Results 31 to 40 of about 8,199 (189)

Complement Factor H-Based Therapeutics: A Comprehensive Overview. [PDF]

Eur J Immunol
Complement factor H is a central regulator of the complement system and thus a target for therapeutic intervention. In this review, we provide an overview of past and current factor H‐based therapeutic concepts and modalities to treat complement‐mediated diseases.
Hamers SMWR, Buter EJ, Pouw RB.
europepmc   +2 more sources

Seventy Years Later: Systemic and Local Properdin in Atherosclerosis. [PDF]

J Am Heart Assoc
Regal JF, Fleming SD.
europepmc   +2 more sources

Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model

Medicina, 2021
Background and Objectives: Tumours are often low immunogenic. The role of complement, an innate immune defence system, in tumour control has begun to be elucidated, but findings are conflicting. A role for properdin, an amplifier of complement activation,
Izzat A. M. Al-Rayahi, Lee R. Machado, Cordula M. Stover   +2 more
doaj   +1 more source

Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans

mBio, 2011
Fungal cell walls are predominantly composed of glucans, mannans, and chitin. Recognition of these glycans by the innate immune system is a critical component of host defenses against the mycoses.
Sarika Agarwal, Charles A. Specht, Haibin Huang, Gary R. Ostroff, Sanjay Ram, Peter A. Rice, Stuart M. Levitz   +6 more
doaj   +1 more source

Structure and function of a family of tick-derived complement inhibitors targeting properdin

Nature Communications, 2022
Properdin is the only known positive regulator of the human complement system, stabilising the convertase C3 in the alternative pathway of complement activation.
Katharina Braunger, Jiyoon Ahn, Matthijs M. Jore, Steven Johnson, Terence T. L. Tang, Dennis V. Pedersen, Gregers R. Andersen, Susan M. Lea   +7 more
doaj   +1 more source

Local release of properdin in the cellular microenvironment: Role in pattern recognition and amplification of the alternative pathway of complement

Frontiers in Immunology, 2013
Properdin, the only positive regulatory protein of the complement system, acts as both a stabilizer of the alternative pathway convertases and as a selective pattern recognition molecule of certain microorganisms and host cells (i.e.
Claudio eCortes, Claudio eCortes, Jennifer A Ohtola, Gurpanna eSaggu, Viviana Patricia Ferreira   +4 more
doaj   +1 more source

Properdin in immunity: In vitro and in vivo investigations.

, 2009
The complement system is one of the defence systems used by the host to protect itself against pathogens. It is divided into three complement pathways: the antibodydependent classical pathway, the lectin pathway and the alternative pathway.
Aline Dupont (628410)
core   +7 more sources

THE PROPERDIN SYSTEM AND IMMUNITY [PDF]

The Journal of Experimental Medicine, 1956
A detailed method for the zymosan assay of properdin is described, together with procedures for the preparation and standardization of reagents employed in the test. The reliability and reproducibility of the assay, as well as its limitations, are discussed.
L, PILLEMER, L, BLUM, I H, LEPOW, L, WURZ, E W, TODD   +4 more
openaire   +3 more sources

Presentation_1_Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy.PPTX

, 2019
C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of the alternative pathway (AP) of the complement
Marloes A. H. M. Michels (5056286), Elena B. Volokhina (6847514), Valentina Gracchi (5434847), Lambertus P. W. J. van den Heuvel (6847517), Ramon M. van den Bos (6847502), Sebastian A. Sarlea (6847508), Michiel J. S. Oosterveld (6847511), Sanne A. W. van Kraaij (5056289), Nicole C. A. J. van de Kar (5056280), Thea J. A. M. van der Velden (6847505)   +9 more
core   +1 more source

Complement Properdin Regulates the Metabolo-Inflammatory Response to a High Fat Diet

Medicina, 2020
Background and objectives: Overnutrition leads to a metabolic and inflammatory response that includes the activation of Complement. Properdin is the only amplifier of complement activation and increases the provision of complement activation products ...
Rόisín C. Thomas, Ramiar Kheder, Hasanain Alaridhee, Naomi Martin, Cordula M. Stover   +4 more
doaj   +1 more source