Results 21 to 30 of about 4,930 (172)

Anti-Ficolin-2 and Anti-Ficolin-3 Autoantibody Detection by ELISA [PDF]

, 2021
Ficolins are recognition proteins of the lectin pathway of the complement system and also play an important role in innate immunity and in the maintenance of tissue homeostasis. They deserve special attention in the context of autoimmunity since they are involved in the uptake of dying cells. Because the monitoring of systemic lupus erythematosus (SLE)
Dumestre-Pérard, Chantal, Thielens, Nicole, M.   +1 more
openaire   +3 more sources

Increased expression of ficolin-1 is associated with airway obstruction in asthma

BMC Pulmonary Medicine, 2023
Background The activated complement cascade is involved in asthmatic airway inflammation. Ficolins are essential for innate immunity and can activate the complement lectin pathway.
Pengfei Gao, Kun Tang, Yanjiao Lu, Meijia Wang, Wei Wang, Tongsheng Wang, Yuxia Sun, Jianping Zhao, Yimin Mao   +8 more
doaj   +1 more source

Allelic lineages of the ficolin genes (FCNs) are passed from ancestral to descendant primates.

PLoS ONE, 2011
The ficolins recognize carbohydrates and acetylated compounds on microorganisms and dying host cells and are able to activate the lectin pathway of the complement system.
Tina Hummelshøj, Janna Nissen, Lea Munthe-Fog, Claus Koch, Mads Frost Bertelsen, Peter Garred   +5 more
doaj   +1 more source

Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis

Autoimmunity, 2020
Rheumatoid arthritis (RA) is an autoimmune disease, which compromises the synovial membrane resulting in chronic inflammation. Ficolins are key proteins of the lectin pathway of complement able to recognize pathogen-associated molecular patterns, apoptotic cells, and cellular debris mediating the clearance by phagocytes.
Cristhine Pieczarka, Fabiana Antunes Andrade, Sandra Jeremias Catarino, Kárita Cláudia Freitas Lidani, Lorena Bavia, Regina Tizzot, Thelma Skare, Iara Jose de Messias-Reason   +7 more
openaire   +3 more sources

Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans.

PLoS ONE, 2013
Human ficolin-2 (ficolin-2/P35) is a lectin complement pathway activator that is present in normal human plasma and is associated with infectious diseases; however, little is known regarding the roles and mechanisms of ficolin-2 during Mycobacterium ...
Fengling Luo, Xiaoming Sun, Yubin Wang, Qilong Wang, Yanhong Wu, Qin Pan, Chao Fang, Xiao-Lian Zhang   +7 more
doaj   +1 more source

The interaction pattern of murine serum ficolin-A with microorganisms.

PLoS ONE, 2012
The ficolins are soluble pattern recognition molecules in the lectin pathway of complement, but the spectrum and mode of interaction with pathogens are largely unknown.
Tina Hummelshøj, Ying Jie Ma, Lea Munthe-Fog, Thomas Bjarnsholt, Claus Moser, Mikkel-Ole Skjoedt, Luigina Romani, Teizo Fujita, Yuichi Endo, Peter Garred   +9 more
doaj   +1 more source

Association of FCN2 polymorphisms and Ficolin-2 levels with dengue fever in Vietnamese patients

International Journal of Infectious Diseases, 2020
Background and objective: The human ficolin-2, encoded by FCN2, recognizes pathogen-associated acetylated residues on their cell surfaces and activates the lectin complement cascade. This study aimed to investigate the contribution of human ficolin-2 and
Ngo Truong Giang, Hoang Van Tong, Trinh Huu Nghia, Hoang Vu Hung, Do Tuan Anh, Le Van Nam, Can Van Mao, Nguyen Truong Giang, Le Dinh Thanh, Ho Anh Son, Thirumalaisamy P. Velavan, Quyet Do, Nguyen Linh Toan   +12 more
doaj   +1 more source

Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults

Scientific Reports, 2020
We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as ...
Anna Sokołowska, Anna S. Świerzko, Gabriela Gajek, Aleksandra Gołos, Mateusz Michalski, Mateusz Nowicki, Agnieszka Szala-Poździej, Anna Wolska-Washer, Olga Brzezińska, Agnieszka Wierzbowska, Krzysztof Jamroziak, Marek L. Kowalski, Steffen Thiel, Misao Matsushita, Jens C. Jensenius, Maciej Cedzyński   +15 more
doaj   +1 more source

Lectin complement pathway initiators after subarachnoid hemorrhage — an observational study

Journal of Neuroinflammation, 2020
Background This exploratory study investigated the time-course of lectin complement pathway (LCP) initiators in cerebrospinal fluid (CSF) and plasma in patients with subarachnoid hemorrhage (SAH), as well as their relationship to delayed cerebral ...
Jeppe Sillesen Matzen, Charlotte Loumann Krogh, Julie Lyng Forman, Peter Garred, Kirsten Møller, Søren Bache   +5 more
doaj   +1 more source

Association of low ficolin-2 concentration in cord serum with respiratory distress syndrome in preterm newborns

Frontiers in Immunology, 2023
IntroductionFicolin-2 is a serum pattern recognition molecule, involved in complement activation via the lectin pathway. This study aimed to investigate the association of ficolin-2 concentration in cord blood serum with complications related to ...
Gabriela Gajek, Anna S. Świerzko, Dariusz Jarych, Damian Mikulski, Paulina Kobiela, Karolina Chojnacka, Maja Kufelnicka-Babout, Agnieszka Szala-Poździej, Jędrzej Chrzanowski, Katarzyna Sobczuk, Wojciech Fendler, Misao Matsushita, Iwona Domżalska-Popadiuk, Jan Mazela, Jarosław Kalinka, Hideharu Sekine, Maciej Cedzyński   +16 more
doaj   +1 more source