Results 61 to 70 of about 10,387 (198)

Properdin deficiency or anti-properdin treatment ameliorates disease in the C3 gain-of-function mouse model of atypical haemolytic uraemic syndrome

Frontiers in Immunology
IntroductionWe have previously shown that the C3D1115N mouse, engineered around a single point mutation in C3 associated with atypical haemolytic uraemic syndrome (aHUS) in man, fully recapitulates the clinical disease. In this study, we investigated the
Grace Mallett, Grace Mallett, Ola Kamala, Ola Kamala, Isabel Y. Pappworth, Isabel Y. Pappworth, Kate Smith-Jackson, Kate Smith-Jackson, Beth G. Gibson, Beth G. Gibson, Muhammad Asif, Muhammad Asif, Harriet Denton, Harriet Denton, Charlotte Cox, Patrick Walsh, Patrick Walsh, David Kavanagh, David Kavanagh, Kevin J. Marchbank, Kevin J. Marchbank   +20 more
doaj   +1 more source

Enhancement of platelet response to immune complexes and IgG aggregates by lipid A-rich bacterial lipopolysaccharides. [PDF]

, 1978
The effect of the common lipid moiety of bacterial LPS on secretion from washed human platelets has been studied. The lipid A-rich LPS of S. minnesota R595 and a lipid A preparation both potentiated platelet serotonin secretion in response to IgG ...
Ginsberg, MH, Henson, PM
core   +1 more source

Unraveling the Molecular Mechanisms Underlying Complement Dysregulation by Nephritic Factors in C3G and IC-MPGN

Frontiers in Immunology, 2018
Membranoproliferative glomerulonephritis (MPGN) was recently classified as C3 glomerulopathies (C3G), and immune-complex (IC) mediated MPGN. Dysregulation of the complement alternative pathway, driven by acquired and/or genetic defects, plays a ...
Roberta Donadelli, Patrizia Pulieri, Rossella Piras, Paraskevas Iatropoulos, Elisabetta Valoti, Ariela Benigni, Giuseppe Remuzzi, Giuseppe Remuzzi, Giuseppe Remuzzi, Marina Noris   +9 more
doaj   +1 more source

Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway

Scientific Reports, 2022
Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz, Yuchen Lin, Joshua Mbroh, Jonas Winkler, Huan Liao, Marie Lackmann, Annemarie Bungartz, Peter F. Zipfel, Christine Skerka, Harald Neumann   +9 more
doaj   +1 more source

Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damage [PDF]

, 2014
BACKGROUND: Urinary (U)-complement components have been detected in patients with proteinuric renal diseases, and complement activation via the alternative pathway (AP) is believed to play a role in renal tubular damage.
Atsuko Hisada, Daisuke Honda, Hiroyuki Inoshita, Hiyori Suzuki, Isao Ohsawa, Mamiko Shimamoto, Nobuyuki Sato, Satoshi Horikoshi, Seiji Nagamachi, Yasuhiko Tomino, Yoshio Shimizu   +10 more
core   +1 more source

Characterization, cloning and immunogenicity of antigens released by lung-stage larvae of Schistosoma mansoni [PDF]

, 1999
Lung-stage schistosomula are the target of protective immunity in mice vaccinated with attenuated cercariae of Schistosoma mansoni. Therefore, proteins present at this developmental stage, and in particular those which are secreted, are a potential ...
Coulson, P S, Harrop, R, Wilson, R A
core   +1 more source

Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity

Nature Communications, 2016
Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and ...
Yang Yang, Fan Liu, Vojtech Franc, Liem Andhyk Halim, Huub Schellekens, Albert J. R. Heck   +5 more
doaj   +1 more source

Widely Used Commercial ELISA Does Not Detect Precursor of Haptoglobin2, but Recognizes Properdin as a Potential Second Member of the Zonulin Family

Frontiers in Endocrinology, 2018
BackgroundThere is increasing evidence for the role of impaired intestinal permeability in obesity and associated metabolic diseases. Zonulin is an established serum marker for intestinal permeability and identical to pre-haptoglobin2.
Lucas Scheffler, Alyce Crane, Henrike Heyne, Anke Tönjes, Dorit Schleinitz, Christian H. Ihling, Michael Stumvoll, Rachel Freire, Maria Fiorentino, Alessio Fasano, Peter Kovacs, John T. Heiker   +11 more
doaj   +1 more source

Immunologic aspects of the nephrotic syndrome [PDF]

, 1973
The nephrotic syndrome is a clinical entity characterized by proteinuria, hypoalbuminemia, edema and hyperlipidemia. All the features of this syndrome are ultimately related to increased permeability of the glomerular capillary to protein.
Michael, Alfred F., McLean, Robert H., Roy, L.Paul, Westberg, N.Gunnar, Hoyer, John R., Fish, Alfred J., Vernier, Robert L.   +6 more
core   +4 more sources

Complement in patients receiving maintenance hemodialysis: functional screening and quantitative analysis [PDF]

, 2010
Background The complement system is vital for innate immunity and is implicated in the pathogenesis of inflammatory diseases and the mechanism of host defense. Complement deficiencies occasionally cause life-threatening diseases.
Hiroyuki Inoshita, Isao Ohsawa, Gaku Kusaba, Masaya Ishii, Kisara Onda, Satoshi Horikoshi, Hiroyuki Ohi, Yasuhiko Tomino   +7 more
core   +2 more sources