Results 61 to 70 of about 8,199 (189)

Prognostic Value of Complement Properdin in Cancer [PDF]

, 2020
© 2021 Mangogna, Varghese, Agostinis, Alrokayan, Khan, Stover, Belmonte, Martorana, Ricci, Bulla and Kishore. The complement system is readily triggered by the presence of damage-associated molecular patterns on the surface of tumour cells.
Ricci, G, Bulla, R, Kishore, U, Belmonte, B, Varghese, PM, Martorana, A, Mangogna, A, Agostinis, C, Stover, CM, Alrokayan, SH, Khan, HA   +10 more
core   +1 more source

Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway

Scientific Reports, 2022
Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz, Yuchen Lin, Joshua Mbroh, Jonas Winkler, Huan Liao, Marie Lackmann, Annemarie Bungartz, Peter F. Zipfel, Christine Skerka, Harald Neumann   +9 more
doaj   +1 more source

The Properdin System in Mice.

Experimental Biology and Medicine, 1960
SummaryInjection of complement (guinea pig serum) into the laboratory albino mouse failed to alter capacity of these animals to withstand parenterally induced bacterial infection with K. pneumoniae or S. typhimurium. Addition of complement to mouse serum failed to induce bactericidal activity in vitro.
F, MIYA, S, MARCUS, E H, PERKINS
openaire   +2 more sources

Sex and the Developmental Environment Shape Molecular Networks Underlying Bronchial Responsiveness in Mice

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
Sex and the developmental environment shape molecular networks underlying bronchial responsiveness in mice. A methacholine challenge was performed on 13‐week‐old isogenic male and female offspring (+/− developmental particulate matter exposure) to show that males had significantly higher bronchial responsiveness (red arrows) than females.
Razia Zakarya, Baoming Wang, Yik Lung Chan, Dikaia Xenaki, Kin Fai Ho, Hai Guo, Hui Chen, Brian G. Oliver, Christopher O'Neill   +8 more
wiley   +1 more source

Human Properdin Opsonizes Nanoparticles and Triggers a Potent Pro-inflammatory Response by Macrophages without Involving Complement Activation

Frontiers in Immunology, 2018
Development of nanoparticles as tissue-specific drug delivery platforms can be considerably influenced by the complement system because of their inherent pro-inflammatory and tumorigenic consequences.
Lubna Kouser, Basudev Paudyal, Basudev Paudyal, Anuvinder Kaur, Gudrun Stenbeck, Lucy A. Jones, Suhair M. Abozaid, Cordula M. Stover, Emmanuel Flahaut, Robert B. Sim, Uday Kishore   +10 more
doaj   +1 more source

Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency

European Journal of Immunology, Volume 56, Issue 2, February 2026.
We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and
Camille Bougeard, Eléonore Eskander, Paula Vieira Martins, Joan Bitan, Julia Roquigny, Christèle Kyheng, Tamazoust Guiddir, Véronique Frémeaux‐Bacchi, Cécile Gonnin, Carine ElSissy   +9 more
wiley   +1 more source

Studies on relationship between serum properdin and cancer I. A modified method for the assay of serum properdin [PDF]

, 1961
1. Properdin assay which is comparatively sensitive and reproducible has been described. The assay may be called a modified method of properdin assay by HUNTER·HILL and McNALL. 2.
Orita, Kunzo
core   +1 more source

Unraveling the Molecular Mechanisms Underlying Complement Dysregulation by Nephritic Factors in C3G and IC-MPGN

Frontiers in Immunology, 2018
Membranoproliferative glomerulonephritis (MPGN) was recently classified as C3 glomerulopathies (C3G), and immune-complex (IC) mediated MPGN. Dysregulation of the complement alternative pathway, driven by acquired and/or genetic defects, plays a ...
Roberta Donadelli, Patrizia Pulieri, Rossella Piras, Paraskevas Iatropoulos, Elisabetta Valoti, Ariela Benigni, Giuseppe Remuzzi, Giuseppe Remuzzi, Giuseppe Remuzzi, Marina Noris   +9 more
doaj   +1 more source

Oligomerisation of the complement regulator, properdin

, 2020
The complement system provides protection against invading pathogens through lysis, opsonisation and by triggering the inflammatory immune response.
Ahmad A. Alzamami (9130626)
core   +1 more source

Associations between CSF complement factors and biomarkers of amyloid, tau, neurofilament light chain, and α‐synuclein in AD, DLB, and PD

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background While evidence suggests complement system involvement in Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease (PD), its association with disease biomarkers remains unclear. We investigated the relationship of complement factors with amyloid, tau, NfL, and α‐synuclein in CSF in AD, DLB, PD, and controls.
Marianna Rizzo, Charlotte E. Teunissen, Frederic Brosseron, Sandra Kuhs, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Rejko Krüger, Sara B. Gomes Fernandes, Dag Aarsland, Olga Borejko, Davit Chokoshvili, Wiesje M. van der Flier, Afina W. Lemstra, Betty M. Tijms, Gabor C Petzold, Annika Spottke, Giovanni B. Frisoni, Kathrin Brockmann, Thomas Gasser, Tormod Fladby, Marianne Wettergreen, Frank Jessen, Emrah Düzel, Günter U Höglinger, Claire Chevalier, Rajaraman Krishnan, Pieter Jelle Visser, Stephanie J. B. Vos, the IMI EPND consortium   +29 more
wiley   +1 more source