Results 11 to 20 of about 1,942 (166)
Unveiling ficolins: diagnostic and prognostic biomarkers linked to the Tumor Microenvironment in Lung Cancer [PDF]
World Journal of Surgical OncologyBackground Ficolins (FCNs) are a family of proteins, comprising FCN1, FCN2 and FCN3, and integral to the immune system which have been implicated in the onset and progression of tumors.
Zeyu Zhang +6 more
doaj +2 more sources
Ficolin-1 in pediatric Plasmodium falciparum malaria and its possible role in parasite clearance and anemia [PDF]
Infection and ImmunityPlasmodium falciparum malaria causes significant disease, especially in young children. A successful immune response to P. falciparum is a major determinant of clinical outcome.
Di Zheng +15 more
doaj +2 more sources
Genomics, 2004 Ficolin is a collagenous lectin which plays a crucial role in innate immunity. Three and two ficolins have been identified in human and mice, respectively. To identify the mouse homologue of human H-ficolin and to elucidate the orthology between mouse ficolins A/B and human L-/M-ficolins, the gene structures were explored.
Minoru Takahashi, Teizo Fujita
exaly +3 more sources
New and Emerging Biomarkers in Chronic Kidney Disease [PDF]
BiomedicinesChronic kidney disease (CKD) represents a major and widespread global health challenge. It affects over 800 million people worldwide, which is approximately 13% of the world’s population.
Mikołaj Dopierała +5 more
doaj +2 more sources
Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1 [PDF]
Journal of Translational MedicineBackground Ficolins were originally identified as proteins that bind to transforming growth factor-β1 (TGF-β1). They are capable of activating the complement system through lectin pathway for immune system protection. Ficolin-2 and 3 have been identified
Pengfei Gao +7 more
doaj +2 more sources
The Role of Ficolins in Innate Immunity
Immunobiology, 2002 Ficolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain and are found in varying tissues. Ficolins present in sera have a lectin activity toward N-acetylglucosamine through their fibrinogen-like domains. The domain organizations between ficolins and mannose-binding lectin (MBL) are very similar in that both ...
Teizo Fujita, Misao Matsushita
exaly +3 more sources
Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1 [PDF]
Cell Communication and SignalingBackground Macrophages are key inflammatory immune cells that orchestrate the initiation and progression of autoimmune diseases. The characters of macrophage in diseases are determined by its phenotype in response to the local microenvironment.
Li-Wen Zhu +8 more
doaj +2 more sources
Circulating Ficolin-2 and Ficolin-3 Form Heterocomplexes [PDF]
The Journal of Immunology, 2020 Abstract The complement system constitutes an important part of the innate immune system. The collectins and the ficolins are soluble pattern recognition molecules that contribute to complement activation via the lectin pathway. During previous experiments with ficolin-2 and ficolin-3, we have observed that the molecules may interact. We
Ida Jarlhelt +5 more
openaire +3 more sources
Journal of Innate Immunity, 2010 Udgivelsesdato: 2009 ...
Garred, Peter, Borregaard, Niels
openaire +3 more sources
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source