Results 71 to 80 of about 6,251 (169)

Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity

Nature Communications, 2016
Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and ...
Yang Yang, Fan Liu, Vojtech Franc, Liem Andhyk Halim, Huub Schellekens, Albert J. R. Heck   +5 more
doaj   +1 more source

Proteomic analysis of plasma proteins during fentanyl withdrawal in ovariectomized female rats with and without estradiol

Journal of Neuroendocrinology, Volume 37, Issue 8, August 2025.
Abstract Evidence from both clinical and preclinical studies indicates that females experience a faster progression to drug addiction and more severe addiction‐related health effects compared with males. Estradiol (E2) plays a critical role in these sex differences.
Patricia Sinclair, Navdeep S. Dhanjal, E. Blair Towers, Wendy J. Lynch, Nadine Kabbani   +4 more
wiley   +1 more source

Widely Used Commercial ELISA Does Not Detect Precursor of Haptoglobin2, but Recognizes Properdin as a Potential Second Member of the Zonulin Family

Frontiers in Endocrinology, 2018
BackgroundThere is increasing evidence for the role of impaired intestinal permeability in obesity and associated metabolic diseases. Zonulin is an established serum marker for intestinal permeability and identical to pre-haptoglobin2.
Lucas Scheffler, Alyce Crane, Henrike Heyne, Anke Tönjes, Dorit Schleinitz, Christian H. Ihling, Michael Stumvoll, Rachel Freire, Maria Fiorentino, Alessio Fasano, Peter Kovacs, John T. Heiker   +11 more
doaj   +1 more source

Regulation of the terminal complement cascade in adipose tissue for control of its volume, cellularity, and fibrosis

Obesity, Volume 33, Issue 5, Page 839-850, May 2025.
Abstract White adipose tissue (WAT) is a reservoir for various pathogens and their products, such as lipopolysaccharides. Therefore, it must be equipped with a defense mechanism connected with the activation of innate immunity. This explains the phenomenon that adipocytes express components of the classical and alternative complement pathways, which ...
Ilja L. Kruglikov, Philipp E. Scherer
wiley   +1 more source

Endothelial damage and complement dysregulation in fetuses from pregnancies complicated by preeclampsia

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 5, Page 829-838, May 2025.
Preeclampsia fetuses show an altered profile of endothelial damage and complement biomarkers, like increased adhesion molecules, prothrombotic state, oxidative stress, and reduced complement membrane attack complex deposition on endothelial cells. Abstract Introduction Our objective was to evaluate the endothelial function profile and complement system
Alex Ramos, Lina Youssef, Patricia Molina, Julia Martinez‐Sanchez, Ana Belen Moreno‐Castaño, Miquel Blasco, Blanca De Moner, Marta Tortajada, Marta Camacho, Maria Borrell, Francesca Crovetto, Marc Pino, Gines Escolar, Enric Carreras, Eduard Gratacos, Maribel Diaz‐Ricart, Marta Palomo, Fatima Crispi   +17 more
wiley   +1 more source

Study of the variables associated with local complement activation in IgA nephropathy

Nefrología (English Edition), 2017
Objectives: 1. To identify the variables that are associated with urinary levels of properdin, MBL, C4d, and C5b-9 in patients with idiopathic IgA nephropathy. 2. To analyse whether urinary levels of MBL and/or C4d are useful for identifying the presence
Alfons Segarra-Medrano, Clara Carnicer-Caceres, Naiara Valtierra-Carmeno, Irene Agraz-Pamplona, Natalia Ramos-Terrades, Elías Jatem Escalante, Elena Ostos-Roldan   +6 more
doaj   +1 more source

Biotic and abiotic factors of bactericidal properties variability of ruminant saliva

BIO Web of Conferences, 2020
The microflora of the oral cavity of domestic ruminants, presented by transitive gram-negative species of bacteria (cocci and sticks) in cows, transient and obligate gram-positive (usually cocci) bacteria in sheep was studied. The lowest contamination of
Gilmutdinov Rustam Y., Spiridonov Gennady N., Shalamova Guzel G., Pokrovskaya Ekaterina S.   +3 more
doaj   +1 more source

Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

Frontiers in Immunology, 2019
Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of
Dennis V. Pedersen, Trine A. F. Gadeberg, Caroline Thomas, Yong Wang, Nicolas Joram, Rasmus K. Jensen, Sofia M. M. Mazarakis, Margot Revel, Carine El Sissy, Steen V. Petersen, Kresten Lindorff-Larsen, Steffen Thiel, Nick S. Laursen, Véronique Fremeaux-Bacchi, Gregers R. Andersen   +14 more
doaj   +1 more source

properdin

Citation: 'properdin' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13612 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration

mAbs
The bispecific antibody tarperprumig (ALXN1820) was developed as a treatment option for diseases involving dysregulated complement alternative pathway (AP) activity that could be administered in small volumes, either subcutaneously or intravenously ...
Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen, Jeffrey Hunter   +8 more
doaj   +1 more source