Results 1 to 10 of about 748 (83)

Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. [PDF]

Journal of Experimental Medicine, 1977
The complement regulatory enzyme, C3b inactivator (C3bINA), has been purified from human serum by affinity chromatography on an anti-C3bINA Sepharose column. Subsequent chromatography on DEAE-cellulose and removal of IgG with anti-IgG Sepharose resulted in a product which was found to be homogeneous by polyacrylamide gel electrophoresis at pH 8.9 and ...
Robert D Schreiber
exaly   +3 more sources

Purification of the human complement control protein C3b inactivator [PDF]

Biochemical Journal, 1980
An alternative method of isolation from human plasma is described for C3b inactivator, C3bINA, the proteinase that in conjunction with either beta 1H or C4b-binding protein will hydrolyse respectively C3b or C4b, the activation products of the third, C3 and fourth, C4, components of complement. The purification is by chromatography of plasma on columns
L G, Crossley, R R, Porter
exaly   +3 more sources

Diversity of Sites for Measles Virus Binding and for Inactivation of Complement C3b and C4b on Membrane Cofactor Protein CD46 [PDF]

Journal of Biological Chemistry, 1995
The complement system membrane cofactor protein (MCP) CD46 serves as a C3b/C4b inactivating factor for the protection of host cells from autologous complement attack and as a receptor for measles virus (MV). MCP consists of four short consensus repeats (SCR) which are the predominant extracellular structural motif.
K, Iwata, T, Seya, Y, Yanagi, J M, Pesando, P M, Johnson, M, Okabe, S, Ueda, H, Ariga, S, Nagasawa   +8 more
openaire   +2 more sources

Mast cells and complement system: Ancient interactions between components of innate immunity

Allergy, Volume 75, Issue 11, Page 2818-2828, November 2020., 2020
Abstract The emergence and evolution of the complement system and mast cells (MCs) can be traced back to sea urchins and the ascidian Styela plicata, respectively. Acting as a cascade of enzymatic reactions, complement is activated through the classical (CP), the alternative (AP), and the lectin pathway (LP) based on the recognized molecules.
Daniel Elieh Ali Komi, Farzaneh Shafaghat, Petri T. Kovanen, Seppo Meri   +3 more
wiley   +1 more source

Downregulation of C3 and C4A/B complement factor fragments in plasma from patients with squamous cell carcinoma of the penis

International Brazilian Journal of Urology, 2012
Purpose To investigate the use of ClinProt technique to identify cancer markers in plasma of patients suffering from squamous cell carcinoma of the penis (SCCP). Materials and Methods Plasma of 36 healthy subjects and 25 patients with
Paulo Ornellas, Antonio Augusto Ornellas, Clizia Chinello, Erica Gianazza, Veronica Mainini, Marta Cazzaniga, Denise Abreu Pereira, Vanessa Sandim, Ana Sheila Cypriano, Leandro Koifman, Paulo Cesar Barbosa da Silva, Gilda Alves, Fulvio Magni   +12 more
doaj   +1 more source

Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age‐Related Macular Degeneration

Disease Markers, Volume 2019, Issue 1, 2019., 2019
Background. To determine the impact of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 genotypes on the development of age‐related macular degeneration (AMD) in the Lithuanian population. Methods. A total of 916 subjects were examined: 309 patients with early AMD, 301 patients with exudative AMD,
Rasa Liutkeviciene, Alvita Vilkeviciute, Greta Gedvilaite, Kriste Kaikaryte, Loresa Kriauciuniene, Taina K. Lajunen   +5 more
wiley   +1 more source

The Importance of C4d in Biopsies of Kidney Transplant Recipients

Journal of Immunology Research, Volume 2013, Issue 1, 2013., 2013
Antibody‐mediated rejection (AMR) is highly detrimental to the prolonged survival of transplanted kidneys. C4d has been regarded as a footprint of AMR tissue damage, and the introduction of C4d staining in daily clinical practice aroused an ever‐increasing interest in the role of antibody‐mediated mechanisms in allograft rejection.
Rosana Rosa Miranda Corrêa, Juliana Reis Machado, Marcos Vinícius da Silva, Fernanda Rodrigues Helmo, Camila Souza Oliveira Guimarães, Laura Penna Rocha, Ana Carolina Guimarães Faleiros, Marlene Antônia dos Reis, Aron Chakera   +8 more
wiley   +1 more source

Rheumatoid Factor, Complement, and Mixed Cryoglobulinemia

Journal of Immunology Research, Volume 2012, Issue 1, 2012., 2012
Low serum level of complement component 4 (C4) that occurs in mixed cryoglobulinemia (MC) may be due to in vivo or ex vivo activation of complement by the classical pathway. Potential activators include monoclonal IgM rheumatoid factor (RF), IgG antibodies, and the complexing of the two in the cold, perhaps modulated by the rheology and stoichiometry ...
Peter D. Gorevic, Domenico Sansonno
wiley   +1 more source

High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders

Autism Research and Treatment, Volume 2012, Issue 1, 2012., 2012
Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality. Immune system abnormalities may be caused partly by complement system factor I deficiency.
Naghi Momeni, Lars Brudin, Fatemeh Behnia, Berit Nordström, Ali Yosefi-Oudarji, Bengt Sivberg, Mohammad T. Joghataei, Bengt L. Persson, Judy Van de Water   +8 more
wiley   +1 more source

Inhibitors of Complement Activity in Human Breast‐Milk: A Proposed Hypothesis of Their Physiological Significance

Mediators of Inflammation, Volume 8, Issue 2, Page 69-75, 1999., 1999
Several natural components abundant in the fluid phase of human breast‐milk have been shown to be inhibitors of complement activation in vitro, particularly the classical pathway. These include lysozyme, lactoferrin, lactalbumin alpha and other ligand chelators, complement regulator proteins and other specific soluble inhibitors of complement ...
Michael Oladipo Ogundele
wiley   +1 more source