Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections. [PDF]
Curr Opin Immunol, 2021 Membrane cofactor protein (MCP; CD46), a ubiquitously expressed complement regulatory protein, serves as a cofactor for serine protease factor I to cleave and inactivate C3b and C4b deposited on host cells. However, CD46 also plays roles in human reproduction, autophagy, modulating T cell activation and effector functions and is a member of the newly ...
Liszewski MK, Atkinson JP.
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Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs [PDF]
Journal of Neuroinflammation, 2004 Background Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This
McGeer Patrick L +2 more
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CD46 (membrane cofactor protein) associates with multiple β1 integrins and tetraspans [PDF]
European Journal of Immunology, 2000 The tetraspans associate with a large number of surface molecules, including a subset of beta1 integrins and, indirectly through CD19, with the complement receptor CD21. To further characterize the tetraspan complexes we have raised and selected monoclonal antibodies (mAb) for their ability to immunoprecipitate a molecule associated with CD9.
Stéphanie Lozahic +6 more
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Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies. [PDF]
PLoS ONE, 2015 Preeclampsia is a common disorder of pregnancy characterized by endothelial dysfunction. It may be life-threatening for the mother and fetus in severe cases.
A Inkeri Lokki +4 more
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Membrane cofactor protein (MCP; CD46) expression in transgenic mice [PDF]
Clinical and Experimental Immunology, 2001 SUMMARYHuman membrane cofactor protein (MCP; CD46) is a widely distributed complement regulator. In the mouse, expression of MCP is largely restricted to the testis while a related, widely expressed protein (Crry) appears to perform MCP's (CD46) regulatory activity.
Roberto Cattaneo +2 more
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Protective effect of membrane cofactor protein against complement-dependent injury [PDF]
Acta Pharmacologica Sinica, 2005 To evaluate the protective role of membrane cofactor protein (MCP, CD46) on complement-dependent injury.MCP was separated by ion exchange chromatography on a DEAE sephadex A-50 column from pig erythrocyte ghosts. Its protective effect was tested in models such as cobra venom factor (CVF)-induced platelet metamorphosis and aggregation, human serum ...
Dong Xu +3 more
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Membrane Cofactor Protein (MCP; CD46): Isoform-Specific Tyrosine Phosphorylation [PDF]
The Journal of Immunology, 2000 Abstract Membrane cofactor protein (MCP; CD46) is a widely expressed type 1 transmembrane glycoprotein that inhibits complement activation on host cells. It also is a receptor for several pathogens including measles virus, Streptococcus pyogenes, Neisseria gonorrhea, and Neisseria meningitidis.
Guixian Wang +3 more
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Identification of the Streptococcal M Protein Binding Site on Membrane Cofactor Protein (CD46) [PDF]
The Journal of Immunology, 2002 Abstract Adherence of group A streptococcus (GAS) to keratinocytes is mediated by an interaction between human CD46 (membrane cofactor protein) with streptococcal cell surface M protein. CD46 belongs to a family of proteins that contain structurally related short consensus repeat (SCR) domains and regulate the activation of the ...
Eleni Giannakis +9 more
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Bioinformatic analysis of the membrane cofactor protein CD46 and microRNA expression in hepatocellular carcinoma. [PDF]
Oncol Rep, 2014 Lu Z +10 more
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Biochemical characterization of membrane cofactor protein of the complement system. [PDF]
The Journal of Immunology, 1988 Abstract Membrane cofactor protein (MCP; formerly termed glycoprotein 45-70 to indicate its Mr) of complement is a widely distributed iC3/C3b binding protein with co-factor activity. On human mononuclear cells and cell lines and platelets, MCP is a doublet.
L L Ballard +3 more
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