Results 31 to 40 of about 1,689,260 (355)

Alternative Pathway Is Involved in Hydrogen Peroxide-Enhanced Cadmium Tolerance in Hulless Barley Roots

Plants, 2021
Hulless barley, grown in the Qinghai Tibet Plateau, has a wide range of environmental stress tolerance. Alternative pathway (AP) and hydrogen peroxide (H2O2) are involved in enhancing plant tolerance to environmental stresses.
Li He, Xiaomin Wang, Xiaofan Na, Ruijun Feng, Qiang He, Shengwang Wang, Cuifang Liang, Lili Yan, Libin Zhou, Yurong Bi   +9 more
doaj   +1 more source

Modeling complement activation on human glomerular microvascular endothelial cells

Frontiers in Immunology, 2023
IntroductionAtypical hemolytic uremic syndrome (aHUS) is a rare kidney disease caused by dysregulation of the complement alternative pathway. The complement dysregulation specifically leads to damage to the glomerular endothelium.
Kes H. Stevens, Laura M. Baas, Thea J. A. M. van der Velden, Romy N. Bouwmeester, Niels van Dillen, Eiske M. Dorresteijn, Arjan D. van Zuilen, Jack F. M. Wetzels, Marloes A. H. M. Michels, Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel   +14 more
doaj   +1 more source

Systematic Review of the Link Between Oxford MEST-C Classification and Complement Activation in IgA Nephropathy

Kidney International Reports
Introduction: IgA nephropathy's (IgAN’s) MEST-C classification relationship with complement activation is still not fully understood because of limited and conflicting evidence.
Gabriel Ștefan, Eric Alamartine, Christophe Mariat, Nicolas Maillard   +3 more
doaj   +1 more source

A novel assay that characterizes properdin function shows neutrophil-derived properdin has a distinct oligomeric distribution

Frontiers in Immunology, 2023
Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore, Smrithi S. Menon, Neeti S. Galwankar, Sadik A. Khuder, Michael K. Pangburn, Viviana P. Ferreira   +5 more
doaj   +1 more source

Alternative final steps in berberine biosynthesis in Coptis japonica cell cultures [PDF]

, 1988
In Coptis japonica cell cultures an alternative pathway has been discovered which leads from (S)-tetrahydrocolumbamine via (S)-canadine to berberine. The two enzymes involved have been partially purified.
Galneder, E., Rüffer, Martina, Tabata, M., Wanner, G., Zenk, Meinhart H.   +4 more
core   +1 more source

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Frontiers in Immunology, 2019
Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the ...
Ramon M. van den Bos, Nicholas M. Pearce, Joke Granneman, T. Harma C. Brondijk, Piet Gros   +4 more
doaj   +1 more source

SARS‐CoV‐2 triggers complement activation through interactions with heparan sulfate

Clinical & Translational Immunology, 2022
Objectives To determine whether SARS‐CoV‐2 can trigger complement activation, the pathways that are involved and the functional significance of the resultant effect.
Martin W Lo, Alberto A Amarilla, John D Lee, Eduardo A Albornoz, Naphak Modhiran, Richard J Clark, Vito Ferro, Mohit Chhabra, Alexander A Khromykh, Daniel Watterson, Trent M Woodruff   +10 more
doaj   +1 more source

Calcium signalling links MYC to NUAK1 [PDF]

, 2018
NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability.
Hedley, A,, Knight, J.R., Monteverde, T., Murphy, D.J., Sansom, O.J., Tait-Mulder, J.   +5 more
core   +1 more source

Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases

Frontiers in Immunology, 2018
Overactivation of the alternative pathway of the complement system is associated with the renal diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Marcin Okrój, Anna M. Blom, Sanne A. W. van Kraaij, Elena B. Volokhina, Elena B. Volokhina, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel   +9 more
doaj   +1 more source

Hijacking Factor H for Complement Immune Evasion

Frontiers in Immunology, 2021
The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira   +3 more
doaj   +1 more source