The multiverse of CD46 and oncologic interactions [PDF]
The Journal of Clinical InvestigationInitially identified as a regulator of complement activation on host cells, the known roles of CD46 (membrane cofactor protein [MCP]) have expanded. We now know that this ancient molecule is expressed on almost all nucleated cells as a family of four ...
M. Kathryn Liszewski, John P. Atkinson
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CD46 and Oncologic Interactions: Friendly Fire against Cancer
Antibodies, 2020 One of the most challenging aspects of cancer therapeutics is target selection. Recently, CD46 (membrane cofactor protein; MCP) has emerged as a key player in both malignant transformation as well as in cancer treatments.
John Atkinson +2 more
exaly +3 more sources
Molecular Therapy - Nucleic Acids, 2021 CD46 is well known to be involved in diverse biological processes. Although several splice variants of CD46 have been identified, little is known about the contribution of alternative splicing to its tumorigenic functions.
Wei Xiao, Hui Zhou, Wei Xiao
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Identification of a new CD46 gene mutation site in a family with atypical hemolytic uremic syndrome [PDF]
BMC NephrologyBackground Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy resulting from the dysregulation of the alternative complement pathway.
Benjin Hu +6 more
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CD46 is a cellular receptor for species D human adenovirus [PDF]
mBioHuman adenovirus species D (HAdV-D) contains two-thirds of all known HAdV types (116 in total) and is important as a vector in clinical applications. However, the broad tropism exhibited by several HAdV-D types poses challenges for their use as targeted ...
Katarina Danskog +6 more
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Primary Cells from a CD46-Edited Bovine Heifer Have Reduced BVDV Susceptibility Despite Viral Adaptation to Heparan Sulfate [PDF]
VirusesA precision genome edit in the bovine CD46 gene (A82LPTFS87) dramatically reduced bovine viral diarrhea virus (BVDV) susceptibility in a cloned heifer. However, pathogen evolution threatens the long-term efficacy of such interventions.
Alexandria C. Krueger +4 more
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CD46 TREM1 regulates the autophagy marker LC3B ATG5 in oral squamous cell carcinoma [PDF]
Frontiers in OncologyObjectiveThis study aims to explore the regulatory effect of abnormal expression of CD46 and TREM1 on LC3B and ATG5 and to provide new targets for the molecular mechanism and treatment of OSCC.
Xiaodan Liu +8 more
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CD46 Gene Editing Confers Ex Vivo BVDV Resistance in Fibroblasts from Cloned Angus Calves [PDF]
VirusesA previous study demonstrated that a 19-nucleotide edit, encoding a six amino acid substitution in the bovine CD46 gene, dramatically reduced bovine viral diarrhea virus (BVDV) susceptibility in a cloned Gir (Bos indicus) heifer.
Aspen M. Workman +2 more
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Inhibition of cd46 receptor by rnai enhances cell resistance to bvdv infection [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020 This study aimed to investigate the inhibition effect of CD46 on the replication of bovine viral diarrhea viruses (BVDV). BVDV causes bovine viral diarrheal mucosal disease, and prevention of BVDV infection is very important for livestock production ...
Ruirui HU +7 more
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CD46 Genetic Variability and HIV-1 Infection Susceptibility
Cells, 2021 CD46 is the main receptor for complement protein C3 and plays an important role in adaptive immune responses. CD46 genetic variants are associated with susceptibility to several infectious and autoimmune diseases.
Carmen Serrano-Rísquez +12 more
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