Results 31 to 40 of about 1,697 (143)

Control of complement activation in membranous and membranoproliferative glomerulonephritis [PDF]

, 1980
Control of complement activation in membranous and membranoproliferative glomerulonephritis. Renal biopsy specimens from 22 membranous (MGN) and 19 membranoproliferative glomerulonephritis (MPGN) patients were examined for the presence of the three ...
Moseley, Hannah L., Whaley, Keith
core   +1 more source

Silica Induced Suppression of the Production of Third and Fifth Components of the Complement System by Human Lung Cells In Vitro [PDF]

, 1994
Although investigations to date have demonstrated the ability of the monocyte/macrophage to synthesize complement components, only a limited number of studies on complement synthesis by nonhepatic tissue cells have been reported.
Kennedy, Thomas,, Rothman, Barbara L., Rothman, Barbara L.,, Contrino, Josephine, Despins, Alan, Merrow, Martha,, Kennedy, Thomas, Kreutzer, Donald L., Contrino, Josephine,, Despins, Alan,, Kreutzer, Donald L.,, Merrow, Martha   +11 more
core   +1 more source

The Arabidopsis Mutant of the Small Intrinsically Disordered Protein DSS1(V) Exhibits Increased Sensitivity to Drought Stress

Plant Direct, Volume 10, Issue 2, February 2026.
ABSTRACT Drought has emerged as one of the most severe and widespread environmental stresses affecting plants. Crops exposed to varying levels of drought, ranging from moderate to severe, often experience notable declines in yield or reduced harvest quality.
Ivana Nikolic, Maja Sabljic, Mira Milisavljevic, Ivan Radin, Gordana Timotijevic   +4 more
wiley   +1 more source

A Review of β‐Lactamase Inhibitors in Clinical Use and Development: Mechanisms, Spectrum, and Therapeutic Applications

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
β‐Lactam antibiotics have long served as a cornerstone for treating bacterial infections. However, their widespread and often indiscriminate use has fueled the emergence of multidrug‐resistant Gram‐negative pathogens, primarily through the production and dissemination of β‐lactamase enzymes.
Mohammad Javad Roustaye Gourabi, Anita Nikoo, Bita Khanbabaei, Masoud Kargar, Amirhossein Fayyazi, Seyyed Mohammad Javad Mousavi, Amirhossein Aghdaee, Ali Hashemi, Javad Yasbolaghi Sharahi, Swaran J. S. Flora   +9 more
wiley   +1 more source

Progress in Molecular Imprinting—From Inhibition of Enzymatic Activity to Regulation of Cellular Pathways

Medicinal Research Reviews, Volume 45, Issue 6, Page 1662-1678, November 2025.
ABSTRACT Molecular imprinting is a very powerful tool in life science. The research areas benefiting from a wide range of capabilities of molecularly imprinted polymeric nanoparticles (nanoMIPs) include sample preparation, extraction, sensing/detection, diagnostics, and drug delivery.
Milada Vodova, Jaroslava Bezdekova, Marketa Vaculovicova   +2 more
wiley   +1 more source

Interaction of S-protein of complement with thrombin and antithrombin III during coagulation. Protection of thrombin by S-protein from antithrombin III inactivation.

Journal of Biological Chemistry, 1986
S-protein, the inhibitor in plasma of the membrane attack complex of complement, appears to have a second function in coagulation. S-protein during clotting enters into a trimolecular complex with thrombin and antithrombin III (ATIII). Functionally, S-protein in the presence of low concentrations of heparin, protects thrombin from inactivation by ATIII.
E R, Podack, B, Dahlbäck, J H, Griffin
openaire   +2 more sources

Piceatannol, a Natural Polyphenol From Grape, Inhibits Helicobacter pylori Through Targeted Suppression of Its Secreted Urease

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
Piceatannol significantly inhibits the growth of Helicobacter pylori through targeted suppression of its secreted urease activity. The inhibition of piceatannol against H. pylori urease (HPU) and jack bean urease (JBU) was characterized in a slow‐binding, mixed‐type and slow‐binding, noncompetitive type, respectively.
Qiang Lu, Yuhong Xie, Xuefei Wang, Haohui Chen, Yifei Xu, Cailan Li   +5 more
wiley   +1 more source

Detection of Sulfoquinovosidase Activity in Cell Lysates Using Activity‐Based Probes

Angewandte Chemie, Volume 136, Issue 26, June 21, 2024.
The development of activity‐based probes targeting the active site nucleophile of glycoside hydrolase family 31 sulfoquinovosidases is described. The probes are shown to bind covalently by structural biology, mass spectrometry and Cy5 in‐gel fluorescence, are selective for sulfoquinovosidases in whole bacterial cell lysates, and are used to monitor ...
Zirui Li, Isabelle B. Pickles, Mahima Sharma, Benjamin Melling, Luise Pallasdies, Jeroen D. C. Codée, Spencer J. Williams, Herman S. Overkleeft, Gideon J. Davies   +8 more
wiley   +2 more sources

Beyond the Binary: Controlling Natural Sex‐Change in Hermaphroditic Fishes

Reviews in Aquaculture, Volume 17, Issue 4, September 2025.
ABSTRACT Sex‐change in hermaphroditic fishes is a complex but natural biological phenomenon that has significant implications for aquaculture fingerling production, selective breeding, and grow‐out. Understanding the physiological, endocrinological, and molecular pathways underlying hermaphroditism in fishes offers unique opportunities to manipulate ...
Roni Chandra Mondal, Jarrod L. Guppy, Maria A. Villacis‐Escobar, Dean R. Jerry   +3 more
wiley   +1 more source

Relevance of G protein‐coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation

British Journal of Pharmacology, Volume 182, Issue 14, Page 3211-3224, July 2025.
Abstract G protein‐coupled receptors (GPCRs) are one of the major drug targets. In recent years, computational drug design for GPCRs has mainly focused on static structures obtained through X‐ray crystallography, cryogenic electron microscopy (cryo‐EM) or in silico modelling as a starting point for virtual screening campaigns. However, GPCRs are highly
Marta Lopez‐Balastegui, Tomasz Maciej Stepniewski, Małgorzata M. Kogut‐Günthel, Antonella Di Pizio, Mette Marie Rosenkilde, Jiafei Mao, Jana Selent   +6 more
wiley   +1 more source