Results 71 to 80 of about 8,199 (189)
Nature Communications, 2016 Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and ...
Yang Yang +5 more
doaj +1 more source
Frontiers in Endocrinology, 2018 BackgroundThere is increasing evidence for the role of impaired intestinal permeability in obesity and associated metabolic diseases. Zonulin is an established serum marker for intestinal permeability and identical to pre-haptoglobin2.
Lucas Scheffler +11 more
doaj +1 more source
Cellular Communication Networks Mediated by Microglia in Ischemic Stroke
CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.After ischemic stroke, microglia serve as central regulators within the neuroimmune network, engaging in dynamic crosstalk with neurons, astrocytes, vascular endothelial cells, and peripheral immune cells. By releasing cytokines, chemokines, extracellular vesicles, and transmitting mechanical signals, activated microglia coordinate inflammatory ...
Feiyu Ma +5 more
wiley +1 more source
Invasive Meningococcal Disease in a Patient With Complement 7 Deficiency
Journal of General and Family Medicine, Volume 26, Issue 6, Page 646-649, November 2025.ABSTRACT Neisseria meningitidis can cause invasive meningococcal disease (IMD). Individuals with primary complement deficiencies are at a higher risk of developing IMD. However, cases of IMD associated with complement deficiency have rarely been reported in Japan.
Hiroaki Nishioka +2 more
wiley +1 more source
Immunoglobulin A Nephropathy: Molecular Pathogenesis and Targeted Therapy
MedComm, Volume 6, Issue 9, September 2025.The future of IgAN treatment likely involves combining several therapies to target multiple disease mechanisms simultaneously. Clinical trials are ongoing to evaluate the efficacy and safety of various combinations. As our understanding of IgAN pathogenesis evolves, more targeted and personalized treatment strategies are expected to emerge.
Xu‐Jie Zhou
wiley +1 more source
Properdin homeostasis requires turnover of the alternative complement pathway
, 2010 Properdin is a plasma protein and is also released from neutrophil granules following stimulation. At inflammatory sites it can bind bacteria and apoptotic bodies to trigger alternative pathway (AP) activation. Principles governing properdin
John P. Atkinson +2 more
core +1 more source
Study of the variables associated with local complement activation in IgA nephropathy
Nefrología (English Edition), 2017 Objectives: 1. To identify the variables that are associated with urinary levels of properdin, MBL, C4d, and C5b-9 in patients with idiopathic IgA nephropathy. 2. To analyse whether urinary levels of MBL and/or C4d are useful for identifying the presence
Alfons Segarra-Medrano +6 more
doaj +1 more source
Biotic and abiotic factors of bactericidal properties variability of ruminant saliva
BIO Web of Conferences, 2020 The microflora of the oral cavity of domestic ruminants, presented by transitive gram-negative species of bacteria (cocci and sticks) in cows, transient and obligate gram-positive (usually cocci) bacteria in sheep was studied. The lowest contamination of
Gilmutdinov Rustam Y. +3 more
doaj +1 more source
, 1998 Three properdin deficiency phenotypes have been reported--complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin protein (type III)--all associated with increased susceptibility to meningococcal disease. Expression of
Sjöholm, Anders +5 more
core +1 more source
Frontiers in Immunology, 2019 Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of
Dennis V. Pedersen +14 more
doaj +1 more source