Results 21 to 30 of about 37,904 (214)

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M, Kishore, U, Kouser, L, Nayak, A, Sim, RB, Stover, CM   +5 more
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Buoyancy regulation and aggregate formation in Amoebobacter purpureus from Mahoney lake [PDF]

, 1992
The meromictic Mahoney Lake (British Columbia, Canada) contains an extremely dense layer of purple sulfur bacteria (Amoebobacter purpureus). The buoyant density of Amoebobacter cells grown in pure culture at saturating light intensity was significantly ...
Bar-Ness, Bar-Or, Booker, Bryant, Bührer, Caldwell, Cline, Courtney, Dahlbäck, Dietrich, Doyle, Eichler, Fattom, Hart, Hartree, Herbert, Huheey, Hutchinson, Jenkinson, Jörg Overmann, Kjelleberg, Lehninger, Marshall, Mas, Nikovskaya, Norbert Pfennig, Northcote, Northcote, Northcote, Ofek, Oliver, Oliver, Overmann, Overmann, Overmann, Parker, Pfennig, Reed, Rosenberg, Siefert, Takakuwa, Tilzer, Walsby, Walsby   +43 more
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Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Frontiers in Immunology, 2019
Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the ...
Ramon M. van den Bos, Nicholas M. Pearce, Joke Granneman, T. Harma C. Brondijk, Piet Gros   +4 more
doaj   +1 more source

Methods of ex vivo analysis of tissue status in vascularized composite allografts

Journal of Translational Medicine, 2023
Vascularized composite allotransplantation can improve quality of life and restore functionality. However, the complex tissue composition of vascularized composite allografts (VCAs) presents unique clinical challenges that increase the likelihood of ...
Carolyn Ton, Sara Salehi, Sara Abasi, John R. Aggas, Renee Liu, Gerald Brandacher, Anthony Guiseppi-Elie, Warren L. Grayson   +7 more
doaj   +1 more source

CLONING OF THE 1.4-kb mRNA SPECIES OF HUMAN COMPLEMENT FACTOR H REVEALS A NOVEL MEMBER OF THE SHORT CONSENSUS REPEAT FAMILY RELATED TO THE CARBOXY TERMINAL OF THE CLASSICAL 150-kDa MOLECULE [PDF]

, 1991
Three factor H mRNA species of 4.3 kb, 1.8 kb, and 1.4 kb are constitutively expressed in human liver. Having previously characterized full-length cDNA clones derived from the 4.3-kb and 1.8-kb factor mRNA, we report here the isolation and eucaryotic ...
Dierich, Manfred P., Estaller, C., Koistinen, V., Schwaeble, W., Weiss, Elisabeth H.   +4 more
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Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

Frontiers in Immunology, 2022
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Ole-Lars Brekke, Ole-Lars Brekke   +14 more
doaj   +1 more source

Toward a hemorrhagic trauma severity score: fusing five physiological biomarkers

Journal of Translational Medicine, 2020
Background To introduce the Hemorrhage Intensive Severity and Survivability (HISS) score, based on the fusion of multi-biomarker data; glucose, lactate, pH, potassium, and oxygen tension, to serve as a patient-specific attribute in hemorrhagic trauma ...
Ankita Bhat, Daria Podstawczyk, Brandon K. Walther, John R. Aggas, David Machado-Aranda, Kevin R. Ward, Anthony Guiseppi-Elie   +6 more
doaj   +1 more source

Insights Into the Structure-Function Relationships of Dimeric C3d Fragments

Frontiers in Immunology, 2021
Cleavage of C3 to C3a and C3b plays a central role in the generation of complement-mediated defences. Although the thioester-mediated surface deposition of C3b has been well-studied, fluid phase dimers of C3 fragments remain largely unexplored.
Ayla A. Wahid, Rhys W. Dunphy, Alex Macpherson, Alex Macpherson, Beth G. Gibson, Liudmila Kulik, Kevin Whale, Catherine Back, Thomas M. Hallam, Bayan Alkhawaja, Rebecca L. Martin, Ingrid Meschede, Maisem Laabei, Alastair D. G. Lawson, V. Michael Holers, Andrew G. Watts, Andrew G. Watts, Susan J. Crennell, Claire L. Harris, Kevin J. Marchbank, Jean M. H. van den Elsen, Jean M. H. van den Elsen   +21 more
doaj   +1 more source

Human complement factor H [PDF]

, 1986
We isolated cDNA clones coding for the functionally important tryptic N-terminal38- kDa fragment of human complement control protein factor H using polyclonal and monoclonal antibodies to screen a human liver cDNA library cloned in a bacterial expression
Dierich, Manfred P., Schulz, T. F., Schwaeble, W., Stanley, K. K., Weiss, Elisabeth H.   +4 more
core   +1 more source

The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct Binding to the Proconvertase C3b-B

Frontiers in Immunology, 2017
Saliva of the blood feeding sand fly Lutzomyia longipalpis was previously shown to inhibit the alternative pathway (AP) of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP.
Antonio F. Mendes-Sousa, Antonio F. Mendes-Sousa, Vladimir Fazito do Vale, Vladimir Fazito do Vale, Naylene C. S. Silva, Anderson B. Guimaraes-Costa, Marcos H. Pereira, Marcos H. Pereira, Mauricio R. V. Sant’Anna, Mauricio R. V. Sant’Anna, Fabiano Oliveira, Shaden Kamhawi, José M. C. Ribeiro, John F. Andersen, Jesus G. Valenzuela, Ricardo N. Araujo, Ricardo N. Araujo   +16 more
doaj   +1 more source