Die Wirkung des Komplementregulators Properdin auf gestresste retinale Pigmentepithelzellen [PDF]
, 2020 Der Lichteinfall im Auge, der uns die visuelle Wahrnehmung unserer Umgebung ermöglicht, führt in der Retina zu einer Belastung der Zellen mit oxidativem Stress.
Reichenthaler, Maria Theresa
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Properdin homeostasis requires turnover of the alternative complement pathway [PDF]
, 2010 Properdin is a plasma protein and is also released from neutrophil granules following stimulation. At inflammatory sites it can bind bacteria and apoptotic bodies to trigger alternative pathway (AP) activation. Principles governing properdin
John P. Atkinson +2 more
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Structure and function of a family of tick-derived complement inhibitors targeting properdin
Nature Communications, 2022 Properdin is the only known positive regulator of the human complement system, stabilising the convertase C3 in the alternative pathway of complement activation.
Katharina Braunger +7 more
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Prognostic Value of Complement Properdin in Cancer [PDF]
, 2020 © 2021 Mangogna, Varghese, Agostinis, Alrokayan, Khan, Stover, Belmonte, Martorana, Ricci, Bulla and Kishore. The complement system is readily triggered by the presence of damage-associated molecular patterns on the surface of tumour cells.
Ricci, G +10 more
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Characterisation of the properdin-deficient immune phenotype [PDF]
, 2018 Properdin (complement factor P) is a conserved serum glycoprotein of the immune defence. It plays a role in strengthening the activation of complement, a system of proteins important in the first line defence against infection. Properdin is active in the
Cordula M. Stover (7117046) +1 more
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THE PROPERDIN SYSTEM AND IMMUNITY [PDF]
The Journal of Experimental Medicine, 1956 A detailed method for the zymosan assay of properdin is described, together with procedures for the preparation and standardization of reagents employed in the test. The reliability and reproducibility of the assay, as well as its limitations, are discussed.
Irwin H Lepow +4 more
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Complement Properdin Regulates the Metabolo-Inflammatory Response to a High Fat Diet
Medicina, 2020 Background and objectives: Overnutrition leads to a metabolic and inflammatory response that includes the activation of Complement. Properdin is the only amplifier of complement activation and increases the provision of complement activation products ...
Rόisín C. Thomas +4 more
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Expression of properdin in complete and incomplete deficiency: normal in vitro synthesis by monocytes in two cases with properdin deficiency type II due to distinct mutations [PDF]
, 1998 Three properdin deficiency phenotypes have been reported--complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin protein (type III)--all associated with increased susceptibility to meningococcal disease. Expression of
Sjöholm, Anders +5 more
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Frontiers in Immunology, 2019 Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the ...
Ramon M. van den Bos +4 more
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Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus. [PDF]
PLoS ONE, 2008 BACKGROUND: Ticks are blood feeding arachnids that characteristically take a long blood meal. They must therefore counteract host defence mechanisms such as hemostasis, inflammation and the immune response.
Bernard Couvreur +11 more
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