Results 41 to 50 of about 104,326 (289)

Expression of membrane cofactor protein (MCP, CD46) in human liver diseases [PDF]

British Journal of Cancer, 1999
Membrane cofactor protein (MCP, CD46) is one of the complement regulatory proteins, and is widely distributed in human organs and protects cells from complement-mediated cytotoxicity. We analysed the distribution and the intensities of MCP in liver diseases and evaluated the role of MCP during hepatocarcinogenesis.
Kinugasa, N, Higashi, T, Nouso, K, Nakatsukasa, H, Kobayashi, Y, Ishizaki, M, Toshikuni, N, Yoshida, K, Uematsu, S, Tsuji, T   +9 more
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Vibrio natriegens as Host for Expression of Multisubunit Membrane Protein Complexes

Frontiers in Microbiology, 2018
Escherichia coli is a convenient host for the expression of proteins, but the heterologous production of large membrane protein complexes often is hampered by the lack of specific accessory genes required for membrane insertion or cofactor assembly.
Lena Schleicher, Valentin Muras, Björn Claussen, Jens Pfannstiel, Bastian Blombach, Pavel Dibrov, Günter Fritz, Günter Fritz, Julia Steuber   +8 more
doaj   +1 more source

Protein Amphipathic Helix Insertion: A Mechanism to Induce Membrane Fission

Frontiers in Cell and Developmental Biology, 2019
One of the fundamental features of biomembranes is the ability to fuse or to separate. These processes called respectively membrane fusion and fission are central in the homeostasis of events such as those related to intracellular membrane traffic ...
Mikhail A. Zhukovsky, Angela Filograna, Alberto Luini, Daniela Corda, Carmen Valente   +4 more
doaj   +1 more source

Reproductive Characteristic of Transgenic Massachusetts General Hospital Miniature Pigs for Xenotransplantation

Journal of Animal Reproduction and Biotechnology, 2017
Pigs have been extensively used as mediators of xenotransplantation research. Specifically, the Massachusetts General Hospital (MGH) miniature pig was developed to fix major histocompatibility antigens for use in xenotransplantation studies. We generated
Soo-Jeong Ji, Gunsup Lee, Sang Hyoun Park, Kyung Woon Kim, Sung-June Byun, Sun A Ock, Seongsoo Hwang, Jae-Seok Woo, Keon Bong Oh   +8 more
doaj   +1 more source

The M18 aspartyl aminopeptidase of Plasmodium falciparum binds to human erythrocyte spectrin in vitro

Malaria Journal, 2008
Background During erythrocytic schizogony, Plasmodium falciparum interacts with the human erythrocyte membrane when it enters into, grows within and escapes from the erythrocyte. An interaction between the P.
Coetzer Theresa L, Lauterbach Sonja B
doaj   +1 more source

Molecular Studies and an ex vivo Complement Assay on Endothelium Highlight the Genetic Complexity of Atypical Hemolytic Uremic Syndrome: The Case of a Pedigree With a Null CD46 Variant

Frontiers in Medicine, 2020
Atypical hemolytic uremic syndrome (aHUS) is an ultra-rare disease characterized by microangiopathic hemolysis, thrombocytopenia, and renal impairment and is associated with dysregulation of the alternative complement pathway on the microvascular ...
Rossella Piras, Paraskevas Iatropoulos, Elena Bresin, Marta Todeschini, Sara Gastoldi, Elisabetta Valoti, Marta Alberti, Caterina Mele, Miriam Galbusera, Paola Cuccarolo, Ariela Benigni, Giuseppe Remuzzi, Marina Noris   +12 more
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CD46 Is a Protein Receptor for Human Adenovirus Type 64

Viruses
Certain species D human adenoviruses (HAdV-D19, -D37, and -D64) are causative agents of epidemic keratoconjunctivitis. HAdV-D37 has previously been shown to bind CD46 (membrane cofactor protein) and sialic acid as adhesion receptors.
Eugene Y. Wu, Alexander M. Robertson, Hanglin (Henry) Zhu, Corina Stasiak, Laura A. Murray-Nerger, Emily Romanoff, Jesse Woon, Beth A. Bromme, Jason G. Smith   +8 more
doaj   +1 more source

TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP). [PDF]

PLoS Pathogens, 2017
The host factor and interferon (IFN)-stimulated gene (ISG) product, zinc-finger antiviral protein (ZAP), inhibits a number of diverse viruses by usurping and intersecting with multiple cellular pathways. To elucidate its antiviral mechanism, we perform a
Melody M H Li, Zerlina Lau, Pamela Cheung, Eduardo G Aguilar, William M Schneider, Leonia Bozzacco, Henrik Molina, Eugen Buehler, Akinori Takaoka, Charles M Rice, Dan P Felsenfeld, Margaret R MacDonald   +11 more
doaj   +1 more source

Cooperation of decay-accelerating factor and membrane cofactor protein in regulating survival of human cervical cancer cells

BMC Cancer, 2009
Background Decay-accelerating factor (DAF) and membrane cofactor protein (MCP) are the key molecules involved in cell protection against autologus complement, which restricts the action of complement at critical stages of the cascade reaction.
Gong Hui, Su Ya-Juan, Gu Ping-Qing, Cai You-Qun, Guo Shu-Yu, Gao Ling-Juan, Liu Yun, Chen Chen   +7 more
doaj   +1 more source

A Novel and Ubiquitous System for Membrane Targeting and Secretion of Cofactor-Containing Proteins [PDF]

Cell, 1998
We report the identification of the proteins encoded by the mttABC operon (formerly yigTUW), which mediate a novel Sec-independent membrane targeting and translocation system in Escherichia coli that interacts with cofactor-containing redox proteins having a S/TRRXFLK "twin arginine" leader motif.
Weiner, Joel H, Bilous, Peter T, Shaw, Gillian M, Lubitz, Shannon P, Frost, Laura, Thomas, Gavin H, Cole, Jeff A, Turner, Raymond J   +7 more
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