Results 21 to 30 of about 5,472 (201)

Genetic Susceptibility to Rheumatic Heart Disease: A Narrative Literature Review Highlighting Evidence From African Populations and Research Gaps in Sudan. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Rheumatic heart disease (RHD) remains a significant public health burden in low‐ and middle‐income countries, particularly in sub‐Saharan Africa. Although socioeconomic factors contribute to disease persistence, genetic susceptibility plays a critical role in determining progression from Group A Streptococcal infection to ...
Alkhalifamohamed H, Jebreel WMA, Elhassan M, Ali SKM.   +3 more
europepmc   +2 more sources

Diagnostic Value of Serum Ficolin-3 and Gal-3 in Sepsis Complicated with Acute Kidney Injury [PDF]

International Journal of General Medicine
Hang Yi,1 Ruiping Ye,2 Jinfeng Wang,3 Lin Gao,4 Weiwei Zhang,4 Chao Liu4 1Department of Intensive Care Medicine, Qianjiang Central Hospital, Qianjiang City, Hubei Province, 433100, People’s Republic of China; 2Department of Intensive Care Medicine, The ...
Yi H, Ye R, Wang J, Gao L, Zhang W, Liu C   +5 more
doaj   +2 more sources

Complement system activation is associated with spinal radiographic progression in axial spondyloarthritis after 2 years of follow-up: findings from the CONSUL RCT [PDF]

RMD Open
Objective To investigate complement system activation and complement protein levels in relation to radiographic progression in axial spondyloarthritis (axSpA) within a longitudinal randomised controlled trial (RCT) of radiographic axSpA patients ...
Joachim Sieper, Denis Poddubnyy, Joachim Listing, Anne Gitte Loft, Anne Troldborg, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Murat Torgutalp, Steffen Thiel, Burkhard Muche, Clara Mistegaard   +11 more
doaj   +2 more sources

Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1 [PDF]

Journal of Translational Medicine
Background Ficolins were originally identified as proteins that bind to transforming growth factor-β1 (TGF-β1). They are capable of activating the complement system through lectin pathway for immune system protection. Ficolin-2 and 3 have been identified
Pengfei Gao, Yanjiao Lu, Kun Tang, Wei Wang, Tongsheng Wang, Yingwei Zhu, Jianping Zhao, Yimin Mao   +7 more
doaj   +2 more sources

Circulating Ficolin-2 and Ficolin-3 Form Heterocomplexes [PDF]

The Journal of Immunology, 2020
Abstract The complement system constitutes an important part of the innate immune system. The collectins and the ficolins are soluble pattern recognition molecules that contribute to complement activation via the lectin pathway. During previous experiments with ficolin-2 and ficolin-3, we have observed that the molecules may interact. We
Ida Jarlhelt, Katrine Pilely, Jytte Bryde Clausen, Mikkel-Ole Skjoedt, Rafael Bayarri-Olmos, Peter Garred   +5 more
openaire   +3 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Association between serum ficolin-1 level and disease progression in primary biliary cholangitis

PLoS ONE, 2020
Pattern recognition molecules (PRMs) in the complement system contribute to homeostasis as mediators of complement activation. The contribution of PRMs to primary biliary cholangitis (PBC) is unknown.
Manabu Hayashi, Kazumichi Abe, Masashi Fujita, Atsushi Takahashi, Hideharu Sekine, Hiromasa Ohira, Aftab A. Ansari   +6 more
doaj   +3 more sources

Association of ficolin‐3 with abdominal aortic aneurysm presence and progression [PDF]

Journal of Thrombosis and Haemostasis, 2017
Essentials Abdominal aortic aneurysm (AAA) is asymptomatic and its evolution unpredictable. To find novel potential biomarkers of AAA, microvesicles are an excellent source of biomarkers. Ficolin-3 is increased in microvesicles obtained from activated platelets and AAA tissue.
Fernandez-García, C-E, Burillo, E, Lindholt, J S, Martinez-Lopez, D, Pilely, K, Mazzeo, C, Michel, J-B, Egido, J, Garred, P, Blanco-Colio, L M, Martin-Ventura, J L   +10 more
openaire   +3 more sources

Anti-Ficolin-2 and Anti-Ficolin-3 Autoantibody Detection by ELISA [PDF]

, 2021
Ficolins are recognition proteins of the lectin pathway of the complement system and also play an important role in innate immunity and in the maintenance of tissue homeostasis. They deserve special attention in the context of autoimmunity since they are involved in the uptake of dying cells. Because the monitoring of systemic lupus erythematosus (SLE)
Dumestre-Pérard, Chantal, Thielens, Nicole, M.   +1 more
openaire   +3 more sources