Results 41 to 50 of about 6,251 (169)

Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model

Medicina, 2021
Background and Objectives: Tumours are often low immunogenic. The role of complement, an innate immune defence system, in tumour control has begun to be elucidated, but findings are conflicting. A role for properdin, an amplifier of complement activation,
Izzat A. M. Al-Rayahi, Lee R. Machado, Cordula M. Stover   +2 more
doaj   +1 more source

Endothelial Glycocalyx: The Missing Link Between Angiogenic Imbalance in Preeclampsia and Systemic Inflammation in HELLP Syndrome. [PDF]

Compr Physiol
Endothelial glycocalyx may be the missing link between angiogenic factors, inflammatory regulation, and endothelial maternal dysfunction in early‐onset preeclampsia and HELLP syndrome. ABSTRACT The pathophysiology of preeclampsia and HELLP syndrome relies on systemic vascular endothelial dysfunction, resulting from angiogenic imbalance due to abnormal ...
Atallah A, Sarda MN, McCarey C, Massardier J, Huissoud C.   +4 more
europepmc   +2 more sources

Properdin levels in human sepsis

Frontiers in Immunology, 2015
Properdin is a normal serum protein which increases the production of complement activation products by binding to C3b integral to convertase complexes and amplifying their activity at the site of activation.
Cordula M Stover, John eMcDonald, Simon eByrne, David G Lambert, Jonathan eThompson   +4 more
doaj   +1 more source

Complement Properdin Regulates the Metabolo-Inflammatory Response to a High Fat Diet

Medicina, 2020
Background and objectives: Overnutrition leads to a metabolic and inflammatory response that includes the activation of Complement. Properdin is the only amplifier of complement activation and increases the provision of complement activation products ...
Rόisín C. Thomas, Ramiar Kheder, Hasanain Alaridhee, Naomi Martin, Cordula M. Stover   +4 more
doaj   +1 more source

Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus. [PDF]

PLoS ONE, 2008
BACKGROUND: Ticks are blood feeding arachnids that characteristically take a long blood meal. They must therefore counteract host defence mechanisms such as hemostasis, inflammation and the immune response.
Bernard Couvreur, Jérôme Beaufays, Cédric Charon, Kathia Lahaye, François Gensale, Valérie Denis, Benoît Charloteaux, Yves Decrem, Pierre-Paul Prévôt, Michel Brossard, Luc Vanhamme, Edmond Godfroid   +11 more
doaj   +1 more source

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Frontiers in Immunology, 2019
Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the ...
Ramon M. van den Bos, Nicholas M. Pearce, Joke Granneman, T. Harma C. Brondijk, Piet Gros   +4 more
doaj   +1 more source

The alternative pathway of complement activation may be involved in the renal damage of human anti-glomerular basement membrane disease. [PDF]

PLoS ONE, 2014
Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally revealed in the kidneys of human anti-GBM disease. Our recent studies demonstrated the pathogenic role of complement activation in renal damage of this ...
Rui Ma, Zhao Cui, Shui-Yi Hu, Xiao-Yu Jia, Rui Yang, Xin Zheng, Jie Ao, Gang Liu, Yun-Hua Liao, Ming-Hui Zhao   +9 more
doaj   +1 more source

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Complement Initiation Varies by Sex in Intestinal Ischemia Reperfusion Injury

Frontiers in Immunology, 2021
Intestinal ischemia reperfusion (IR)-induced tissue injury represents an acute inflammatory response with significant morbidity and mortality. The mechanism of IR-induced injury is not fully elucidated, but recent studies suggest a critical role for ...
Miaomiao Wu, Miaomiao Wu, Jennifer M. Rowe, Sherry D. Fleming   +3 more
doaj   +1 more source

Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier‐On‐Chip and Interfacial Interactions With Human Serum Albumin

Allergy, EarlyView.
Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert, Eyup Bilgi, Reyhan Coban, Pelin Saglam‐Metiner, Basar Dogan, Zeynep Imir‐Tekneci, Suleyman Selim Cinaroglu, Ozlem Goksel, Ceyda Oksel Karakus, Ozlem Yesil‐Celiktas   +9 more
wiley   +1 more source