Results 31 to 40 of about 3,647 (206)

Frequency and distribution of FCN2 and FCN3 functional variants among MBL2 genotypes. [PDF]

, 2016
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Arnardottir, Margret, Bjarnadottir, Helga, Ludviksson, Bjorn Runar   +2 more
core   +1 more source

Ficolin-2 and ficolin-3 in women with malignant and benign ovarian tumours [PDF]

Cancer Immunology, Immunotherapy, 2013
Ficolins are serum pattern recognition molecules. They have opsonic properties and are able to activate complement via the lectin pathway. This paper reports investigations concerning ficolin-2 and ficolin-3 in ovarian cancer (OC). Their serum levels, single nucleotide polymorphisms of the corresponding FCN2 and FCN3 genes and specific mRNA expression ...
Szala, Agnieszka, Sawicki, Sambor, Swierzko, Anna St., Szemraj, Janusz, Sniadecki, Marcin, Michalski, Mateusz, Kaluzynski, Andrzej, Lukasiewicz, Jolanta, Maciejewska, Anna, Wydra, Dariusz, Kilpatrick, David C., Matsushita, Misao, Cedzynski, Maciej   +12 more
openaire   +2 more sources

Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo

Scientific Reports, 2017
Ficolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of infection.
Ninette Genster, Olga Østrup, Camilla Schjalm, Tom Eirik Mollnes, Jack B. Cowland, Peter Garred   +5 more
doaj   +1 more source

Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses

Viruses, 2021
The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators.
Valarmathy Murugaiah, Praveen M. Varghese, Nazar Beirag, Syreeta De Cordova, Robert B. Sim, Uday Kishore   +5 more
doaj   +1 more source

Molecular interaction between natural IgG and ficolin - Mechanistic insights on adaptive-innate immune crosstalk [PDF]

, 2014
10.1038/srep03675Scientific ...
Anand, Ganesh Srinivasan, Ding, Jeakling, Panda, Saswati, Yang, Lifeng, Zhang, Jing   +4 more
core   +1 more source

Serum MASP-1 in complex with MBL activates endothelial cells. [PDF]

, 2014
The complement system plays an important role in the induction of inflammation. In this study we demonstrate that the initiation complexes of the lectin pathway, consisting of mannose-binding lectin (MBL) and associated serine proteases (MASPs) elicit ...
Ambrus, Balázs Major, Beinrohr, Dahl, Davis, Degn, Degn, Degn, Degn, Dobó, Dobó, Dobó, Endre Schwaner, Erika Kajdácsi, Gulla, Gál, Hansen, Heja, Heja, Hess, Jensenius, János Rigó, József Dobó, Kidmose, Kocsis, László Cervenak, Matsushita, Matsushita, Matsushita, Megyeri, Megyeri, Márton Megyeri, Møller-Kristensen, Oroszlán, Paréj, Paréj, Péter Gál, Péter K. Jani, Péter Závodszky, Ricklin, Saeed, Skjoedt, Steffen Thiel, Stover, Takahashi, Thiel, Thiel, Thiel, Thiel, Thiel, van der Pol   +50 more
core   +1 more source

Allelic lineages of the ficolin genes (FCNs) are passed from ancestral to descendant primates.

PLoS ONE, 2011
The ficolins recognize carbohydrates and acetylated compounds on microorganisms and dying host cells and are able to activate the lectin pathway of the complement system.
Tina Hummelshøj, Janna Nissen, Lea Munthe-Fog, Claus Koch, Mads Frost Bertelsen, Peter Garred   +5 more
doaj   +1 more source

Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations

Frontiers in Immunology, 2020
A prospective study of 312 patients [194 with multiple myeloma (MM) and 118 with lymphomas (LYMPH)] receiving high-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HSCT) was conducted.
Anna S. Świerzko, Mateusz Michalski, Anna Sokołowska, Mateusz Nowicki, Agnieszka Szala-Poździej, Łukasz Eppa, Iwona Mitrus, Anna Szmigielska-Kapłon, Małgorzata Sobczyk-Kruszelnicka, Katarzyna Michalak, Aleksandra Gołos, Agnieszka Wierzbowska, Sebastian Giebel, Krzysztof Jamroziak, Marek L. Kowalski, Olga Brzezińska, Olga Brzezińska, Steffen Thiel, Misao Matsushita, Jens C. Jensenius, Gabriela Gajek, Maciej Cedzyński   +21 more
doaj   +1 more source

The distribution of lectins across the phylum Nematoda : a genome-wide search [PDF]

, 2017
Nematodes are a very diverse phylum that has adapted to nearly every ecosystem. They have developed specialized lifestyles, dividing the phylum into free-living, animal, and plant parasitic species. Their sheer abundance in numbers and presence in nearly
Bauters, Lander, Gheysen, Godelieve, Naalden, Diana   +2 more
core   +3 more sources

Mouse mannose-binding lectin-A and ficolin-A inhibit lipopolysaccharide-mediated pro-inflammatory responses on mast cells [PDF]

BMB Reports, 2013
It is unknown how soluble pattern-recognition receptors inblood, such as mannose-binding lectin (MBL) and ficolins,modulate mast cell-mediated inflammatory responses. Weinvestigate how mouse MBL-A or ficolin-A regulate mouse bonemarrow-derived mast cells
Ying Jie Ma, Hee Jung Kang, Ji Yeon Kim, Peter Garred, Myung-Shik Lee, Bok Luel Lee   +5 more
doaj   +1 more source