Results 21 to 30 of about 7,922 (214)

Human L-Ficolin (Ficolin-2) and Its Clinical Significance [PDF]

Journal of Biomedicine and Biotechnology, 2012
Human L-ficolin (P35, ficolin-2) is synthesised in the liver and secreted into the bloodstream where it is one of the major pattern recognition molecules of plasma/serum. Like other ficolins, it consists of a collagen-like tail region linked to a fibrinogen-related globular head; a basic triplet subunit arises via a collagen-like triple helix, and this
Kilpatrick, David C., Chalmers, James D.
openaire   +4 more sources

The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection [PDF]

, 2012
The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Ali, Youssif M., Andrew, Peter W., Dudler, Thomas, Endo, Yuichi, Fujita, Teizo, Girija, Umakhanth V., Haleem, Kashif S., Hansen, Soren, Holmskov, Uffe, Kadioglu, Aras, Lynch, Nicholas J., Schwaeble, Wilhelm J., Stahl, Gregory L., Stover, Cordula M., Takahashi, Kazue, Wallis, Russell   +15 more
core   +6 more sources

Anti-Ficolin-2 and Anti-Ficolin-3 Autoantibody Detection by ELISA [PDF]

, 2021
Ficolins are recognition proteins of the lectin pathway of the complement system and also play an important role in innate immunity and in the maintenance of tissue homeostasis. They deserve special attention in the context of autoimmunity since they are involved in the uptake of dying cells. Because the monitoring of systemic lupus erythematosus (SLE)
Dumestre-Pérard, Chantal, Thielens, Nicole, M.   +1 more
openaire   +3 more sources

Allelic lineages of the ficolin genes (FCNs) are passed from ancestral to descendant primates.

PLoS ONE, 2011
The ficolins recognize carbohydrates and acetylated compounds on microorganisms and dying host cells and are able to activate the lectin pathway of the complement system.
Tina Hummelshøj, Janna Nissen, Lea Munthe-Fog, Claus Koch, Mads Frost Bertelsen, Peter Garred   +5 more
doaj   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H., Mitchell, Daniel A., Schmid, Ralf, Schwaeble, Wilhelm J., Wallis, Russell   +4 more
core   +1 more source

H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses. [PDF]

, 2015
Aspergillus fumigatus is an opportunistic fungal pathogen that typically infects the lungs of immunocompromised patients leading to a high mortality.
Akaiwa, Ali, Azuma, Balloy, Bidula, Bidula, Bidula, D'Haese, De Pauw, DeHart, Foster, Garlatti, Hammond, Hearn, Hummelshøj, Kenawy, Latge, Le, Luo, Ma, Ma, Ma, Madan, Mambula, Martin, Martinez, Matsushita, Matsushita, Matsushita, Meier, Munthe-Fog, Neth, Romani, Rubino, Schelenz, Schelenz, Steele, Steinbach, Sturtevant, Taccone, Thornton, Torok, Werner, Wetering, Zacho, Zhang, Zhao   +46 more
core   +1 more source

Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis

Autoimmunity, 2020
Rheumatoid arthritis (RA) is an autoimmune disease, which compromises the synovial membrane resulting in chronic inflammation. Ficolins are key proteins of the lectin pathway of complement able to recognize pathogen-associated molecular patterns, apoptotic cells, and cellular debris mediating the clearance by phagocytes.
Cristhine Pieczarka, Fabiana Antunes Andrade, Sandra Jeremias Catarino, Kárita Cláudia Freitas Lidani, Lorena Bavia, Regina Tizzot, Thelma Skare, Iara Jose de Messias-Reason   +7 more
openaire   +3 more sources

Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans.

PLoS ONE, 2013
Human ficolin-2 (ficolin-2/P35) is a lectin complement pathway activator that is present in normal human plasma and is associated with infectious diseases; however, little is known regarding the roles and mechanisms of ficolin-2 during Mycobacterium ...
Fengling Luo, Xiaoming Sun, Yubin Wang, Qilong Wang, Yanhong Wu, Qin Pan, Chao Fang, Xiao-Lian Zhang   +7 more
doaj   +1 more source

Sequencing and analysis of the gastrula transcriptome of the brittle star Ophiocoma wendtii [PDF]

, 2012
Background The gastrula stage represents the point in development at which the three primary germ layers diverge. At this point the gene regulatory networks that specify the germ layers are established and the genes that define the differentiated states ...
Garey, James R., Garnhart, Nancy, Livingston, Brian T., Thomas, W. Kelley, Vaughn, Roy   +4 more
core   +2 more sources

The interaction pattern of murine serum ficolin-A with microorganisms.

PLoS ONE, 2012
The ficolins are soluble pattern recognition molecules in the lectin pathway of complement, but the spectrum and mode of interaction with pathogens are largely unknown.
Tina Hummelshøj, Ying Jie Ma, Lea Munthe-Fog, Thomas Bjarnsholt, Claus Moser, Mikkel-Ole Skjoedt, Luigina Romani, Teizo Fujita, Yuichi Endo, Peter Garred   +9 more
doaj   +1 more source