Results 91 to 100 of about 7,301 (203)

The characterisation of the murine gene for properdin [PDF]

, 2000
The three pathways of complement activation lead to the proteolysis of the same component, C3, that will then carry on the enzymatic cascade of the downstream components and the MAC proteins.;In the context of the alternative pathway, the enzyme ...
Lynda. Dupont (7680140)
core  

The role of Properdin in Tumour Development and Cell Recruitment [PDF]

, 2017
Properdin, as the only positive regulator, amplifies complement activation and has been implicated in the tumour response in human lymphoma and carcinoma.
Izzat Abdulsatar Mezher Al-Rayahi (7741547)
core   +2 more sources

Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

Frontiers in Immunology, 2019
Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of
Dennis V. Pedersen, Trine A. F. Gadeberg, Caroline Thomas, Yong Wang, Nicolas Joram, Rasmus K. Jensen, Sofia M. M. Mazarakis, Margot Revel, Carine El Sissy, Steen V. Petersen, Kresten Lindorff-Larsen, Steffen Thiel, Nick S. Laursen, Véronique Fremeaux-Bacchi, Gregers R. Andersen   +14 more
doaj   +1 more source

The Role of Properdin in Zymosan- and Escherichia coli-Induced Complement Activation [PDF]

, 2012
Properdin is well known as an enhancer of the alternative complement amplification loop when C3 is activated, whereas its role as a recognition molecule of exogenous pathogen-associated molecular patterns and initiator of complement activation is less ...
Lindstad, Julie K, Pharo, Anne, Garred, Peter, Müller, Fredrik, Harboe, Morten, Stahl, Gregory L, Mollnes, Tom Erik, Lambris, John D   +7 more
core   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

PhD [PDF]

, 2007
thesisUnder carefully controlled conditions, bovine serum properdin was isolated and partially purified by employing cold ethanol fractionation procedures.
Miya, Fred
core  

Studies on relationship between serum properdin and cancer I. A modified method for the assay of serum properdin [PDF]

1. Properdin assay which is comparatively sensitive and reproducible has been described. The assay may be called a modified method of properdin assay by HUNTER·HILL and McNALL. 2.
Orita, Kunzo
core  

Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration

mAbs
The bispecific antibody tarperprumig (ALXN1820) was developed as a treatment option for diseases involving dysregulated complement alternative pathway (AP) activity that could be administered in small volumes, either subcutaneously or intravenously ...
Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen, Jeffrey Hunter   +8 more
doaj   +1 more source

properdin

Citation: 'properdin' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13612 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Analysis of Complement Deficiency States. With Focus on Molecular Characterization of C4 and Properdin Deficiency. [PDF]

, 1997
Complement deficiency is associated with an increased risk for invasive infection and immune complex disease. Screening for identification of complement-deficient patients is essential and a new ELISA-based procedure for detection of complement ...
Nordin Fredrikson, Gunilla
core