Results 21 to 30 of about 10,387 (198)

Prognostic Value of Complement Properdin in Cancer

Frontiers in Immunology, 2021
The complement system is readily triggered by the presence of damage-associated molecular patterns on the surface of tumor cells. The complement alternative pathway provides rapid amplification of the molecular stress signal, leading to complement ...
Alessandro Mangogna, Praveen M. Varghese, Praveen M. Varghese, Chiara Agostinis, Salman H. Alrokayan, Haseeb A. Khan, Cordula M. Stover, Beatrice Belmonte, Anna Martorana, Giuseppe Ricci, Giuseppe Ricci, Roberta Bulla, Uday Kishore   +12 more
doaj   +1 more source

Studies on relationship between serum properdin and cancer I. A modified method for the assay of serum properdin [PDF]

, 1961
1. Properdin assay which is comparatively sensitive and reproducible has been described. The assay may be called a modified method of properdin assay by HUNTER·HILL and McNALL. 2.
Orita, Kunzo
core   +1 more source

Studies on relationship between serum properdin and cancer III. Influence of anticancer agents on the serum properdin level [PDF]

, 1961
1. When the various anticancer agents are injected intravenously to normal rabbits and intraperitoneally to normal mice, it seems that the serum properdin levels fall transitorily for some hours after administration with a small dose and then keep rising,
Orita, Kunzo
core   +1 more source

Studies on relationship between serum properdin and cancer II. Studies on the serum properdin levels of tumor bearing animals and patients with malignant tumors [PDF]

, 1961
1. The properdin levels in sera from mice bearing Ehrlich ascitic carcinoma and from rabbits with Brown-Pearce carcinoma decrease inversely with the increase of the ascites or the tumors. In the incipient period of tumor transplantation, the level rather
Orita, Kunzo
core   +1 more source

Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation

Frontiers in Immunology, 2020
The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation.
Jin Y. Chen, Neeti S. Galwankar, Heather N. Emch, Smrithi S. Menon, Claudio Cortes, Joshua M. Thurman, Samuel A. Merrill, Robert A. Brodsky, Viviana P. Ferreira   +8 more
doaj   +1 more source

Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection [PDF]

, 2017
[Abstract] Background. Heart transplantation (HT) is a life-saving treatment for patients with end-stage heart failure. One of the main problems after HT is the humoral response termed antibody-mediated rejection (AMR).
Barge-Caballero, Eduardo, Cid, Javier, Crespo-Leiro, María Generosa, Grille Cancela, Zulaika, Hermida-Prieto, Manuel, Marrón Liñares, Grecia Manuela, Muñiz, Javier, Núñez, Lucía, Paniagua-Martín, María J., Pombo-Otero, Jorge, Rene Rodríguez, E., Suárez-Fuentetaja, Natalia, Tan, Carmela D., Vázquez Rodríguez, José Manuel   +13 more
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HBSP improves kidney ischemia-reperfusion injury and promotes repair in properdin deficient mice via enhancing phagocytosis of tubular epithelial cells

Frontiers in Immunology, 2023
Phagocytosis plays vital roles in injury and repair, while its regulation by properdin and innate repair receptor, a heterodimer receptor of erythropoietin receptor (EPOR)/β common receptor (βcR), in renal ischaemia-reperfusion (IR) remains unclear ...
Yuanyuan Wu, Yuanyuan Wu, Lili Huang, Wenli Sai, Fei Chen, Yu Liu, Cheng Han, Joanna M. Barker, Zinah D. Zwaini, Mark P. Lowe, Nigel J. Brunskill, Nigel J. Brunskill, Bin Yang, Bin Yang   +13 more
doaj   +1 more source

A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples.

PLoS ONE, 2014
The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. Dysregulation of complement can promote
Diana Pauly, Benedikt M Nagel, Jörg Reinders, Tobias Killian, Matthias Wulf, Susanne Ackermann, Boris Ehrenstein, Peter F Zipfel, Christine Skerka, Bernhard H F Weber   +9 more
doaj   +1 more source

Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator [PDF]

, 2017
Background Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The polymorphism rs10490924 in the ARMS2 gene is highly associated with AMD and linked to an indel mutation (del443ins54), the latter inducing ...
Jacob, Saskia, Joussen, Antonia M. [u. v. m.], Lin, Yuchen, Micklisch, Sven   +3 more
core   +1 more source

Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease [PDF]

, 2011
Background Complement proteins and activation products have been found associated with neuropathology in Alzheimer's disease (AD). Recently, a C5a receptor antagonist was shown to suppress neuropathology in two murine models of AD, Tg2576 and
Maria I Fonseca, Shu-Hui Chu, Alisia M Berci, Marie E Benoit, Douglas G Peters, Yuko Kimura, Andrea J Tenner   +6 more
core   +2 more sources