Results 41 to 50 of about 113,435 (208)

Relevance of G protein‐coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation

British Journal of Pharmacology, Volume 182, Issue 14, Page 3211-3224, July 2025.
Abstract G protein‐coupled receptors (GPCRs) are one of the major drug targets. In recent years, computational drug design for GPCRs has mainly focused on static structures obtained through X‐ray crystallography, cryogenic electron microscopy (cryo‐EM) or in silico modelling as a starting point for virtual screening campaigns. However, GPCRs are highly
Marta Lopez‐Balastegui, Tomasz Maciej Stepniewski, Małgorzata M. Kogut‐Günthel, Antonella Di Pizio, Mette Marie Rosenkilde, Jiafei Mao, Jana Selent   +6 more
wiley   +1 more source

Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease? [PDF]

, 2011
Background Anorexia nervosa carries the highest mortality rate of any psychiatric disorder. Even the most critically ill anorexic patients may present with normal 'standard' laboratory values, underscoring the need for a new sensitive ...
Michael A Flierl, Jennifer L Gaudiani, Allison L Sabel, Carlin S Long, Philip F Stahel, Philip S Mehler   +5 more
core   +1 more source

Lung‐Specific mRNA Delivery by Ionizable Lipids with Defined Structure‐Function Relationship and Unique Protein Corona Feature

Advanced Science, Volume 12, Issue 14, April 10, 2025.
A novel structure‐function relationship is identified for lung‐targeting ionizable lipids with nonpermanent charges. These lipids feature N‐methyl and secondary amine groups in their heads and three tails derived from epoxyalkanes, demonstrating superior pulmonary selectivity and efficiency.
Xiaoyan He, Runyuan Wang, Yan Cao, Yan Ding, Yan Chang, Haoru Dong, Rong Xie, Guisheng Zhong, Huiying Yang, Jianfeng Li   +9 more
wiley   +1 more source

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

Baculovirus GP64-pseudotyped HIV-based lentivirus vectors are stabilized against complement inactivation by codisplay of decay accelerating factor (DAF) or of a GP64–DAF fusion protein

Molecular Therapy, 2005
The eventual development of efficient gene transfer vectors for in vivo gene delivery will require the development of a number of important new technologies such as stabilization of vectors against protective mechanisms that destroy or otherwise inactivate foreign infectious agents like gene transfer vectors.
Guibinga, Ghiabe H., Friedmann, Theodore
openaire   +2 more sources

ARHGAP29 promotes keratinocyte proliferation and migration in vitro and is dispensable for in vivo wound healing

Developmental Dynamics, Volume 254, Issue 4, Page 310-329, April 2025.
Abstract Background RhoA GTPases play critical roles in actin cytoskeletal remodeling required for controlling a diverse range of cellular functions including cell proliferation, adhesion, migration and changes in cell shape, all required for cutaneous wound healing.
Lindsey Rhea, Tanner Reeb, Emily Adelizzi, Bailey Garnica, Allison Stein, Alexis Kollash, Elliot Dunnwald, Martine Dunnwald   +7 more
wiley   +1 more source

Identification and characterization of DICER‐LIKE genes and their roles in Marchantia polymorpha development and salt stress response

The Plant Journal, Volume 121, Issue 3, February 2025.
SUMMARY DICER‐LIKE (DCL) proteins play a central role in plant small RNA (sRNA) biogenesis. The genome of the early land plant Marchantia polymorpha encodes four DCL proteins: MpDCL1a, MpDCL1b, MpDCL3, and MpDCL4. While MpDCL1a, MpDCL3 and MpDCL4 show high similarities to their orthologs in Physcomitrium patens and Arabidopsis thaliana, MpDCL1b shares ...
Erika Csicsely, Anja Oberender, Anastasia‐Styliani Georgiadou, Johanna Alz, Sebastian Kiel, Nora Gutsche, Sabine Zachgo, Jennifer Grünert, Andreas Klingl, Oguz Top, Wolfgang Frank   +10 more
wiley   +1 more source

The moulting arthropod: a complete genetic toolkit review

Biological Reviews, Volume 99, Issue 6, Page 2338-2375, December 2024.
ABSTRACT Exoskeletons are a defining character of all arthropods that provide physical support for their segmented bodies and appendages as well as protection from the environment and predation. This ubiquitous yet evolutionarily variable feature has been instrumental in facilitating the adoption of a variety of lifestyles and the exploitation of ...
Giulia Campli, Olga Volovych, Kenneth Kim, Werner P. Veldsman, Harriet B. Drage, Idan Sheizaf, Sinéad Lynch, Ariel D. Chipman, Allison C. Daley, Marc Robinson‐Rechavi, Robert M. Waterhouse   +10 more
wiley   +1 more source

Sex differences on constitutive long non‐coding RNA expression: Modulatory effect of estradiol and testosterone in muscle cells

Andrology, Volume 12, Issue 8, Page 1887-1896, November 2024.
Abstract Introduction Despite the growing awareness of sexual dimorphism between males and females under pathological and physiological conditions, sex bias in biomedical research in animal models and patients is still present nowadays. The main objective of this work was to investigate sex differences in constitutive long non‐coding RNA expression in ...
Tresa López‐Royo, Laura Moreno‐Martínez, Leticia Moreno‐García, Ana Cristina Calvo, Raquel Manzano, Rosario Osta   +5 more
wiley   +1 more source

Fluorescent Reporters, Imaging, and Artificial Intelligence Toolkits to Monitor and Quantify Autophagy, Heterophagy, and Lysosomal Trafficking Fluxes

Traffic, Volume 25, Issue 10, October 2024.
Our review reports on qualitative, quantitative, and chronological monitoring of lysosomal protein trafficking, and of autophagic and heterophagic fluxes to acidic, degradative endolysosomes. We provide an up‐to‐date description of available single‐ and tandem‐fluorescent reporters, mono‐ and multi‐modal microscopy techniques, and artificial ...
Mikhail Rudinskiy, Diego Morone, Maurizio Molinari   +2 more
wiley   +1 more source