Staphylococcal protein Ecb impairs complement receptor-1 mediated recognition of opsonized bacteria. [PDF]
PLoS ONE, 2017 Staphyloccus aureus is a major human pathogen leading frequently to sepsis and soft tissue infections with abscesses. Multiple virulence factors including several immune modulating molecules contribute to its survival in the host. When S.
Hanne Amdahl +7 more
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Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b. [PDF]
PLoS ONE, 2012 Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Tina K Koch +7 more
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Molecular Simulation Study on the Interaction between Porcine CR1-like and C3b
Molecules, 2023 The molecular basis of porcine red blood cell immune adhesion function stems from the complement receptor type 1-like (CR1-like) on its cell membrane.
Zhen Hou, Na Sun, Hongquan Li
exaly +3 more sources
A novel and rapid method to purify the human complement opsonin C3b from human plasma [PDF]
Frontiers in ImmunologyComplement opsonin C3b is at the center of the complement cascade. All complement initiation pathways converge when convertases activate C3, converting it into the anaphylatoxin C3a and the opsonin C3b, which can attach to surfaces via its freshly ...
Jannik Sichau, Christoph Q. Schmidt
doaj +2 more sources
Autoantibodies Against C3b—Functional Consequences and Disease Relevance
Frontiers in Immunology, 2019 The complement component C3 is at the heart of the complement cascade. It is a complex protein, which generates different functional activated fragments (C3a, C3b, iC3b, C3c, C3d).
Vasil Vasilev +2 more
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Structural insights into C3 convertase activity of the classical pathway of complement [PDF]
Nature CommunicationsImmune protection by the complement system depends on C3 cleavage by C3 convertases that is critical to all three activation pathways. Structural data on convertase formation in the classical pathway and on C3-substrate binding to convertases is lacking.
Karla I. De la O Becerra +3 more
doaj +2 more sources
In vitro complement activation via nucleocapsid and spike proteins of SARS-CoV-2 in COVID-19 patients [PDF]
Scientific ReportsIn the overactivation of the complement, the role of classical pathway is still not thoroughly investigated in COVID-19. Our aim was to examine the connection between SARS-CoV-2-specific antibodies, in vitro complement activation, and in vivo complement ...
Petra Kiszel +5 more
doaj +2 more sources
Understanding ADHD: Toward an Innovative Therapeutic Intervention
Bioengineering, 2021 Attention deficit hyperactivity disorder (ADHD) is a pervasive condition affecting persons across all age groups, although it is primarily diagnosed in children.
Allyson Camp +7 more
doaj +1 more source
Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. [PDF]
PLoS ONE, 2016 Complement factor H-related protein 1 (CFHR1) is a complement regulator which has been reported to regulate complement by blocking C5 convertase activity and interfering with C5b surface association. CFHR1 also competes with complement factor H (CFH) for
Jonathan P Hannan +4 more
doaj +1 more source
Scientific Reports, 2023 The complement system provides vital immune protection against infectious agents by labeling them with complement fragments that enhance phagocytosis by immune cells.
Elena Boero +12 more
doaj +1 more source