Results 31 to 40 of about 5,472 (201)

Allelic lineages of the ficolin genes (FCNs) are passed from ancestral to descendant primates.

PLoS ONE, 2011
The ficolins recognize carbohydrates and acetylated compounds on microorganisms and dying host cells and are able to activate the lectin pathway of the complement system.
Tina Hummelshøj, Janna Nissen, Lea Munthe-Fog, Claus Koch, Mads Frost Bertelsen, Peter Garred   +5 more
doaj   +1 more source

Lectin complement pathway initiators after subarachnoid hemorrhage — an observational study

Journal of Neuroinflammation, 2020
Background This exploratory study investigated the time-course of lectin complement pathway (LCP) initiators in cerebrospinal fluid (CSF) and plasma in patients with subarachnoid hemorrhage (SAH), as well as their relationship to delayed cerebral ...
Jeppe Sillesen Matzen, Charlotte Loumann Krogh, Julie Lyng Forman, Peter Garred, Kirsten Møller, Søren Bache   +5 more
doaj   +1 more source

Increased expression of ficolin-1 is associated with airway obstruction in asthma

BMC Pulmonary Medicine, 2023
Background The activated complement cascade is involved in asthmatic airway inflammation. Ficolins are essential for innate immunity and can activate the complement lectin pathway.
Pengfei Gao, Kun Tang, Yanjiao Lu, Meijia Wang, Wei Wang, Tongsheng Wang, Yuxia Sun, Jianping Zhao, Yimin Mao   +8 more
doaj   +1 more source

Frequency and distribution of FCN2 and FCN3 functional variants among MBL2 genotypes. [PDF]

, 2016
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files.
Arnardottir, Margret, Bjarnadottir, Helga, Ludviksson, Bjorn Runar   +2 more
core   +1 more source

Interactions of ficolin-3 with ovarian cancer cells

Immunobiology, 2019
Ficolin-3 is a pattern-recognition molecule with the ability to activate the lectin pathway of complement. It is found in lung, liver and blood, but its physiological role is unclear. We have investigated interaction of recombinant ficolin-3 with malignant cells and tissues.Cells of various lines of human origin as well as ovarian tissue sections have ...
Mateusz, Michalski, Anna S, Świerzko, Sambor, Sawicki, Andrzej, Kałużyński, Jolanta, Łukasiewicz, Anna, Maciejewska, Dariusz, Wydra, Maciej, Cedzyński   +7 more
openaire   +2 more sources

A new case of congenital ficolin-3 deficiency with primary immunodeficiency

Expert Review of Clinical Immunology, 2020
Human Ficolin-3 (FCN3) is an oligomeric-structured lectin encoded by the FCN3 gene with a pivotal role in the lectin complement pathway. It has anti-microbial activities against bacterial and viral infections and restrains opportunistic pathogens. Mutation in the FCN3 gene is associated with variable clinical manifestations particularly immunologic ...
Fateme Babaha, Hassan Abolhassani, Zahra Hamidi Esfahani, Reza Yazdani, Asghar Aghamohammadi   +4 more
openaire   +2 more sources

Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke

Journal of Neuroinflammation, 2011
Background A number of data indicate that the lectin pathway of complement activation contributes to the pathophysiology of ischemic stroke. The lectin pathway may be triggered by the binding of mannose-binding lectin (MBL), ficolin-2 or ficolin-3 to ...
Füst George, Munthe-Fog Lea, Illes Zsolt, Széplaki Gábor, Molnar Tihamér, Pusch Gabriella, Hirschberg Kristóf, Szegedi Robert, Széplaki Zoltán, Prohászka Zoltán, Skjoedt Mikkel-Ole, Garred Peter   +11 more
doaj   +1 more source

Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults

Scientific Reports, 2020
We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as ...
Anna Sokołowska, Anna S. Świerzko, Gabriela Gajek, Aleksandra Gołos, Mateusz Michalski, Mateusz Nowicki, Agnieszka Szala-Poździej, Anna Wolska-Washer, Olga Brzezińska, Agnieszka Wierzbowska, Krzysztof Jamroziak, Marek L. Kowalski, Steffen Thiel, Misao Matsushita, Jens C. Jensenius, Maciej Cedzyński   +15 more
doaj   +1 more source

Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis. [PDF]

, 2016
Cholesterol crystals (CC) play an essential role in the formation of atherosclerotic plaques. CC activate the classical and the alternative complement pathways, but the role of the lectin pathway is unknown.
Genster, Ninette, Gál, Péter, Pilely, Katrine, Pál, Gábor, Rosbjerg, Anne   +4 more
core   +1 more source

New functional ligands for ficolin-3 among lipopolysaccharides of Hafnia alvei [PDF]

Glycobiology, 2011
Ficolin-1 (M), ficolin-2 (L), ficolin-3 (H) and mannan-binding lectin (MBL) activate the complement system and have opsonic activity. The specificity of ficolin-3 is poorly characterized and currently limited to a few ligands only. We present new specific targets for human ficolin-3, identified among lipopolysaccharides (LPSs, endotoxin) of Hafnia ...
Anna, Swierzko, Jolanta, Lukasiewicz, Maciej, Cedzynski, Anna, Maciejewska, Wojciech, Jachymek, Tomasz, Niedziela, Misao, Matsushita, Czeslaw, Lugowski   +7 more
openaire   +2 more sources