA Ogden, CC Wang, Christen P. Dahl, DJ Clark, E Gout, E Hein, Erik T. Askevold, G Fust, George Füst, GH Oliveira, HJ Kim, István Karádi, JJ McMurray, JT Bay, L Munthe-Fog, L Munthe-Fog, L Munthe-Fog, Lars Gullestad, Lea Munthe-Fog, Lívia Jánoskuti, M Lund Jensen, Mikkel-Ole Skjoedt, MJ Walport, N Imai, O Zimmermann, P Aukrust, P Garred, P Garred, P Garred, Peter Garred, Pål Aukrust, RA Kaslow, Robert B. Sim, RS Whelan, RX Li, S Kostin, T Gombos, T Hummelshoj, Thor Ueland, Timea Gombos, Tom E. Mollnes, TP Zwaka, Zoltan Pozsonyi, Zoltán Prohászka, Zsolt Förhécz   +51 more
core   +16 more sources