Results 11 to 20 of about 3,381 (120)

Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age‐Related Macular Degeneration

Disease Markers, Volume 2019, Issue 1, 2019., 2019
Background. To determine the impact of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 genotypes on the development of age‐related macular degeneration (AMD) in the Lithuanian population. Methods. A total of 916 subjects were examined: 309 patients with early AMD, 301 patients with exudative AMD,
Rasa Liutkeviciene, Alvita Vilkeviciute, Greta Gedvilaite, Kriste Kaikaryte, Loresa Kriauciuniene, Taina K. Lajunen   +5 more
wiley   +1 more source

The Importance of C4d in Biopsies of Kidney Transplant Recipients

Journal of Immunology Research, Volume 2013, Issue 1, 2013., 2013
Antibody‐mediated rejection (AMR) is highly detrimental to the prolonged survival of transplanted kidneys. C4d has been regarded as a footprint of AMR tissue damage, and the introduction of C4d staining in daily clinical practice aroused an ever‐increasing interest in the role of antibody‐mediated mechanisms in allograft rejection.
Rosana Rosa Miranda Corrêa, Juliana Reis Machado, Marcos Vinícius da Silva, Fernanda Rodrigues Helmo, Camila Souza Oliveira Guimarães, Laura Penna Rocha, Ana Carolina Guimarães Faleiros, Marlene Antônia dos Reis, Aron Chakera   +8 more
wiley   +1 more source

The interaction of C3b bound to pneumococci with factor H (beta 1H globulin), factor I (C3b/C4b inactivator), and properdin factor B of the human complement system.

Journal of Immunology, 1983
Pneumococcal cell walls are potent activators of the alternative complement (C) pathway; pneumococcal capsules are not. C3b that is deposited onto the cell walls of encapsulated organisms, however, functions inefficiently in host defense compared to C3b ...
E. Brown, K. Joiner, T. Gaither, C. Hammer, M. Frank   +4 more
semanticscholar   +1 more source

Rheumatoid Factor, Complement, and Mixed Cryoglobulinemia

Journal of Immunology Research, Volume 2012, Issue 1, 2012., 2012
Low serum level of complement component 4 (C4) that occurs in mixed cryoglobulinemia (MC) may be due to in vivo or ex vivo activation of complement by the classical pathway. Potential activators include monoclonal IgM rheumatoid factor (RF), IgG antibodies, and the complexing of the two in the cold, perhaps modulated by the rheology and stoichiometry ...
Peter D. Gorevic, Domenico Sansonno
wiley   +1 more source

High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders

Autism Research and Treatment, Volume 2012, Issue 1, 2012., 2012
Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality. Immune system abnormalities may be caused partly by complement system factor I deficiency.
Naghi Momeni, Lars Brudin, Fatemeh Behnia, Berit Nordström, Ali Yosefi-Oudarji, Bengt Sivberg, Mohammad T. Joghataei, Bengt L. Persson, Judy Van de Water   +8 more
wiley   +1 more source

Inhibitors of Complement Activity in Human Breast‐Milk: A Proposed Hypothesis of Their Physiological Significance

Mediators of Inflammation, Volume 8, Issue 2, Page 69-75, 1999., 1999
Several natural components abundant in the fluid phase of human breast‐milk have been shown to be inhibitors of complement activation in vitro, particularly the classical pathway. These include lysozyme, lactoferrin, lactalbumin alpha and other ligand chelators, complement regulator proteins and other specific soluble inhibitors of complement ...
Michael Oladipo Ogundele
wiley   +1 more source

Surface-associated heparin inhibits zymosan-induced activation of the human alternative complement pathway by augmenting the regulatory action of the control proteins on particle-bound C3b

Journal of Experimental Medicine, 1979
Discrimination by the human alternative pathway between activating and nonactivating particles occurs after deposition of C3b by the continuous low-grade interaction of the alternative pathway components in biologic fluids and is dependent on the ...
Michel D. Kazatchkine, Douglas T. Fearon, Jeremiah E. Silbert, And K Frank Austen   +3 more
semanticscholar   +1 more source

Activation of the Alternative Complement Pathway by Escherichia Coli: Resistance of Bound C3b to Inactivation by C3bINA and β1H

Journal of Immunology, 1978
The surfaces of activators of the alternative pathway, such as zymosan and rabbit erythrocytes, provide sites which protect bound C3b from inactivation by C3b inactivator (C3bINA) and β1H, and P,C3b,Bb from decay-dissociation by β1H.
D. Fearon
semanticscholar   +1 more source

Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes

Journal of Experimental Medicine, 1980
Short-term cultures of human peripheral blood monocytes were shown to synthesize the alternative pathway complement components C3, factors B (B) and D (D), and properdin, the regulatory proteins C3b inactivator (C3bINA) and beta 1H, in addition to C2, C4,
K. Whaley
semanticscholar   +1 more source

Activation of the alternative complement pathway with rabbit erythrocytes by circumvention of the regulatory action of endogenous control proteins

Journal of Experimental Medicine, 1977
Cleavage of C3 by the alternative complement pathway occurs in at least two distinct phases: continuous low grade generation of C3b by the interaction of native C3, B, D, and P, and subsequent amplified cleavage of C3 by the interaction of C3b, B, D, and
D. Fearon, K. Austen
semanticscholar   +1 more source