Results 41 to 50 of about 8,199 (189)
Frontiers in Immunology, 2019 Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the ...
Ramon M. van den Bos +4 more
doaj +1 more source
Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus. [PDF]
PLoS ONE, 2008 BACKGROUND: Ticks are blood feeding arachnids that characteristically take a long blood meal. They must therefore counteract host defence mechanisms such as hemostasis, inflammation and the immune response.
Bernard Couvreur +11 more
doaj +1 more source
Subtyping of Properdin Factor B (Bf) by Isoelectrofocusing
, 1982 Properdin factor B (Bf) is a polymorphic protein in the human plasma. Two common alleles, BfS, BfF, and two rare alleles, BfF1, BfS1, have been demonstrated in Caucasians.
Tan, S.G., Teng, Y.-S.
core +1 more source
Allergy, EarlyView.Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert +9 more
wiley +1 more source
Anti-properdin antibodies show high avidity towards human properdin.
, 2014 The binding strengths of newly generated mAb 1340 as well as commercially available mAb A233 and mAb A235 were tested in an indirect ELISA. MAbs were serially diluted (1,000–0.1 ng/mL) and properdin binding was detected with a peroxidase conjugated anti ...
Tobias Killian (559464) +9 more
core +1 more source
Complement Initiation Varies by Sex in Intestinal Ischemia Reperfusion Injury
Frontiers in Immunology, 2021 Intestinal ischemia reperfusion (IR)-induced tissue injury represents an acute inflammatory response with significant morbidity and mortality. The mechanism of IR-induced injury is not fully elucidated, but recent studies suggest a critical role for ...
Miaomiao Wu +3 more
doaj +1 more source
Immunological Reviews, Volume 342, Issue 1, September 2026.ABSTRACT Post‐translational modifications (PTMs) of proteins are essential to maintain homeostasis as many cellular processes rely on reversible PTMs. However, several PTMs, particularly irreversible PTMs in the extracellular space, can contribute to tissue dysfunction, inflammation, and may even trigger the development of autoimmunity against PTM ...
Marleen M. J. van Greevenbroek +1 more
wiley +1 more source
Frontiers in Immunology, 2019 The pathophysiology of late kidney-allograft failure remains complex and poorly understood. Activation of filtered or locally produced complement may contribute to the progression of renal failure through tubular C5b-9 formation.
Rosa G. M. Lammerts +9 more
doaj +1 more source
The alternative pathway of complement activation may be involved in the renal damage of human anti-glomerular basement membrane disease. [PDF]
PLoS ONE, 2014 Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally revealed in the kidneys of human anti-GBM disease. Our recent studies demonstrated the pathogenic role of complement activation in renal damage of this ...
Rui Ma +9 more
doaj +1 more source
Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema
Allergy, Volume 81, Issue 8, Page 2815-2832, August 2026.This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery +25 more
wiley +1 more source