Characterization of CR1- and membrane cofactor protein-like proteins of two primates. [PDF]
The Journal of Immunology, 1990 Abstract We have identified and characterized C3b binding proteins of two primates, orangutan (Pongo pygmaeus) and gorilla (Gorilla gorilla). Detergent solubilized 125I surface-labeled E and PBMC were subjected to affinity chromatography with homologous or human iC3/C3b. These ligands bound a 225,000 single chain protein from orangutan E
M W Nickells, John Atkinson
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Membrane Cofactor Protein (CD46) Is a Basolateral Protein That Is Not Endocytosed [PDF]
Journal of Biological Chemistry, 1997 Andrea Maisner +5 more
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Expression and characterization of CD46, membrane cofactor protein, in human colonic mucosa.
Japanese Journal of Clinical Immunology, 1996 CD 46, membrane cofactor protein (MCP), is a membrane regulatory glycoprotein of the complement system, and acts as a cofactor of factor I, which inactivates C3b and C4b bound on autologous cell membrane. MCP is present on human peripheral blood cells except erythrocytes, fibroblasts, epithelial and endothelial cells, and has been proved to exist in ...
Sadanobu Nakanishi +10 more
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PfVPS4, an ESCRT AAA-ATPase, is essential for asexual proliferation and gametocyte sexual conversion in Plasmodium falciparum [PDF]
Parasites & VectorsBackground Malaria, caused by Plasmodium spp., remains a major global health threat. Among them, Plasmodium falciparum is the most pathogenic, and its asexual intraerythrocytic proliferation is the pathological basis.
Wenyu Yang +5 more
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Transforming growth factor-β isoforms regulate the surface expression on membrane cofactor protein (CD46) and CD59 on human keratinocytes [PDF]
European Journal of Immunology, 1999 S S Asghar, J D Bos
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Distribution of membrane cofactor protein (MCP/CD46) on pig tissues. Relevance to xenotransplantation [PDF]
Immunology, 1999 Membrane cofactor protein (MCP; CD46) is a 50–60 000 MW glycoprotein, expressed on a wide variety of cells and tissues in man, which plays an important role in regulating complement activation. Human MCP has also been shown to be the receptor for measles virus.
Pérez De La Lastra +2 more
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Atypical Hemolytic Uremic Syndrome Triggered by Acute Pancreatitis in a Patient with a Membrane Cofactor Protein (CD46) Genetic Variant. [PDF]
Intern MedMochizuki K +8 more
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Correction: Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies. [PDF]
PLoS ONE, 2015 PLOS ONE Staff
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Microbial Protein Binding to gC1qR Drives PLA2G1B-Induced CD4 T-Cell Anergy
Frontiers in Immunology, 2022 The origin of the impaired CD4 T-cell response and immunodeficiency of HIV-infected patients is still only partially understood. We recently demonstrated that PLA2G1B phospholipase synergizes with the HIV gp41 envelope protein in HIV viremic plasma to ...
Julien Pothlichet +11 more
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Functional properties of membrane cofactor protein of complement [PDF]
Biochemical Journal, 1989 Membrane cofactor protein (MCP or gp45-70) of the complement system is a cofactor for factor I-mediated cleavage of fluid-phase C3b and C3b-like C3, which opens the thioester bond. In the present study the activity of MCP was further characterized. Unexpectedly, in the absence of factor I, MCP stabilized the alternative- and, to a lesser extent, the ...
T, Seya, J P, Atkinson
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