Results 51 to 60 of about 1,942 (166)
Advanced Science, EarlyView.Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou +10 more
wiley +1 more source
Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature
Advanced Science, EarlyView.A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo +14 more
wiley +1 more source
Circulating ficolin-2 and ficolin-3 in normal pregnancy and pre-eclampsia
Clinical and Experimental Immunology, 2012 Summary Ficolins are soluble molecules of the innate immune system that recognize carbohydrate molecules on microbial pathogens, apoptotic and necrotic cells. They act through two distinct routes: initiating the lectin pathway of complement activation and mediating a primitive opsonophagocytosis.
Halmos, Amrita +5 more
openaire +4 more sources
H-ficolin (ficolin-3) concentrations and FCN3 gene polymorphism in neonates
Immunobiology, 2012 Serum H-ficolin (ficolin-3) concentrations (n=613) and FCN3 genotypes (n=529) from a large group of neonates are presented. Both pre-term deliveries and low birthweight (independently of gestational age) were significantly associated with low H-ficolin concentrations but not with heterozygosity for the FCN3 1637delC frameshift mutation. The presence of
Mateusz, Michalski +12 more
openaire +2 more sources
Experimental Hematology & Oncology, 2021 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric patients after hematopoietic stem cell transplantation.
Eleni Gavriilaki +6 more
doaj +1 more source
M-ficolin in children with cancer
Immunobiology, 2011 M-ficolin (ficolin-1) is a complement-activating pattern-recognition molecule structurally related to mannan-binding lectin. It is produced by monocytes and neutrophils, and is found in serum. Its biological role is largely unknown. We assessed M-ficolin concentration in serum from pediatric cancer patients.
Schlapbach, Luregn J. +6 more
openaire +6 more sources
The Role of Humoral Innate Immunity in Hepatitis C Virus Infection
Viruses, 2012 Infection with Hepatitis C Virus (HCV) causes chronic disease in approximately 80% of cases, resulting in chronic inflammation and cirrhosis. Current treatments are not completely effective, and a vaccine has yet to be developed.
Richard A. Urbanowicz +2 more
doaj +1 more source
Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation
Journal of Arrhythmia, Volume 42, Issue 4, August 2026.Diabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.
Kenshi Yoshimura +9 more
wiley +1 more source
Bipolar Disorders, Volume 28, Issue 5, August 2026.ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders +21 more
wiley +1 more source
The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin. [PDF]
PLoS ONE, 2013 Mannan-binding lectin (MBL), ficolins and collectin-11 are known to associate with three homologous modular proteases, the MBL-Associated Serine Proteases (MASPs). The crystal structures of the catalytic domains of MASP-1 and MASP-2 have been solved, but
Christine Gaboriaud +8 more
doaj +1 more source