Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]
PLoS ONE, 2014 The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers +9 more
doaj +1 more source
Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients
Cells, 2023 Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler +3 more
doaj +1 more source
Complement system biomarkers in first episode psychosis [PDF]
, 2019 Several lines of evidence implicate immunological/inflammatory factors in development of schizophrenia. Complement is a key driver of inflammation, and complement dysregulation causes pathology in many diseases.
Di Forti, Marta +8 more
core +2 more sources
Properdin: A Novel Target for Neuroprotection in Neonatal Hypoxic-Ischemic Brain Injury
Frontiers in Immunology, 2019 Background: Hypoxic-ischemic (HI) encephalopathy is a major cause of neonatal mortality and morbidity, with a global incidence of 3 per 1,000 live births.
Claudia Sisa +5 more
doaj +1 more source
Exploring urine:serum fractional excretion ratios as potential biomarkers for lupus nephritis
Frontiers in Immunology, 2022 ObjectivesThe goal of this exploratory study is to determine if urine:serum fractional excretion ratios can outperform the corresponding urinary biomarker proteins in identifying active renal disease in systemic lupus erythematosus (SLE).MethodsThirty ...
Samar A. Soliman +6 more
doaj +1 more source
Antioxidants, 2020 The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD).
Nicole Schäfer +6 more
doaj +1 more source
Linkage analysis in a large kindred with autosomal dominant transmission of polyglandular autoimmune disease type II (Schmidt syndrome) [PDF]
, 1984 Schmidt syndrome (PGA syndrome type II) is a rare condition characterized by polyglandular failure. It is an autosomal dominant trait with variable expressivity that was inherited over four generations in an Indiana kindred.
Biegel, Angenieta A. +4 more
core +2 more sources
Molecular mechanisms of inflammation and tissue injury after major trauma-is complement the "bad guy"? [PDF]
, 2011 Trauma represents the leading cause of death among young people in industrialized countries. Recent clinical and experimental studies have brought increasing evidence for activation of the innate immune system in contributing to the pathogenesis of ...
Miriam D Neher +4 more
core +2 more sources
Frontiers in Immunology, 2018 Development of nanoparticles as tissue-specific drug delivery platforms can be considerably influenced by the complement system because of their inherent pro-inflammatory and tumorigenic consequences.
Lubna Kouser +10 more
doaj +1 more source
The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis [PDF]
, 2016 Concentrations of C4d, C3bBbP and sTCC in synovial fluid.
André Struglics +6 more
core +2 more sources