Results 31 to 40 of about 9,091 (172)

CD46 Is a Cellular Receptor for Human Herpesvirus 6 [PDF]

Cell, 1999
Human herpesvirus 6 (HHV-6) is the etiologic agent of exanthema subitum, causes opportunistic infections in immunocompromised patients, and has been implicated in multiple sclerosis and in the progression of AIDS. Here, we show that the two major HHV-6 subgroups (A and B) use human CD46 as a cellular receptor.
SANTORO F., KENNEDY P. E., LOCATELLI G., MALNATI M. S., BERGER E. A., LUSSO, PAOLO   +5 more
openaire   +3 more sources

MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke. [PDF]

PLoS ONE, 2017
Ischemic stroke is a major cause of mortality and morbidity globally. Among the ischemic stroke subtypes, cardioembolic stroke is with poor functional outcome (Modified Rankin score ≥ 2).
Jun Rong Tan, Kay Sin Tan, Fung Lin Yong, Arunmozhiarasi Armugam, Chee Woon Wang, Kandiah Jeyaseelan, Peter Tsun-Hon Wong   +6 more
doaj   +1 more source

CD46 Is a Protein Receptor for Human Adenovirus Type 64

Viruses
Certain species D human adenoviruses (HAdV-D19, -D37, and -D64) are causative agents of epidemic keratoconjunctivitis. HAdV-D37 has previously been shown to bind CD46 (membrane cofactor protein) and sialic acid as adhesion receptors.
Eugene Y. Wu, Alexander M. Robertson, Hanglin (Henry) Zhu, Corina Stasiak, Laura A. Murray-Nerger, Emily Romanoff, Jesse Woon, Beth A. Bromme, Jason G. Smith   +8 more
doaj   +1 more source

A CRISPR/Cas9 Generated Bovine CD46-knockout Cell Line—A Tool to Elucidate the Adaptability of Bovine Viral Diarrhea Viruses (BVDV)

Viruses, 2020
Bovine viral diarrhea virus (BVDV) entry into a host cell is mediated by the interaction of the viral glycoprotein E2 with the cellular transmembrane CD46 receptor.
Kevin P. Szillat, Susanne Koethe, Kerstin Wernike, Dirk Höper, Martin Beer   +4 more
doaj   +1 more source

The complement regulatory protein CD46 serves as a novel biomarker for cervical cancer diagnosis and prognosis evaluation

Frontiers in Immunology
BackgroundCD46 has been revealed to be a key factor in malignant transformation and cancer treatment. However, the clinical significance of CD46 in cervical cancer remains unclear, and this study aimed to evaluate its role in cervical cancer diagnosis ...
Jun-Hui Yu, Hao-Bo Yuan, Zi-Yi Yan, Xia Zhang, Hui-Hui Xu   +4 more
doaj   +1 more source

Quantitative expression analysis of HHV-6 cell receptor CD46 on cells of human cord blood, peripheral blood and G-CSF mobilised leukapheresis cells

Virology Journal, 2006
Human herpesvirus-6 (HHV-6) can infect blood cells and thereby may inhibit hematopoietic stem and progenitor cell expansion and differentiation. In this context, it has been discussed if early progenitor cells can be infected by HHV-6.
Thulke Stefanie, Radonić Aleksandar, Nitsche Andreas, Siegert Wolfgang   +3 more
doaj   +1 more source

Interaction of CD46 with measles virus: accessory role of CD46 short consensus repeat IV

Journal of General Virology, 2000
To define further the accessory role(s) of the CD46 (membrane cofactor protein) short consensus repeat (SCR) III and IV domains in the interaction of CD46 with measles virus (MV), chimeric proteins were generated by substituting domains from the structurally related protein decay accelerating factor (DAF, CD55): x3DAF (exchange of CD46 SCR III) and ...
Lanteri, Marc, Christiansen, Dale, Gerlier, Denis, Kyriakou, Peter, Loveland, Bruce, Escoffier, Carine   +5 more
openaire   +3 more sources

Vitamin D/CD46 Crosstalk in Human T Cells in Multiple Sclerosis

Frontiers in Immunology, 2020
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), in which T-cell migration into the CNS is key for pathogenesis. Patients with MS exhibit impaired regulatory T cell populations, and both Foxp3+ Tregs and type
Justin Killick, Justin Killick, Joanne Hay, Joanne Hay, Elena Morandi, Sonja Vermeren, Saniya Kari, Thibault Angles, Anna Williams, Anna Williams, Jan Damoiseaux, Anne L. Astier, Anne L. Astier, Anne L. Astier   +13 more
doaj   +1 more source

MeV-Stealth: A CD46-specific oncolytic measles virus resistant to neutralization by measles-immune human serum.

PLoS Pathogens, 2021
The frequent overexpression of CD46 in malignant tumors has provided a basis to use vaccine-lineage measles virus (MeV) as an oncolytic virotherapy platform.
Miguel Ángel Muñoz-Alía, Rebecca A Nace, Alexander Tischer, Lianwen Zhang, Eugene S Bah, Matthew Auton, Stephen J Russell   +6 more
doaj   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source