Results 51 to 60 of about 6,251 (169)
Frontiers in Immunology, 2019 The pathophysiology of late kidney-allograft failure remains complex and poorly understood. Activation of filtered or locally produced complement may contribute to the progression of renal failure through tubular C5b-9 formation.
Rosa G. M. Lammerts +9 more
doaj +1 more source
THE PROPERDIN SYSTEM AND IMMUNITY [PDF]
The Journal of Experimental Medicine, 1956 A detailed method for the zymosan assay of properdin is described, together with procedures for the preparation and standardization of reagents employed in the test. The reliability and reproducibility of the assay, as well as its limitations, are discussed.
Irwin H Lepow +4 more
openaire +2 more sources
Frontiers in Immunology, 2018 Mycobacterium tuberculosis can proficiently enter macrophages and diminish complement activation on its cell surface. Within macrophages, the mycobacterium can suppress macrophage apoptosis and survive within the intracellular environment. Previously, we
Maha Ahmed Al-Mozaini +14 more
doaj +1 more source
Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]
PLoS ONE, 2014 The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers +9 more
doaj +1 more source
Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients
Cells, 2023 Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler +3 more
doaj +1 more source
Properdin: A Novel Target for Neuroprotection in Neonatal Hypoxic-Ischemic Brain Injury
Frontiers in Immunology, 2019 Background: Hypoxic-ischemic (HI) encephalopathy is a major cause of neonatal mortality and morbidity, with a global incidence of 3 per 1,000 live births.
Claudia Sisa +5 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.Sex and the developmental environment shape molecular networks underlying bronchial responsiveness in mice. A methacholine challenge was performed on 13‐week‐old isogenic male and female offspring (+/− developmental particulate matter exposure) to show that males had significantly higher bronchial responsiveness (red arrows) than females.
Razia Zakarya +8 more
wiley +1 more source
Exploring urine:serum fractional excretion ratios as potential biomarkers for lupus nephritis
Frontiers in Immunology, 2022 ObjectivesThe goal of this exploratory study is to determine if urine:serum fractional excretion ratios can outperform the corresponding urinary biomarker proteins in identifying active renal disease in systemic lupus erythematosus (SLE).MethodsThirty ...
Samar A. Soliman +6 more
doaj +1 more source
Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency
European Journal of Immunology, Volume 56, Issue 2, February 2026.We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and
Camille Bougeard +9 more
wiley +1 more source
Antioxidants, 2020 The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD).
Nicole Schäfer +6 more
doaj +1 more source