Results 21 to 30 of about 6,251 (169)

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease. [PDF]

Am J Hematol
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Allali S, Sbeih N, Rignault-Bricard R, Bruce J, Gall ML, Heilbronner C, de Cacqueray N, Angyalosy S, Taylor M, Brice J, de Montalembert M, Bevacqua M, Gautier EF, Hermine O, Maciel TT.   +14 more
europepmc   +2 more sources

A novel assay that characterizes properdin function shows neutrophil-derived properdin has a distinct oligomeric distribution

Frontiers in Immunology, 2023
Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore, Smrithi S. Menon, Neeti S. Galwankar, Sadik A. Khuder, Michael K. Pangburn, Viviana P. Ferreira   +5 more
doaj   +1 more source

The Complement System in ANCA-Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs. [PDF]

Immun Inflamm Dis
Complement activation, particularly via the alternative pathway, drives inflammation and organ damage in ANCA‐associated vasculitis. This review highlights mechanistic insights, tissue and biomarker evidence, and clinical implications of targeting the C5a–C5aR1 axis.
Sunmboye K, Millan P.
europepmc   +2 more sources

Infiltrating myeloid cell-derived properdin markedly promotes microglia-mediated neuroinflammation after ischemic stroke

Journal of Neuroinflammation, 2023
Background Emerging evidence has shown that myeloid cells that infiltrate into the peri-infarct region may influence the progression of ischemic stroke by interacting with microglia.
Pin-yi Liu, Hui-qin Li, Meng-qi Dong, Xin-ya Gu, Si-yi Xu, Sheng-nan Xia, Xin-yu Bao, Yun Xu, Xiang Cao   +8 more
doaj   +1 more source

Properdin oligomers adopt rigid extended conformations supporting function

eLife, 2021
Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure links
Dennis V Pedersen, Martin Nors Pedersen, Sofia MM Mazarakis, Yong Wang, Kresten Lindorff-Larsen, Lise Arleth, Gregers R Andersen   +6 more
doaj   +1 more source

Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus Infection

Frontiers in Immunology, 2021
The complement system is designed to recognise and eliminate invading pathogens via activation of classical, alternative and lectin pathways. Human properdin stabilises the alternative pathway C3 convertase, resulting in an amplification loop that leads ...
Praveen M. Varghese, Praveen M. Varghese, Shuvechha Mukherjee, Futwan A. Al-Mohanna, Souad M. Saleh, Fahad N. Almajhdi, Nazar Beirag, Saad H. Alkahtani, Reena Rajkumari, Beatrice Nal Rogier, Robert B. Sim, Susan Idicula-Thomas, Taruna Madan, Valarmathy Murugaiah, Uday Kishore   +14 more
doaj   +1 more source

Complement and transplant-associated thrombotic microangiopathy: Current and future approaches. [PDF]

Hemasphere
HemaSphere, Volume 10, Issue 4, April 2026.
Cugno M, Onida F, Lämmle B.
europepmc   +2 more sources

Properdin Deficiency Impairs Phagocytosis and Enhances Injury at Kidney Repair Phase Post Ischemia–Reperfusion

Frontiers in Immunology, 2021
Properdin, a positive regulator of complement alternative pathway, participates in renal ischemia–reperfusion (IR) injury and also acts as a pattern-recognition molecule affecting apoptotic T-cell clearance.
Yuanyuan Wu, Yuanyuan Wu, Zinah D. Zwaini, Nigel J. Brunskill, Nigel J. Brunskill, Xinyue Zhang, Hui Wang, Ravinder Chana, Cordula M. Stover, Bin Yang, Bin Yang   +10 more
doaj   +1 more source

The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa

Frontiers in Immunology, 2020
Properdin (P) is a positive regulatory protein that stabilizes the C3 convertase and C5 convertase of the complement alternative pathway (AP). Several studies have suggested that properdin can bind directly to the surface of certain pathogens regardless ...
Adriana Patricia Granados Martinez, Patrícia Antonia Estima Abreu, Silvio de Arruda Vasconcellos, Paulo Lee Ho, Viviana P. Ferreira, Gurpanna Saggu, Angela Silva Barbosa, Lourdes Isaac   +7 more
doaj   +1 more source

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study. [PDF]

Clin Transl Sci
ABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Sandhu A, Shen T, Herrero PM, Yuan CX, Qureshi S, Jiang X, Sheng Y, Gasteyger C, Dai Y.   +8 more
europepmc   +2 more sources