Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase. [PDF]
The Journal of experimental medicine, 1975 A function of P in the alternative complement pathway is to prolong the first order decay of the hemolytic sites on EAC43B in a dose-dependent manner. As the number of initial convertase sites is not changed, even when activated properdin (P) increases the t1/2 10-fold or more, P acts to stabilize rather than to uncover additional sites.
D T, Fearon, K F, Austen
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Trends in Ocean S‐Isotopes May Be Influenced by Major LIP Events
Geophysical Monograph Series, Page 341-376., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Ross. R. Large +5 more
wiley +1 more source
Frontiers in Immunology, 2022 The complement system is a part of the innate immune system, where it labels intruding pathogens as well as dying host cells for clearance. If complement regulation is compromised, the system may contribute to pathogenesis.
Henrik Pedersen +7 more
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Accelerated decay of C3b to iC3b when C3b is bound to the Cryptococcus neoformans capsule [PDF]
Infection and Immunity, 1993 Incubation of encapsulated and nonencapsulated Cryptococcus neoformans in normal human serum (NHS) leads to activation and binding of potentially opsonic fragments of complement component C3 to the yeast cells. Analysis of the molecular forms of C3 after incubation of encapsulated cryptococci in NHS showed that the percentage of bound C3 occurring as ...
G S, Pfrommer +4 more
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Bioengineering, 2014 The dual responsive Electrochemical Cell-on-a-Chip Microdisc Electrode Array (ECC MDEA 5037) is a recently developed electrochemical transducer for use in a wireless, implantable biosensor system for the continuous measurement of interstitial glucose and
Christian N. Kotanen +2 more
doaj +1 more source
Characterization of Binding Properties of Individual Functional Sites of Human Complement Factor H
Frontiers in Immunology, 2020 Factor H exists as a 155,000 dalton, extended protein composed of twenty small domains which is flexible enough that it folds back on itself. Factor H regulates complement activation through its interactions with C3b and polyanions.
Aftabul Haque +7 more
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Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]
, 2019 Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Atkinson, John P +11 more
core +3 more sources
Biomolecules, 2022 Uncontrolled complement activation contributes to multiple immune pathologies. Although synthetic compstatin derivatives targeting C3 and C3b are robust inhibitors of complement activation, their physicochemical and molecular properties may limit access ...
Joshua Garlich +7 more
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Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode [PDF]
, 2016 Item does not contain ...
Atkinson, John P +14 more
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Microfabricated and 3-D Printed Soft Bioelectronic Constructs from PAn-PAAMPSA-Containing Hydrogels
Bioengineering, 2018 The formation of hybrid bioactive and inherently conductive constructs of composites formed from polyaniline-polyacrylamidomethylpropane sulfonic acid (PAn-PAAMPSA) nanomaterials (0.00–10.0 wt%) within poly(2-hydroxy ethyl methacrylate-co-N-{Tris ...
John R. Aggas +5 more
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