Results 11 to 20 of about 7,922 (214)

Exploring complement biomarkers in suspected axial spondyloarthritis [PDF]

RMD Open
Objectives To investigate lectin pathway proteins (LPPs) as biomarkers for axial spondyloarthritis (axSpA) in a cross-sectional cohort with a suspicion of axSpA, comprising newly diagnosed axSpA and chronic low back pain (cLBP) individuals.Methods Serum ...
Joachim Sieper, Denis Poddubnyy, Anne Gitte Loft, Anne Troldborg, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Judith Rademacher, Steffen Thiel, Burkhard Muche, Susanne Lüders, Laura Spiller, Anne-Katrin Weber, Clara Elbæk Mistegård   +13 more
doaj   +2 more sources

Structural insights into glycan recognition by plant immune receptors: a comparative perspective with animal innate immune systems. [PDF]

Plant J
SUMMARY Pattern recognition receptors (PRRs) function across diverse eukaryotic organisms as a powerful surveillance system to perceive danger signals and to trigger specific adaptive responses. This complex receptor network constitutes the first layer of perception of the innate immune system of plants and mammals.
Vílchez-Pinto G, Garrido-Arandia M, Molina A, Torres MÁ, Jordá L.   +4 more
europepmc   +2 more sources

Circulating Ficolin-2 and Ficolin-3 Form Heterocomplexes [PDF]

The Journal of Immunology, 2020
Abstract The complement system constitutes an important part of the innate immune system. The collectins and the ficolins are soluble pattern recognition molecules that contribute to complement activation via the lectin pathway. During previous experiments with ficolin-2 and ficolin-3, we have observed that the molecules may interact. We
Ida Jarlhelt, Katrine Pilely, Jytte Bryde Clausen, Mikkel-Ole Skjoedt, Rafael Bayarri-Olmos, Peter Garred   +5 more
openaire   +3 more sources

The Ficolins [PDF]

Journal of Innate Immunity, 2010
Udgivelsesdato: 2009 ...
Garred, Peter, Borregaard, Niels
openaire   +3 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

The Genetics of Ficolins [PDF]

Journal of Innate Immunity, 2009
Ficolins constitute a family of proteins whose biological role has been an enigma for many years. Over the past few years it has become evident that ficolins are part of the innate immune system and function as recognition molecules in the complement system.
Garred, Peter, Honoré, Christian, Ma, Ying Jie, Rørvig, Sara, Cowland, Jack, Borregaard, Niels, Hummelshøj, Tina   +6 more
openaire   +4 more sources

Ficolin-2 inhibitors are present in sera after prolonged storage at −80 °C [PDF]

PeerJ, 2016
Ficolins can activate the lectin pathway of the complement system that provides innate immune protection against pathogens, marks host cellular debris for clearance, and promotes inflammation.
Kimball Aaron Geno, Richard E. Kennedy, Patricia Sawyer, Cynthia J. Brown, Moon H. Nahm   +4 more
doaj   +2 more sources

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Association between serum ficolin-1 level and disease progression in primary biliary cholangitis

PLoS ONE, 2020
Pattern recognition molecules (PRMs) in the complement system contribute to homeostasis as mediators of complement activation. The contribution of PRMs to primary biliary cholangitis (PBC) is unknown.
Manabu Hayashi, Kazumichi Abe, Masashi Fujita, Atsushi Takahashi, Hideharu Sekine, Hiromasa Ohira, Aftab A. Ansari   +6 more
doaj   +3 more sources

Genetic Susceptibility to Rheumatic Heart Disease: A Narrative Literature Review Highlighting Evidence From African Populations and Research Gaps in Sudan. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Rheumatic heart disease (RHD) remains a significant public health burden in low‐ and middle‐income countries, particularly in sub‐Saharan Africa. Although socioeconomic factors contribute to disease persistence, genetic susceptibility plays a critical role in determining progression from Group A Streptococcal infection to ...
Alkhalifamohamed H, Jebreel WMA, Elhassan M, Ali SKM.   +3 more
europepmc   +2 more sources