Results 11 to 20 of about 9,091 (172)
Structure of Bovine CD46 Ectodomain
Viruses, 2023 CD46, or membrane cofactor protein, is a type-one transmembrane protein from the complement regulatory protein family. Alongside its role in complement activation, CD46 is involved in many other processes, from T-cell activation to reproduction.
Hazel Aitkenhead +2 more
doaj +3 more sources
A novel role for CD46 in wound repair [PDF]
Frontiers in Immunology, 2011 The intestinal epithelium not only provides a vital physical barrier between the host and environment but is also required for uptake of nutrients and the induction of tolerance against commensals.
John eCardone +2 more
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Calcitriol modulates the CD46 pathway in T cells.
PLoS ONE, 2012 The complement regulator CD46 is a costimulatory molecule for human T cells that induces a regulatory Tr1 phenotype, characterized by large amounts of IL-10 secretion.
Karoline Kickler +4 more
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Role of CD46 in Measles Virus Infection in CD46 Transgenic Mice [PDF]
Virology, 1998 The susceptibility of CD46 (human membrane cofactor protein) transgenic mice to measles virus (MV) infection was investigated. Cell cultures (lung and kidney) established from transgenic and control mice showed that although both could be infected only those from the CD46+ mice gave fusion. A complete round of replication with the release of infectious
Blixenkrone-Møller, M. +6 more
openaire +2 more sources
Morbillivirus Downregulation of CD46 [PDF]
Journal of Virology, 1998 ABSTRACTThere is evidence that CD46 (membrane cofactor protein) is a cellular receptor for vaccine and laboratory-passaged strains of measles virus (MV). Following infection with these MV strains, CD46 is downregulated from the cell surface, and consequent complement-mediated lysis has been shown to occur upon infection of a human monocytic cell line ...
S E, Galbraith +5 more
openaire +2 more sources
Real Time Analysis of Bovine Viral Diarrhea Virus (BVDV) Infection and Its Dependence on Bovine CD46
Viruses, 2020 Virus attachment and entry is a complex interplay of viral and cellular interaction partners. Employing bovine viral diarrhea virus (BVDV) encoding an mCherry-E2 fusion protein (BVDVE2-mCherry), being the first genetically labelled member of the family ...
Christiane Riedel +5 more
doaj +1 more source
Infection of polarized bovine respiratory epithelial cells by bovine viral diarrhea virus (BVDV)
Virulence, 2021 Bovine viral diarrhea virus (BVDV) is affecting cattle populations all over the world causing acute disease, immunosuppressive effects, respiratory diseases, gastrointestinal, and reproductive failure in cattle.
Ang Su +6 more
doaj +1 more source
Sensitive detection systems for infectious agents in xenotransplantation*
Xenotransplantation, EarlyView., 2020 Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley +1 more source
Structure of the extracellular portion of CD46 provides insights into its interactions with complement proteins and pathogens. [PDF]
PLoS Pathogens, 2010 The human membrane cofactor protein (MCP, CD46) is a central component of the innate immune system. CD46 protects autologous cells from complement attack by binding to complement proteins C3b and C4b and serving as a cofactor for their cleavage.
B David Persson +7 more
doaj +1 more source
Function of complement regulatory proteins in immunity of reproduction: a review
Czech Journal of Animal Science, 2005 Humoral immunity has an important role during the maturation and development of the functional properties of spermatozoa. Spermatozoa may be exposed to antisperm antibodies in semen and in cervical, ovarian follicular and fallopian fluid.
J. Valentovičová +2 more
doaj +1 more source