Results 31 to 40 of about 7,301 (203)

Oligomerisation of the complement regulator, properdin [PDF]

, 2020
The complement system provides protection against invading pathogens through lysis, opsonisation and by triggering the inflammatory immune response.
Ahmad A. Alzamami (9130626)
core   +1 more source

Presentation_1_Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy.PPTX [PDF]

, 2019
C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of the alternative pathway (AP) of the complement
Marloes A. H. M. Michels (5056286), Elena B. Volokhina (6847514), Valentina Gracchi (5434847), Lambertus P. W. J. van den Heuvel (6847517), Ramon M. van den Bos (6847502), Sebastian A. Sarlea (6847508), Michiel J. S. Oosterveld (6847511), Sanne A. W. van Kraaij (5056289), Nicole C. A. J. van de Kar (5056280), Thea J. A. M. van der Velden (6847505)   +9 more
core   +1 more source

Subtyping of Properdin Factor B (Bf) by Isoelectrofocusing [PDF]

, 1982
Properdin factor B (Bf) is a polymorphic protein in the human plasma. Two common alleles, BfS, BfF, and two rare alleles, BfF1, BfS1, have been demonstrated in Caucasians.
Tan, S.G., Teng, Y.-S.
core   +1 more source

Protein engineering of human properdin [PDF]

, 1994
Properdin is a serum glycoprotein that upregulates the alternative pathway of complement by stabilizing the C3bBb complex. It also binds sulphated glycoconjugates, such as sulphatide, in vitro.
Higgins, J.M, Higgins, Jonathan M.G.
core   +2 more sources

Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation

Frontiers in Immunology, 2020
The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation.
Jin Y. Chen, Neeti S. Galwankar, Heather N. Emch, Smrithi S. Menon, Claudio Cortes, Joshua M. Thurman, Samuel A. Merrill, Robert A. Brodsky, Viviana P. Ferreira   +8 more
doaj   +1 more source

Anti-properdin antibodies show high avidity towards human properdin. [PDF]

, 2014
The binding strengths of newly generated mAb 1340 as well as commercially available mAb A233 and mAb A235 were tested in an indirect ELISA. MAbs were serially diluted (1,000–0.1 ng/mL) and properdin binding was detected with a peroxidase conjugated anti ...
Tobias Killian (559464), Susanne Ackermann (559466), Boris Ehrenstein (559467), Christine Skerka (105424), Diana Pauly (170378), Matthias Wulf (559465), Bernhard H. F. Weber (162289), Jörg Reinders (559463), Peter F. Zipfel (105431), Benedikt M. Nagel (559462)   +9 more
core   +1 more source

HBSP improves kidney ischemia-reperfusion injury and promotes repair in properdin deficient mice via enhancing phagocytosis of tubular epithelial cells

Frontiers in Immunology, 2023
Phagocytosis plays vital roles in injury and repair, while its regulation by properdin and innate repair receptor, a heterodimer receptor of erythropoietin receptor (EPOR)/β common receptor (βcR), in renal ischaemia-reperfusion (IR) remains unclear ...
Yuanyuan Wu, Yuanyuan Wu, Lili Huang, Wenli Sai, Fei Chen, Yu Liu, Cheng Han, Joanna M. Barker, Zinah D. Zwaini, Mark P. Lowe, Nigel J. Brunskill, Nigel J. Brunskill, Bin Yang, Bin Yang   +13 more
doaj   +1 more source

Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells [PDF]

, 2023
Properdin, the only known positive regulator of the complement system, stabilizes the C3 convertase, thereby increasing its half-life. In contrast to most other complement factors, properdin is mainly produced extrahepatically by myeloid cells.
Essen, M.F. van, Hoven, E.M.P. van den, Bos, R.M. van den, Ruben, J.M., Trouw, L.A., Gijlswijk-Janssen, D.J. van, Schlagwein, N., COMBAT Consortium, Born, J. van den, Lubbers, R., Kooten, C. van   +10 more
core   +5 more sources

Molecular principles of enhanced complement activation by properdin [PDF]

, 2021
The complement system is an important part of our innate immunity. Complement is involved in the clearance of microorganisms, foreign particles and altered host cells. Initiation of complement activation can occur through three pathways.
Bos, Ramon Marijs van den
core   +1 more source

Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model

Medicina, 2021
Background and Objectives: Tumours are often low immunogenic. The role of complement, an innate immune defence system, in tumour control has begun to be elucidated, but findings are conflicting. A role for properdin, an amplifier of complement activation,
Izzat A. M. Al-Rayahi, Lee R. Machado, Cordula M. Stover   +2 more
doaj   +1 more source