Results 51 to 60 of about 1,697 (143)

Protein tyrosine phosphatase 1B (PTP1B) function, structure, and inhibition strategies to develop antidiabetic drugs

FEBS Letters, Volume 598, Issue 15, Page 1811-1838, August 2024.
This Review presents the main advances in the study of PTP1B since it was first isolated, and recent contextual information related to this protein. Furthermore, we provide an overview of the role of PTP1B in diabetes and obesity, and the challenges of developing selective, effective, potent, bioavailable, and cell‐permeable compounds that can inhibit ...
Andrea Coronell‐Tovar, Juan P. Pardo, Adela Rodríguez‐Romero, Alejandro Sosa‐Peinado, Luz Vásquez‐Bochm, Patricia Cano‐Sánchez, Laura Iliana Álvarez‐Añorve, Martin González‐Andrade   +7 more
wiley   +1 more source

[Anticomplement activity of a polyanion: pentosan sulfuric polyester. III. Mechanism of functional inactivation of the different properdin and complement system fractions] [PDF]

, 1977
International audienceIn vitro, the drug pentosan-poly-sulfoester (PPS) changes the electrophoretic migration of different proteins from the complement and properdin systems, such as native C3 (beta 1C globulin), C3c (beta-1A globulin), C3d (alpha-2D ...
Traeger, J., Berthoux, Fc, Freyria, Am
core  

Enhancing the revelation of key genes and interaction networks in non‐small cell lung cancer with major depressive disorder: A bioinformatics analysis

Health Science Reports, Volume 7, Issue 6, June 2024.
Abstract Background and Aims Lung cancer is ranked as the second most prevalent form of cancer worldwide. Nonsmall cell lung cancer (NSCLC) represents the predominant histological subtype. Research suggests that one‐third of lung cancer patients also experiencing depression. Antidepressants play an indispensable role in the management of NSCLC. Despite
Huan Gui, Xulong Chen, Yingjie Nie, Xiangyan Zhang   +3 more
wiley   +1 more source

Proteomic profiling of mesenchymal stem cell‐derived extracellular vesicles: Impact of isolation methods on protein cargo

Journal of Extracellular Biology, Volume 3, Issue 6, June 2024.
Abstract Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are secreted by cells and play a critical role in cell‐to‐cell communication. Despite the promising reports regarding their diagnostic and therapeutic potential, the utilization of EVs in the clinical setting is limited due to insufficient information about their ...
Morteza Abyadeh, Shahab Mirshahvaladi, Sara Assar Kashani, Joao A. Paulo, Ardeshir Amirkhani, Fatemeh Mehryab, Homeyra Seydi, Niloufar Moradpour, Sheyda Jodeiryjabarzade, Mehdi Mirzaei, Vivek Gupta, Faezeh Shekari, Ghasem Hosseini Salekdeh   +12 more
wiley   +1 more source

Polyhalogenated Carbohydrates: Synthesis and Applications of Sugar Halides from Fluorine to Iodine

European Journal of Organic Chemistry, Volume 27, Issue 16, April 22, 2024.
The societal importance of sucralose (a trichlorinated disaccharide) doesn't fade over time. This review focuses on the synthesis and applications of polyhalogenated carbohydrates incorporating fluorine, chlorine, bromine, and iodine atoms. An overview of the current state of the art of sugar inter‐halides is also presented.
Olivier Lessard, Danny Lainé, Denis Giguère   +2 more
wiley   +1 more source

The molecular characterisation of Group A Streptococcus among children with phyryngitis in the Vanguard community (Bonteheuwel [PDF]

, 2012
Includes abstract.
Muhamed, Babu
core  

Human complement factor H [PDF]

, 1991
Estaller, C., Schwaeble, W., Barbieri, A., Molgg, M., Feifel, E., Koistinen, V., Dierich, Manfred P., Weiss, Elisabeth H.   +7 more
core   +1 more source

The role of hypoxia and complement receptor 2 or toll-like receptor 2 on B1 B cell effector function [PDF]

Master of ScienceDivision of BiologySherry D. FlemingProfessional phagocytes play a critical role in maintaining homeostasis within a host through phagocytic, microbicidal, and inflammatory activity.
Knights, Kaori
core   +1 more source

Author Correction: Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties (Scientific Reports, (2017), 7, 1, (303), 10.1038/s41598-017-00412-4)

Scientific reports, 2019
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Röttgerding, Florian, Wagemakers, Alex, Koetsveld, Joris, Fingerle, Volker, Kirschfink, Michael, Hovius, Joppe W., Zipfel, Peter F., Wallich, Reinhard, Kraiczy, Peter   +8 more
openaire   +1 more source

Decoding the Factor H-Related Proteins: Gatekeepers of Complement Dysregulation in AMD. [PDF]

Eur J Immunol
Tang J, Zgoda N, Clark SJ.
europepmc   +1 more source