Results 11 to 20 of about 5,472 (201)

Changes of Serum Ficolin-3 and C5b-9 in Patients with Heart Failure [PDF]

Pakistan Journal of Medical Sciences, 2021
Objectives: To investigate the correlation of serum ficolin-3 and C5b-9 with cardiac function and NT-proBNP in patients with heart failure. Methods: Sixty patients with heart failure admitted to the Baoding First Central Hospital from May 2019 to May 2020 were selected and divided into three groups according to the classification of New York ...
Li, Hongli, Zhang, Fangfang, Zhang, Dan, Tian, Xiang   +3 more
openaire   +4 more sources

The clinical value of ficolin-3 gene polymorphism in rheumatic heart disease. An Egyptian adolescents study [PDF]

BMC Research Notes, 2021
Objective Ficolin-3 is one of the innate immunity molecules that was thought to play a pivotal role in Streptococcus pyogenes autoimmunity and its complications; rheumatic fever (RF) and rheumatic heart disease (RHD).
Maher H. Gomaa, Emad Gamil Khidr, Ahmed Elshafei, Hala S. Hamza, Aya M. Fattouh, Ahmed A. El-Husseiny, Ahmed Aglan, Mahmoud Gomaa Eldeib   +7 more
doaj   +2 more sources

Loss of ficolin-3 expression is associated with poor prognosis in patients with hepatocellular carcinoma [PDF]

International Journal of Medical Sciences, 2023
Background: Ficolin-3 (FCN3) is a well-known circulating pattern recognition molecule which plays a role in host immune responses to cancer via activation of the lectin complement pathway. Nevertheless, the clinical significance of FCN3 in patients with hepatocellular carcinoma (HCC) is unclear.
Chen, Chia-Chi, Yu, Teng-Hung, Wu, Cheng-Ching, Hung, Wei-Chin, Lee, Thung-Lip, Tang, Wei-Hua, Tsai, I-Ting, Chung, Fu-Mei, Lee, Yau-Jiunn, Hsu, Chia-Chang   +9 more
openaire   +3 more sources

Ficolin-1 and Ficolin-3 Plasma Levels Are Altered in HIV and HIV/HCV Coinfected Patients From Southern Brazil [PDF]

Frontiers in Immunology, 2018
The complement system is a key component of the innate immune system, participating in the surveillance against infectious agents. Once activated by one of the three different pathways, complement mediates cell lysis, opsonization, signalizes pathogens ...
Maria Regina Tizzot, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Hellen Weinschutz Mendes, Marcia Holsbach Beltrame, Edna Reiche, Steffen Thiel, Jens C. Jensenius, Iara J. de Messias-Reason   +8 more
doaj   +2 more sources

A New Ligand-Based Method for Purifying Active Human Plasma-Derived Ficolin-3 Complexes Supports the Phenomenon of Crosstalk between Pattern-Recognition Molecules and Immunoglobulins. [PDF]

PLoS ONE, 2016
Despite recombinant protein technology development, proteins isolated from natural sources remain important for structure and activity determination. Ficolins represent a class of proteins that are difficult to isolate.
Aleksandra Man-Kupisinska, Mateusz Michalski, Anna Maciejewska, Anna S Swierzko, Maciej Cedzynski, Czeslaw Lugowski, Jolanta Lukasiewicz   +6 more
doaj   +2 more sources

Ficolin‐3/adiponectin ratio for the prediction of gestational diabetes mellitus in pregnant women [PDF]

Journal of Diabetes Investigation, 2017
AbstractAims/IntroductionTo establish that the ficolin‐3/adiponectin ratio is a predictor for gestational diabetes mellitus (GDM) and is eligible for screening tests for GDM.Materials and MethodsA prospective cohort study of 86 pregnant women who developed GDM and 273 normal glucose tolerance participants was carried out.
Xiao‐song Yuan, Hui Shi, Hui‐yan Wang, Bin Yu, Jian Jiang   +4 more
openaire   +3 more sources

Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus [PDF]

Frontiers in Immunology, 2019
Bacterial infections are frequent and severe in patients with diabetes mellitus. Whether diabetes per se induces functional alterations in the complement system hampering activation during infection is unknown.
László József Barkai, Emese Sipter, Dorottya Csuka, Zoltán Prohászka, Katrine Pilely, Peter Garred, Nóra Hosszúfalusi   +6 more
doaj   +2 more sources

Structural insights into glycan recognition by plant immune receptors: a comparative perspective with animal innate immune systems. [PDF]

Plant J
SUMMARY Pattern recognition receptors (PRRs) function across diverse eukaryotic organisms as a powerful surveillance system to perceive danger signals and to trigger specific adaptive responses. This complex receptor network constitutes the first layer of perception of the innate immune system of plants and mammals.
Vílchez-Pinto G, Garrido-Arandia M, Molina A, Torres MÁ, Jordá L.   +4 more
europepmc   +2 more sources

Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis [PDF]

Journal of Experimental & Clinical Cancer Research
Background Targeting ferroptosis has been identified as a promising approach for the development of cancer therapies. Monounsaturated fatty acid (MUFA) is a type of lipid that plays a crucial role in inhibiting ferroptosis.
Yanmei Yuan, Junting Xu, Quanxin Jiang, Chuanxin Yang, Ning Wang, Xiaolong Liu, Hai-long Piao, Sijia Lu, Xianjing Zhang, Liu Han, Zhiyan Liu, Jiabin Cai, Fang Liu, Suzhen Chen, Junli Liu   +14 more
doaj   +2 more sources

Lectin pathway components and autoantibodies as novel immunological biomarkers in systemic lupus erythematosus (SLE) patients from Western India [PDF]

Scientific Reports
The lectin pathway of complement aids in removing apoptotic cells and maintenance of tissue homeostasis. However, its role in SLE pathogenesis remains unknown.
Kirti Rai, Ridi Khatri, Amrutha Jose, Harshada Konkar, Milind Nadkar, Anjali Rajadhyaksha, Lubka Roumenina, Altaf Parande, Gauthami Bitla, Vijay Padwal, Manisha Madkaikar, Vandana Pradhan   +11 more
doaj   +2 more sources