Results 61 to 70 of about 7,301 (203)
Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]
PLoS ONE, 2014 The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers +9 more
doaj +1 more source
Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients
Cells, 2023 Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler +3 more
doaj +1 more source
Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi +13 more
wiley +1 more source
Properdin: A Novel Target for Neuroprotection in Neonatal Hypoxic-Ischemic Brain Injury
Frontiers in Immunology, 2019 Background: Hypoxic-ischemic (HI) encephalopathy is a major cause of neonatal mortality and morbidity, with a global incidence of 3 per 1,000 live births.
Claudia Sisa +5 more
doaj +1 more source
Alcohol, Clinical and Experimental Research, Volume 50, Issue 6, June 2026.Patients with alcohol‐associated hepatitis (AH) and alcohol‐cirrhosis (AC) show perturbations in complement. Complement activation pathways are perturbed in the urine of patients with AH and AC, and distinguish severe AH from AC. Complement perturbations can help physicians and researchers to understand the liver–kidney crosstalk in severe AH and AC ...
Luan Prado +11 more
wiley +1 more source
Properdin in immunity : in vitro and in vivo investigations [PDF]
, 2009 The complement system is one of the defence systems used by the host to protect itself against pathogens. It is divided into three complement pathways: the antibodydependent classical pathway, the lectin pathway and the alternative pathway.
Dupont, Aline, Stover, Cordula
core +2 more sources
Exploring urine:serum fractional excretion ratios as potential biomarkers for lupus nephritis
Frontiers in Immunology, 2022 ObjectivesThe goal of this exploratory study is to determine if urine:serum fractional excretion ratios can outperform the corresponding urinary biomarker proteins in identifying active renal disease in systemic lupus erythematosus (SLE).MethodsThirty ...
Samar A. Soliman +6 more
doaj +1 more source
Protective role for properdin in progression of experimental murine atherosclerosis.
PLoS ONE, 2014 Genetic, dietary and immune factors contribute to the pathogenesis of atherosclerosis in humans and mice. Complement activation is an integral part of the innate immune defence but also shapes cellular responses and influences directly triglyceride ...
Tanja Steiner +9 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.Sex and the developmental environment shape molecular networks underlying bronchial responsiveness in mice. A methacholine challenge was performed on 13‐week‐old isogenic male and female offspring (+/− developmental particulate matter exposure) to show that males had significantly higher bronchial responsiveness (red arrows) than females.
Razia Zakarya +8 more
wiley +1 more source
Scientific Reports, 2022 Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz +9 more
doaj +1 more source