Results 11 to 20 of about 3,647 (206)
Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis
Autoimmunity, 2020 Rheumatoid arthritis (RA) is an autoimmune disease, which compromises the synovial membrane resulting in chronic inflammation. Ficolins are key proteins of the lectin pathway of complement able to recognize pathogen-associated molecular patterns ...
Cristhine Pieczarka +7 more
doaj +3 more sources
Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1 [PDF]
Cell Communication and SignalingBackground Macrophages are key inflammatory immune cells that orchestrate the initiation and progression of autoimmune diseases. The characters of macrophage in diseases are determined by its phenotype in response to the local microenvironment.
Li-Wen Zhu +8 more
doaj +2 more sources
Mannose-Binding Lectin Regulates Host Resistance and Pathology during Experimental Infection with Trypanosoma cruzi [PDF]
, 2012 Mannose-binding lectin (MBL) is a humoral pattern-recognition molecule important for host defense. Although recent genetic studies suggest an involvement of MBL/MASP2-associated pathways in Chagas’ disease, it is currently unknown whether MBL plays a ...
Báfica, André +8 more
core +14 more sources
Complement and transplant-associated thrombotic microangiopathy: Current and future approaches. [PDF]
HemasphereHemaSphere, Volume 10, Issue 4, April 2026.
Cugno M, Onida F, Lämmle B.
europepmc +2 more sources
Circulating Ficolin-2 and Ficolin-3 Form Heterocomplexes [PDF]
The Journal of Immunology, 2020 Abstract The complement system constitutes an important part of the innate immune system. The collectins and the ficolins are soluble pattern recognition molecules that contribute to complement activation via the lectin pathway. During previous experiments with ficolin-2 and ficolin-3, we have observed that the molecules may interact. We
Ida Jarlhelt +5 more
openaire +3 more sources
Journal of Innate Immunity, 2010 Udgivelsesdato: 2009 ...
Garred, Peter, Borregaard, Niels
openaire +3 more sources
The Genetics of Ficolins [PDF]
Journal of Innate Immunity, 2009 Ficolins constitute a family of proteins whose biological role has been an enigma for many years. Over the past few years it has become evident that ficolins are part of the innate immune system and function as recognition molecules in the complement system.
Garred, Peter +6 more
openaire +4 more sources
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Human L-Ficolin (Ficolin-2) and Its Clinical Significance [PDF]
Journal of Biomedicine and Biotechnology, 2012 Human L-ficolin (P35, ficolin-2) is synthesised in the liver and secreted into the bloodstream where it is one of the major pattern recognition molecules of plasma/serum. Like other ficolins, it consists of a collagen-like tail region linked to a fibrinogen-related globular head; a basic triplet subunit arises via a collagen-like triple helix, and this
Kilpatrick, David C., Chalmers, James D.
openaire +4 more sources