Results 51 to 60 of about 7,301 (203)

Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier‐On‐Chip and Interfacial Interactions With Human Serum Albumin

Allergy, EarlyView.
Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert, Eyup Bilgi, Reyhan Coban, Pelin Saglam‐Metiner, Basar Dogan, Zeynep Imir‐Tekneci, Suleyman Selim Cinaroglu, Ozlem Goksel, Ceyda Oksel Karakus, Ozlem Yesil‐Celiktas   +9 more
wiley   +1 more source

Studies on relationship between serum properdin and cancer I. A modified method for the assay of serum properdin [PDF]

, 1961
1. Properdin assay which is comparatively sensitive and reproducible has been described. The assay may be called a modified method of properdin assay by HUNTER·HILL and McNALL. 2.
Orita, Kunzo
core   +1 more source

Complement Initiation Varies by Sex in Intestinal Ischemia Reperfusion Injury

Frontiers in Immunology, 2021
Intestinal ischemia reperfusion (IR)-induced tissue injury represents an acute inflammatory response with significant morbidity and mortality. The mechanism of IR-induced injury is not fully elucidated, but recent studies suggest a critical role for ...
Miaomiao Wu, Miaomiao Wu, Jennifer M. Rowe, Sherry D. Fleming   +3 more
doaj   +1 more source

Endothelial Glycocalyx: The Missing Link Between Angiogenic Imbalance in Preeclampsia and Systemic Inflammation in HELLP Syndrome. [PDF]

Compr Physiol
Endothelial glycocalyx may be the missing link between angiogenic factors, inflammatory regulation, and endothelial maternal dysfunction in early‐onset preeclampsia and HELLP syndrome. ABSTRACT The pathophysiology of preeclampsia and HELLP syndrome relies on systemic vascular endothelial dysfunction, resulting from angiogenic imbalance due to abnormal ...
Atallah A, Sarda MN, McCarey C, Massardier J, Huissoud C.   +4 more
europepmc   +2 more sources

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni, Ebba Qviberg, Edward Chaloner, Hayley Lavender, Maisem Laabei   +4 more
wiley   +1 more source

Urinary Properdin and sC5b-9 Are Independently Associated With Increased Risk for Graft Failure in Renal Transplant Recipients

Frontiers in Immunology, 2019
The pathophysiology of late kidney-allograft failure remains complex and poorly understood. Activation of filtered or locally produced complement may contribute to the progression of renal failure through tubular C5b-9 formation.
Rosa G. M. Lammerts, Michele F. Eisenga, Mohammed Alyami, Mohamed R. Daha, Marc A. Seelen, Robert A. Pol, Jacob van den Born, Jan-Stephan Sanders, Stephan J. L. Bakker, Stefan P. Berger   +9 more
doaj   +1 more source

The alternative pathway of complement activation may be involved in the renal damage of human anti-glomerular basement membrane disease. [PDF]

PLoS ONE, 2014
Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally revealed in the kidneys of human anti-GBM disease. Our recent studies demonstrated the pathogenic role of complement activation in renal damage of this ...
Rui Ma, Zhao Cui, Shui-Yi Hu, Xiao-Yu Jia, Rui Yang, Xin Zheng, Jie Ao, Gang Liu, Yun-Hua Liao, Ming-Hui Zhao   +9 more
doaj   +1 more source

Complement Factor H‐Based Therapeutics: A Comprehensive Overview

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Complement factor H is a central regulator of the complement system and thus a target for therapeutic intervention. In this review, we provide an overview of past and current factor H‐based therapeutic concepts and modalities to treat complement‐mediated diseases.
Sebastiaan M. W. R. Hamers, Emmy J. Buter, Richard B. Pouw   +2 more
wiley   +1 more source

Monoclonal antibodies specifically detect properdin in human serum. [PDF]

, 2014
(A) Purified human properdin, human serum, recombinant mouse properdin, human embryonic kidney (HEK) cell supernatant and fetal calf serum were immobilized on an ELISA plate.
Tobias Killian (559464), Susanne Ackermann (559466), Boris Ehrenstein (559467), Christine Skerka (105424), Diana Pauly (170378), Matthias Wulf (559465), Bernhard H. F. Weber (162289), Jörg Reinders (559463), Peter F. Zipfel (105431), Benedikt M. Nagel (559462)   +9 more
core   +1 more source

Human Properdin Modulates Macrophage: Mycobacterium bovis BCG Interaction via Thrombospondin Repeats 4 and 5

Frontiers in Immunology, 2018
Mycobacterium tuberculosis can proficiently enter macrophages and diminish complement activation on its cell surface. Within macrophages, the mycobacterium can suppress macrophage apoptosis and survive within the intracellular environment. Previously, we
Maha Ahmed Al-Mozaini, Maha Ahmed Al-Mozaini, Anthony G. Tsolaki, Munirah Abdul-Aziz, Munirah Abdul-Aziz, Suhair M. Abozaid, Suhair M. Abozaid, Mohammed N. Al-Ahdal, Ansar A. Pathan, Valarmathy Murugaiah, Evgeny M. Makarov, Anuvinder Kaur, Robert B. Sim, Uday Kishore, Lubna Kouser   +14 more
doaj   +1 more source