Results 71 to 80 of about 7,301 (203)

Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency

European Journal of Immunology, Volume 56, Issue 2, February 2026.
We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and
Camille Bougeard, Eléonore Eskander, Paula Vieira Martins, Joan Bitan, Julia Roquigny, Christèle Kyheng, Tamazoust Guiddir, Véronique Frémeaux‐Bacchi, Cécile Gonnin, Carine ElSissy   +9 more
wiley   +1 more source

The role of properdin in the pathogenesis of murine systemic lupus erythematosus [PDF]

, 2019
In systemic lupus erythematosus (SLE), complement-activating immune complexes (ICs) are central to the immunopathogenesis of disease. Their deposition in kidney initiates an inflammatory response resulting in glomerulonephritis.
Hasanain Y. M. Al Aridhee (7882337)
core   +1 more source

The Properdin System in Mice.

Experimental Biology and Medicine, 1960
SummaryInjection of complement (guinea pig serum) into the laboratory albino mouse failed to alter capacity of these animals to withstand parenterally induced bacterial infection with K. pneumoniae or S. typhimurium. Addition of complement to mouse serum failed to induce bactericidal activity in vitro.
F, MIYA, S, MARCUS, E H, PERKINS
openaire   +2 more sources

Human Properdin Opsonizes Nanoparticles and Triggers a Potent Pro-inflammatory Response by Macrophages without Involving Complement Activation

Frontiers in Immunology, 2018
Development of nanoparticles as tissue-specific drug delivery platforms can be considerably influenced by the complement system because of their inherent pro-inflammatory and tumorigenic consequences.
Lubna Kouser, Basudev Paudyal, Basudev Paudyal, Anuvinder Kaur, Gudrun Stenbeck, Lucy A. Jones, Suhair M. Abozaid, Cordula M. Stover, Emmanuel Flahaut, Robert B. Sim, Uday Kishore   +10 more
doaj   +1 more source

Associations between CSF complement factors and biomarkers of amyloid, tau, neurofilament light chain, and α‐synuclein in AD, DLB, and PD

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background While evidence suggests complement system involvement in Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease (PD), its association with disease biomarkers remains unclear. We investigated the relationship of complement factors with amyloid, tau, NfL, and α‐synuclein in CSF in AD, DLB, PD, and controls.
Marianna Rizzo, Charlotte E. Teunissen, Frederic Brosseron, Sandra Kuhs, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Rejko Krüger, Sara B. Gomes Fernandes, Dag Aarsland, Olga Borejko, Davit Chokoshvili, Wiesje M. van der Flier, Afina W. Lemstra, Betty M. Tijms, Gabor C Petzold, Annika Spottke, Giovanni B. Frisoni, Kathrin Brockmann, Thomas Gasser, Tormod Fladby, Marianne Wettergreen, Frank Jessen, Emrah Düzel, Günter U Höglinger, Claire Chevalier, Rajaraman Krishnan, Pieter Jelle Visser, Stephanie J. B. Vos, the IMI EPND consortium   +29 more
wiley   +1 more source

Systemic properdin concentrations in patient serum compared to healthy controls. [PDF]

, 2014
Serum samples of healthy blood donors (controls, n = 26), patients with age-related macular degeneration (AMD, n = 20), systemic lupus erythematosus (SLE, n = 6), connective tissue diseases (CTD, n = 10), polymyalgia rheumatica (PR, n = 31), rheumatoid ...
Tobias Killian (559464), Susanne Ackermann (559466), Boris Ehrenstein (559467), Christine Skerka (105424), Diana Pauly (170378), Matthias Wulf (559465), Bernhard H. F. Weber (162289), Jörg Reinders (559463), Peter F. Zipfel (105431), Benedikt M. Nagel (559462)   +9 more
core   +1 more source

Unraveling the Molecular Mechanisms Underlying Complement Dysregulation by Nephritic Factors in C3G and IC-MPGN

Frontiers in Immunology, 2018
Membranoproliferative glomerulonephritis (MPGN) was recently classified as C3 glomerulopathies (C3G), and immune-complex (IC) mediated MPGN. Dysregulation of the complement alternative pathway, driven by acquired and/or genetic defects, plays a ...
Roberta Donadelli, Patrizia Pulieri, Rossella Piras, Paraskevas Iatropoulos, Elisabetta Valoti, Ariela Benigni, Giuseppe Remuzzi, Giuseppe Remuzzi, Giuseppe Remuzzi, Marina Noris   +9 more
doaj   +1 more source

Cellular Communication Networks Mediated by Microglia in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
After ischemic stroke, microglia serve as central regulators within the neuroimmune network, engaging in dynamic crosstalk with neurons, astrocytes, vascular endothelial cells, and peripheral immune cells. By releasing cytokines, chemokines, extracellular vesicles, and transmitting mechanical signals, activated microglia coordinate inflammatory ...
Feiyu Ma, Yi Bai, Na Li, Xiangyu Cai, Ruicong Xu, Xiang Cao   +5 more
wiley   +1 more source

Complement activation by tubular cells is mediated by properdin binding [PDF]

, 2008
Activation of filtered complement products on the brush border of the tubular epithelium is thought to be a key factor underlying proteinuria-induced tubulointerstitial injury.
Daha, M.R., Zuidwijk, K., Rabelink, T.J., Siezenga, M.A., Berger, S.P., Gaarkeuken, E.M., Kooten, C. van   +6 more
core  

Properdin: Emerging Roles of a Pattern-Recognition Molecule [PDF]

, 2010
Complement is an innate immune system that is a first line of defense against pathogens and facilitates elimination of apoptotic and injured cells. During complement activation, the complement convertases are assembled on target surfaces and initiate ...
Atkinson, John P, John P. Atkinson, Hourcade, Dennis E, Claudia Kemper, Kemper, Claudia, Dennis E. Hourcade   +5 more
core   +1 more source