Results 31 to 40 of about 6,251 (169)

Complement Properdin Determines Disease Activity in MRL/lpr Mice

Medicina, 2020
Background and objects: In systemic lupus erythematosus, circulating immune complexes activate complement and, when trapped in renal capillaries, cause glomerulonephritis.
Hasanain Alaridhee, Azzah Alharbi, Zeayd Saeed, Róisín C. Thomas, Cordula M. Stover   +4 more
doaj   +1 more source

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

eLife, 2020
Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades.
Jie Zhang, Lihong Song, Dennis V Pedersen, Anna Li, John D Lambris, Gregers Rom Andersen, Tom Eirik Mollnes, Ying Jie Ma, Peter Garred   +8 more
doaj   +1 more source

Properdin inhibition ameliorates hepatic ischemia/reperfusion injury without interfering with liver regeneration in mice

Frontiers in Immunology, 2023
Hepatic ischemia/reperfusion injury (IRI) often causes serious complications in liver surgeries, including transplantation. Complement activation seems to be involved in hepatic IRI; however, no complement-targeted intervention has been clinically ...
Jiro Kusakabe, Koichiro Hata, Tetsuya Tajima, Hidetaka Miyauchi, Xiangdong Zhao, Shoichi Kageyama, Tatsuaki Tsuruyama, Etsuro Hatano   +7 more
doaj   +1 more source

Seventy Years Later: Systemic and Local Properdin in Atherosclerosis [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Jean F. Regal, Sherry D. Fleming
doaj   +2 more sources

Prognostic Value of Complement Properdin in Cancer

Frontiers in Immunology, 2021
The complement system is readily triggered by the presence of damage-associated molecular patterns on the surface of tumor cells. The complement alternative pathway provides rapid amplification of the molecular stress signal, leading to complement ...
Alessandro Mangogna, Praveen M. Varghese, Praveen M. Varghese, Chiara Agostinis, Salman H. Alrokayan, Haseeb A. Khan, Cordula M. Stover, Beatrice Belmonte, Anna Martorana, Giuseppe Ricci, Giuseppe Ricci, Roberta Bulla, Uday Kishore   +12 more
doaj   +1 more source

Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation

Frontiers in Immunology, 2020
The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation.
Jin Y. Chen, Neeti S. Galwankar, Heather N. Emch, Smrithi S. Menon, Claudio Cortes, Joshua M. Thurman, Samuel A. Merrill, Robert A. Brodsky, Viviana P. Ferreira   +8 more
doaj   +1 more source

HBSP improves kidney ischemia-reperfusion injury and promotes repair in properdin deficient mice via enhancing phagocytosis of tubular epithelial cells

Frontiers in Immunology, 2023
Phagocytosis plays vital roles in injury and repair, while its regulation by properdin and innate repair receptor, a heterodimer receptor of erythropoietin receptor (EPOR)/β common receptor (βcR), in renal ischaemia-reperfusion (IR) remains unclear ...
Yuanyuan Wu, Yuanyuan Wu, Lili Huang, Wenli Sai, Fei Chen, Yu Liu, Cheng Han, Joanna M. Barker, Zinah D. Zwaini, Mark P. Lowe, Nigel J. Brunskill, Nigel J. Brunskill, Bin Yang, Bin Yang   +13 more
doaj   +1 more source

A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples.

PLoS ONE, 2014
The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. Dysregulation of complement can promote
Diana Pauly, Benedikt M Nagel, Jörg Reinders, Tobias Killian, Matthias Wulf, Susanne Ackermann, Boris Ehrenstein, Peter F Zipfel, Christine Skerka, Bernhard H F Weber   +9 more
doaj   +1 more source

Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans

mBio, 2011
Fungal cell walls are predominantly composed of glucans, mannans, and chitin. Recognition of these glycans by the innate immune system is a critical component of host defenses against the mycoses.
Sarika Agarwal, Charles A. Specht, Haibin Huang, Gary R. Ostroff, Sanjay Ram, Peter A. Rice, Stuart M. Levitz   +6 more
doaj   +1 more source

Structure and function of a family of tick-derived complement inhibitors targeting properdin

Nature Communications, 2022
Properdin is the only known positive regulator of the human complement system, stabilising the convertase C3 in the alternative pathway of complement activation.
Katharina Braunger, Jiyoon Ahn, Matthijs M. Jore, Steven Johnson, Terence T. L. Tang, Dennis V. Pedersen, Gregers R. Andersen, Susan M. Lea   +7 more
doaj   +1 more source