Results 81 to 90 of about 7,301 (203)
Invasive Meningococcal Disease in a Patient With Complement 7 Deficiency
Journal of General and Family Medicine, Volume 26, Issue 6, Page 646-649, November 2025.ABSTRACT Neisseria meningitidis can cause invasive meningococcal disease (IMD). Individuals with primary complement deficiencies are at a higher risk of developing IMD. However, cases of IMD associated with complement deficiency have rarely been reported in Japan.
Hiroaki Nishioka +2 more
wiley +1 more source
Nature Communications, 2016 Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and ...
Yang Yang +5 more
doaj +1 more source
Frontiers in Endocrinology, 2018 BackgroundThere is increasing evidence for the role of impaired intestinal permeability in obesity and associated metabolic diseases. Zonulin is an established serum marker for intestinal permeability and identical to pre-haptoglobin2.
Lucas Scheffler +11 more
doaj +1 more source
Immunoglobulin A Nephropathy: Molecular Pathogenesis and Targeted Therapy
MedComm, Volume 6, Issue 9, September 2025.The future of IgAN treatment likely involves combining several therapies to target multiple disease mechanisms simultaneously. Clinical trials are ongoing to evaluate the efficacy and safety of various combinations. As our understanding of IgAN pathogenesis evolves, more targeted and personalized treatment strategies are expected to emerge.
Xu‐Jie Zhou
wiley +1 more source
Aging Cell, Volume 24, Issue 8, August 2025.Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Maria Lastra Cagigas +16 more
wiley +1 more source
Study of the variables associated with local complement activation in IgA nephropathy
Nefrología (English Edition), 2017 Objectives: 1. To identify the variables that are associated with urinary levels of properdin, MBL, C4d, and C5b-9 in patients with idiopathic IgA nephropathy. 2. To analyse whether urinary levels of MBL and/or C4d are useful for identifying the presence
Alfons Segarra-Medrano +6 more
doaj +1 more source
Biotic and abiotic factors of bactericidal properties variability of ruminant saliva
BIO Web of Conferences, 2020 The microflora of the oral cavity of domestic ruminants, presented by transitive gram-negative species of bacteria (cocci and sticks) in cows, transient and obligate gram-positive (usually cocci) bacteria in sheep was studied. The lowest contamination of
Gilmutdinov Rustam Y. +3 more
doaj +1 more source
Carrier detection by microsatellite haplotyping in 10 properdin type 1-deficient families [PDF]
, 1996 Properdin deficiency carrier identification is relevant, because properdin-deficient persons have an increased risk of contracting meningococcal disease. Vaccination against meningococcal disease at a young age may provide protection.
Mannens, M. +5 more
core +1 more source
Studies on relationship between serum properdin and cancer III. Influence of anticancer agents on the serum properdin level [PDF]
, 1961 1. When the various anticancer agents are injected intravenously to normal rabbits and intraperitoneally to normal mice, it seems that the serum properdin levels fall transitorily for some hours after administration with a small dose and then keep rising,
Orita, Kunzo
core +1 more source
Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin. [PDF]
, 2016 Previous studies have shown that complement activation on renal tubular cells is involved in the induction of interstitial fibrosis and cellular injury.
Dixon KO +15 more
core +1 more source