Results 51 to 60 of about 113,435 (208)

Protein tyrosine phosphatase 1B (PTP1B) function, structure, and inhibition strategies to develop antidiabetic drugs

FEBS Letters, Volume 598, Issue 15, Page 1811-1838, August 2024.
This Review presents the main advances in the study of PTP1B since it was first isolated, and recent contextual information related to this protein. Furthermore, we provide an overview of the role of PTP1B in diabetes and obesity, and the challenges of developing selective, effective, potent, bioavailable, and cell‐permeable compounds that can inhibit ...
Andrea Coronell‐Tovar, Juan P. Pardo, Adela Rodríguez‐Romero, Alejandro Sosa‐Peinado, Luz Vásquez‐Bochm, Patricia Cano‐Sánchez, Laura Iliana Álvarez‐Añorve, Martin González‐Andrade   +7 more
wiley   +1 more source

Lysis of measles virus-infected cells by the purified cytolytic alternative complement pathway and antibody

Journal of Experimental Medicine, 1979
The dependence of antibody-and-complement-mediated lysis of virus- infected cells on the alternative pathway was examined utilizing the isolated cytolytic alternative pathway--a system consisting of the six purified proteins of the alternative pathway of
J. Sissons, Robert D. Schreiber, Luc Perrin, Neil R. Cooper, H. Müller-Eberhard, M. B. Oldstone   +5 more
semanticscholar   +1 more source

Functional properties of membrane-associated complement receptor CR1.

Journal of Immunology, 1983
It was previously shown that membrane receptors for C3b (CR1) purified from human erythrocytes were powerful inhibitors of the complement cascade and that they encompass the regulatory functions of the serum proteins beta 1H (H) and C4-binding protein ...
K. Iida, V. Nussenzweig
semanticscholar   +1 more source

Enhancing the revelation of key genes and interaction networks in non‐small cell lung cancer with major depressive disorder: A bioinformatics analysis

Health Science Reports, Volume 7, Issue 6, June 2024.
Abstract Background and Aims Lung cancer is ranked as the second most prevalent form of cancer worldwide. Nonsmall cell lung cancer (NSCLC) represents the predominant histological subtype. Research suggests that one‐third of lung cancer patients also experiencing depression. Antidepressants play an indispensable role in the management of NSCLC. Despite
Huan Gui, Xulong Chen, Yingjie Nie, Xiangyan Zhang   +3 more
wiley   +1 more source

Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium [PDF]

, 2008
This study was prompted by the observation that decidual endothelial cells (DECs), unlike endothelial cells (ECs) of blood vessels in normal skin, kidney glomeruli and brain, express surface-bound C1q in physiologic pregnancy. This finding was unexpected,
Agostinis, C., Bossi, F., Bulla, R., De Seta, F., Debeus, A., Ghebrehiwet, B., Radillo, O., Rizzi, L., Tedesco, F., TRIPODO, Claudio   +9 more
core   +1 more source

Proteomic profiling of mesenchymal stem cell‐derived extracellular vesicles: Impact of isolation methods on protein cargo

Journal of Extracellular Biology, Volume 3, Issue 6, June 2024.
Abstract Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are secreted by cells and play a critical role in cell‐to‐cell communication. Despite the promising reports regarding their diagnostic and therapeutic potential, the utilization of EVs in the clinical setting is limited due to insufficient information about their ...
Morteza Abyadeh, Shahab Mirshahvaladi, Sara Assar Kashani, Joao A. Paulo, Ardeshir Amirkhani, Fatemeh Mehryab, Homeyra Seydi, Niloufar Moradpour, Sheyda Jodeiryjabarzade, Mehdi Mirzaei, Vivek Gupta, Faezeh Shekari, Ghasem Hosseini Salekdeh   +12 more
wiley   +1 more source

Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes [PDF]

, 2017
C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular hemolysis ...
A Hill, A Hill, A Nicholson-Weller, A Roth, AM Risitano, AM Risitano, AM Risitano, AM Risitano, AM Risitano, Antonio M. Risitano, B Nilsson, CE Schoot van der, DJ Araten, DS Holt, E Lach-Trifilieff, E Marchiafava, G Gronowicz, GL Logue, GV Seaman, J Nishimura, J Takeda, JD Tamerius, JE May, JP Atkinson, JV Dacie, L Luzzatto, L Luzzatto, L Luzzatto, M Bessler, M Harboe, M Kono, M Loschi, M Sica, M Sica, MA Lindorfer, Maria De Angioletti, MH Holguin, Michela Sica, MJ Harder, MK Pangburn, MK Pangburn, P Hillmen, P Hillmen, P Hillmen, Patrizia Ricci, PJ Lachmann, PJ Lachmann, RJ Kelly, RL Sparrow, Rosario Notaro, RP Latour de, RP Rother, S Berentsen, SK Krishnan, T Olutogun, T Rondelli, TH Ham, Tommaso Rondelli, UM Reiss, VM Holers, VP Ferreira, WF Rosse, WF Rosse, Z Fishelson, Z Lin   +64 more
core   +2 more sources

Polyhalogenated Carbohydrates: Synthesis and Applications of Sugar Halides from Fluorine to Iodine

European Journal of Organic Chemistry, Volume 27, Issue 16, April 22, 2024.
The societal importance of sucralose (a trichlorinated disaccharide) doesn't fade over time. This review focuses on the synthesis and applications of polyhalogenated carbohydrates incorporating fluorine, chlorine, bromine, and iodine atoms. An overview of the current state of the art of sugar inter‐halides is also presented.
Olivier Lessard, Danny Lainé, Denis Giguère   +2 more
wiley   +1 more source

Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex [PDF]

, 2016
Introduction Coagulation and complement systems are simultaneously activated at sites of tissue injury, leading to thrombin generation and opsonisation with C3b.
Baerga-Ortiz, Bajzar, Boehme, Bossi, Campbell, Conway, de Córdoba S, Delvaeye, Dragon-Durey, Esmon, Esmon, Esmon, Esparza-Gordillo, Faust, Fuentes-Prior, Gordon, Hakobyan, Hamad, Harris, Heurich, Hindmarsh, Honda, Huntington, Ikeda, Ito, Jokiranta, Kavanagh, Li, Light, Maga, Markiewski, Martinez-Barricarte, Mayer, Meri, Mizuno, Moll, Morgan, Mouksassi, Noris, Owen, Pangburn, Sadler, Sadler, Saito, Salem, Sawada, Schramm, Shental-Bechor, Suzuki, Tateishi, Tortajada, Udagawa, Vincent, Walport, Walport, Wu, Yada, Yamamoto, Zushi   +58 more
core   +2 more sources

Biomolecular Corona of Gold Nanoparticles: The Urgent Need for Strong Roots to Grow Strong Branches

Small, Volume 20, Issue 15, April 11, 2024.
This review presents a critical analysis of the current methodologies to decipher bio‐nano interactions by analyzing the biomolecular corona using gold nanoparticles as a case study. The study aims for a collective effort of the nano‐community through standardization of methodologies (for synthesis, characterization, and omics), data sharing, and ...
Luca Boselli, Valentina Castagnola, Andrea Armirotti, Fabio Benfenati, Pier Paolo Pompa   +4 more
wiley   +1 more source