Results 21 to 30 of about 9,091 (172)
CD46 processing: A means of expression [PDF]
Immunobiology, 2012 CD46 is a ubiquitously expressed type I transmembrane protein, first identified as a regulator of complement activation, and later as an entry receptor for a variety of pathogens. The last decade has also revealed the role of CD46 in regulating the adaptive immune response, acting as an additional costimulatory molecule for human T cells and inducing ...
Ni Choileain, Siobhan, Astier, Anne
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Viral Traits and Cellular Knock-Out Genotype Affect Dependence of BVDV on Bovine CD46
Pathogens, 2021 The role of bovine CD46 in the host cell entry of BVDV has been established for more than a decade. By generating novel MDBK CD46 knock-out clones, we confirm previously reported data on the CD46 motives important for BVDV binding and the importance of ...
Hann-Wei Chen +6 more
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Инфекция и иммунитет, 2023 The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to global morbidity and mortality. Some patients fully recover from COVID-19, whereas around 45% subjects suffer from various persistent symptoms (fatigue, cognitive impairment, impaired ...
Maria A. Dobrynina +6 more
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Reproductive Biology and Endocrinology, 2009 Background In rodents, the cell surface complement regulatory protein CD46 is expressed solely on the spermatozoal acrosome membrane. Ablation of the CD46 gene is associated with a faster acrosome reaction.
Flanagan Brian F +7 more
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CD46 protects the bladder cancer cells from cetuximab-mediated cytotoxicity
Scientific Reports, 2022 Epidermal growth factor receptor (EGFR) is an effective target for those patients with metastatic colorectal cancers that retain the wild-type RAS gene. However, its efficacy in many cancers, including bladder cancer, is unclear.
Manh-Hung Do +5 more
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Autophagy Induction by the Pathogen Receptor CD46 [PDF]
Cell Host & Microbe, 2009 Autophagy is a highly regulated self-degradative mechanism required at a basal level for intracellular clearance and recycling of cytoplasmic contents. Upon intracellular pathogen invasion, autophagy can be induced as an innate immune mechanism to control infection.
Joubert, Pierre-Emmanuel +12 more
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Localization of Regions in CD46 That Interact with Adenovirus [PDF]
Journal of Virology, 2005 ABSTRACTA variety of pathogens use CD46, a ubiquitously expressed membrane protein that regulates complement activation, as a cellular attachment receptor. While the CD46 binding sites of several pathogens, including measles virus,Neisseria gonorrhea, and human herpesvirus 6, have been described, the region of CD46 responsible for adenovirus binding ...
Anuj, Gaggar +4 more
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Emerging Microbes and Infections, 2022 The genus Pestivirus within the family Flaviviridae comprises highly relevant animal pathogens such as bovine viral diarrhoea virus 1 and 2 (BVDV-1 and -2) classified into the two species Pestivirus A and Pestivirus B, respectively.
Elena Leveringhaus +4 more
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Viruses, 2023 This study examines an unexplored aspect of SARS-CoV-2 entry into host cells, which is widely understood to occur via the viral spike (S) protein’s interaction with human ACE2-associated proteins.
Pavel Vassiliev +5 more
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Complements and Allergic Asthma
Pediatric Respirology and Critical Care Medicine, 2019 Regulatory T (Treg) cells play a central role in protecting against the development of allergic asthma and interleukin-10 (IL-10) producing T regulatory type 1 (Tr1) cells contribute to the regulation of asthma.
Ching-Yuang Lin, Yi-Giien Tsai
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