Association of ficolin-3 with severity and outcome of chronic heart failure. [PDF]
PLoS ONE, 2013 BackgroundInflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown.
Zoltán Prohászka +17 more
doaj +8 more sources
Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus. [PDF]
PLoS ONE, 2016 Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of multiple autoantibodies. Antibodies against Ficolin-3 were previously identified in the sera of some SLE patients, but their prevalence and significance
Maëlle Plawecki +14 more
doaj +7 more sources
Functional analysis of Ficolin-3 mediated complement activation.
PLoS ONE, 2010 The recognition molecules of the lectin complement pathway are mannose-binding lectin and Ficolin -1, -2 and -3. Recently deficiency of Ficolin-3 was found to be associated with life threatening infections.
Estrid Hein +5 more
doaj +6 more sources
Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis
Autoimmunity, 2020 Rheumatoid arthritis (RA) is an autoimmune disease, which compromises the synovial membrane resulting in chronic inflammation. Ficolins are key proteins of the lectin pathway of complement able to recognize pathogen-associated molecular patterns ...
Cristhine Pieczarka +7 more
doaj +3 more sources
The interaction pattern of murine serum ficolin-A with microorganisms. [PDF]
PLoS ONE, 2012 The ficolins are soluble pattern recognition molecules in the lectin pathway of complement, but the spectrum and mode of interaction with pathogens are largely unknown.
Tina Hummelshøj +9 more
doaj +4 more sources
Ficolin-2 and ficolin-3 in women with malignant and benign ovarian tumours [PDF]
Cancer Immunology, Immunotherapy, 2013 Ficolins are serum pattern recognition molecules. They have opsonic properties and are able to activate complement via the lectin pathway. This paper reports investigations concerning ficolin-2 and ficolin-3 in ovarian cancer (OC). Their serum levels, single nucleotide polymorphisms of the corresponding FCN2 and FCN3 genes and specific mRNA expression ...
Agnieszka Szala +2 more
exaly +3 more sources
Association of a new FCN3 haplotype with high ficolin-3 levels in leprosy. [PDF]
PLoS Neglected Tropical Diseases, 2017 Leprosy is a chronic inflammatory disease caused by Mycobacterium leprae that mainly affects the skin and peripheral nervous system, leading to a high disability rate and social stigma.
Fabiana Antunes Andrade +5 more
doaj +4 more sources
Evaluation of Ficolin-3 deficiency as a risk factor in the development of rheumatic heart disease
BMC Research NotesObjective Ficolin-3 is a crucial protein for the activation of the complement system. Previous work has indicated this protein may play a role in the pathogenesis of rheumatic heart disease (RHD), and it has been hypothesised that ficolin-3 has potential
Zahra Parker +5 more
doaj +3 more sources
Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke [PDF]
Iranian Journal of Allergy, Asthma and Immunology, 2017 Stroke is one of the most leading causes of death and disability in the world. Complement system activation contributes to pathogenesis and neuronal damage following stroke.
Ebrahim Kouchaki +3 more
doaj +2 more sources
Mannose-binding lectin deficiency is associated with myocardial infarction: the HUNT2 study in Norway. [PDF]
PLoS ONE, 2012 OBJECTIVES: Mannose-binding lectin (MBL) and ficolins activate the complement cascade, which is involved in atherogenesis. Based on a pilot study, we hypothesized that functional polymorphisms in the MBL gene (MBL2) leading to dysfunctional protein are ...
Inga Thorsen Vengen +5 more
doaj +5 more sources