Results 11 to 20 of about 4,930 (172)
Exploring complement biomarkers in suspected axial spondyloarthritis [PDF]
RMD OpenObjectives To investigate lectin pathway proteins (LPPs) as biomarkers for axial spondyloarthritis (axSpA) in a cross-sectional cohort with a suspicion of axSpA, comprising newly diagnosed axSpA and chronic low back pain (cLBP) individuals.Methods Serum ...
Joachim Sieper +13 more
doaj +2 more sources
Circulating Ficolin-2 and Ficolin-3 Form Heterocomplexes [PDF]
The Journal of Immunology, 2020 Abstract The complement system constitutes an important part of the innate immune system. The collectins and the ficolins are soluble pattern recognition molecules that contribute to complement activation via the lectin pathway. During previous experiments with ficolin-2 and ficolin-3, we have observed that the molecules may interact. We
Ida Jarlhelt +5 more
openaire +3 more sources
Journal of Innate Immunity, 2010 Udgivelsesdato: 2009 ...
Garred, Peter, Borregaard, Niels
openaire +3 more sources
Ficolin-2 inhibitors are present in sera after prolonged storage at −80 °C [PDF]
PeerJ, 2016 Ficolins can activate the lectin pathway of the complement system that provides innate immune protection against pathogens, marks host cellular debris for clearance, and promotes inflammation.
Kimball Aaron Geno +4 more
doaj +2 more sources
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
The Genetics of Ficolins [PDF]
Journal of Innate Immunity, 2009 Ficolins constitute a family of proteins whose biological role has been an enigma for many years. Over the past few years it has become evident that ficolins are part of the innate immune system and function as recognition molecules in the complement system.
Garred, Peter +6 more
openaire +3 more sources
Association between serum ficolin-1 level and disease progression in primary biliary cholangitis
PLoS ONE, 2020 Pattern recognition molecules (PRMs) in the complement system contribute to homeostasis as mediators of complement activation. The contribution of PRMs to primary biliary cholangitis (PBC) is unknown.
Manabu Hayashi +6 more
doaj +3 more sources
Human L-Ficolin (Ficolin-2) and Its Clinical Significance [PDF]
Journal of Biomedicine and Biotechnology, 2012 Human L-ficolin (P35, ficolin-2) is synthesised in the liver and secreted into the bloodstream where it is one of the major pattern recognition molecules of plasma/serum. Like other ficolins, it consists of a collagen-like tail region linked to a fibrinogen-related globular head; a basic triplet subunit arises via a collagen-like triple helix, and this
Kilpatrick, David C., Chalmers, James D.
openaire +4 more sources
Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus. [PDF]
PLoS ONE, 2016 Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of multiple autoantibodies. Antibodies against Ficolin-3 were previously identified in the sera of some SLE patients, but their prevalence and significance
Maëlle Plawecki +14 more
doaj +1 more source