Results 31 to 40 of about 1,942 (166)

Allelic lineages of the ficolin genes (FCNs) are passed from ancestral to descendant primates.

PLoS ONE, 2011
The ficolins recognize carbohydrates and acetylated compounds on microorganisms and dying host cells and are able to activate the lectin pathway of the complement system.
Tina Hummelshøj, Janna Nissen, Lea Munthe-Fog, Claus Koch, Mads Frost Bertelsen, Peter Garred   +5 more
doaj   +1 more source

Low levels of mannan-binding lectin or ficolins are not associated with an increased risk of cytomegalovirus disease in HIV-infected patients.

PLoS ONE, 2013
BackgroundIn HIV-infected patients, prediction of Cytomegalovirus (CMV) disease remains difficult. A protective role of mannan-binding lectin (MBL) and ficolins against CMV disease has been reported after transplantation, but the impact in HIV-infected ...
Adrian Egli, Juliane Schäfer, Michael Osthoff, Steffen Thiel, Christina Mikkelsen, Andri Rauch, Hans H Hirsch, Heiner C Bucher, James Young, Jens C Jensenius, Manuel Battegay, Marten Trendelenburg, Swiss HIV Cohort Study   +12 more
doaj   +1 more source

Mouse mannose-binding lectin-A and ficolin-A inhibit lipopolysaccharide-mediated pro-inflammatory responses on mast cells [PDF]

BMB Reports, 2013
It is unknown how soluble pattern-recognition receptors inblood, such as mannose-binding lectin (MBL) and ficolins,modulate mast cell-mediated inflammatory responses. Weinvestigate how mouse MBL-A or ficolin-A regulate mouse bonemarrow-derived mast cells
Ying Jie Ma, Hee Jung Kang, Ji Yeon Kim, Peter Garred, Myung-Shik Lee, Bok Luel Lee   +5 more
doaj   +1 more source

Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations

Frontiers in Immunology, 2020
A prospective study of 312 patients [194 with multiple myeloma (MM) and 118 with lymphomas (LYMPH)] receiving high-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HSCT) was conducted.
Anna S. Świerzko, Mateusz Michalski, Anna Sokołowska, Mateusz Nowicki, Agnieszka Szala-Poździej, Łukasz Eppa, Iwona Mitrus, Anna Szmigielska-Kapłon, Małgorzata Sobczyk-Kruszelnicka, Katarzyna Michalak, Aleksandra Gołos, Agnieszka Wierzbowska, Sebastian Giebel, Krzysztof Jamroziak, Marek L. Kowalski, Olga Brzezińska, Olga Brzezińska, Steffen Thiel, Misao Matsushita, Jens C. Jensenius, Gabriela Gajek, Maciej Cedzyński   +21 more
doaj   +1 more source

Essential Roles for Mannose-Binding Lectin-Associated Serine Protease-1/3 in the Development of Lupus-Like Glomerulonephritis in MRL/lpr Mice

Frontiers in Immunology, 2018
The complement system, composed of the three activation pathways, has both protective and pathogenic roles in the development of systemic lupus erythematosus (or lupus), a prototypic autoimmune disease.
Takeshi Machida, Natsumi Sakamoto, Yumi Ishida, Minoru Takahashi, Teizo Fujita, Hideharu Sekine   +5 more
doaj   +1 more source

Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. [PDF]

PLoS ONE, 2016
Immunoproteasomes, harboring the active site subunits β5i/LMP7, β1i/LMP2, and β2i/MECL1 exert protective, regulatory or modulating functions during infection-induced immune responses.
Felicia Kirschner, Katrin Reppe, Nadine Andresen, Martin Witzenrath, Frédéric Ebstein, Peter-Michael Kloetzel   +5 more
doaj   +1 more source

Functional analysis of Ficolin-3 mediated complement activation.

PLoS ONE, 2010
The recognition molecules of the lectin complement pathway are mannose-binding lectin and Ficolin -1, -2 and -3. Recently deficiency of Ficolin-3 was found to be associated with life threatening infections.
Estrid Hein, Christian Honoré, Mikkel-Ole Skjoedt, Lea Munthe-Fog, Tina Hummelshøj, Peter Garred   +5 more
doaj   +1 more source

The Lectin Pathway of Complement and Rheumatic Heart Disease

Frontiers in Pediatrics, 2015
The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry.
Marcia Holsbach Beltrame, Sandra Jeremias Catarino, Isabela eGoeldner, Angelica Beate Winter Boldt, Iara eDe Messias Reason   +4 more
doaj   +1 more source

Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults

Scientific Reports, 2020
We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as ...
Anna Sokołowska, Anna S. Świerzko, Gabriela Gajek, Aleksandra Gołos, Mateusz Michalski, Mateusz Nowicki, Agnieszka Szala-Poździej, Anna Wolska-Washer, Olga Brzezińska, Agnieszka Wierzbowska, Krzysztof Jamroziak, Marek L. Kowalski, Steffen Thiel, Misao Matsushita, Jens C. Jensenius, Maciej Cedzyński   +15 more
doaj   +1 more source

The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System

Frontiers in Immunology, 2020
Lung diseases are among the leading causes of morbidity and mortality. Complement activation may prevent a variety of respiratory infections, but on the other hand, could exacerbate tissue damage or contribute to adverse side effects. In this review, the
Anna S. Świerzko, Maciej Cedzyński
doaj   +1 more source