Results 11 to 20 of about 113,435 (208)
Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. [PDF]
Journal of Experimental Medicine, 1977 The complement regulatory enzyme, C3b inactivator (C3bINA), has been purified from human serum by affinity chromatography on an anti-C3bINA Sepharose column.
Robert D Schreiber
exaly +4 more sources
Journal of Immunology, 1978 Radioiodinated β1H was demonstrated to bind to sheep EAC4b, EAC4,2,3b and EC3b, but not to E, EA, EAC4,2 or to C3bINA and β1H treated EC3b. This binding was dependent upon the C3b concentration on the surface of the cells and could be inhibited by ...
M. K. Pangburn +2 more
exaly +3 more sources
The C3b inactivator of the human complement system: homology with serine proteases
FEBS Letters, 1981 A. Davis
exaly +2 more sources
Development of Efficient Covalent Inactivators of a Fungal Aspartate Semialdehyde Dehydrogenase. [PDF]
Drug Dev ResABSTRACT Aspartate semialdehyde dehydrogenase (ASADH) catalyzes the second step in the fungal pathway towards the synthesis of threonine, isoleucine, and methionine, and it has been identified as a viable target for antifungal drug development. Our previous work produced a group of vinyl sulfones that function as irreversible covalent inactivators of ...
Friday SN +14 more
europepmc +2 more sources
Purification of the human complement control protein C3b inactivator [PDF]
Biochemical Journal, 1980 An alternative method of isolation from human plasma is described for C3b inactivator, C3bINA, the proteinase that in conjunction with either beta 1H or C4b-binding protein will hydrolyse respectively C3b or C4b, the activation products of the third, C3 and fourth, C4, components of complement. The purification is by chromatography of plasma on columns
L G, Crossley, R R, Porter
openaire +2 more sources
Glycation Inactivation of the Complement Regulatory Protein CD59 [PDF]
Diabetes, 2004 Micro- and macrovascular diseases are major causes of morbidity and mortality in the diabetic population, but the cellular and molecular mechanisms that link hyperglycemia to these complications remain incompletely understood. We proposed that in human diabetes, inhibition by glycation of the complement regulatory protein CD59 increases deposition of ...
Xuebin Qin +7 more
openaire +1 more source
Structural Complementation of a Monomeric Ribosomal-Inactivating Protein [PDF]
Biophysical Journal, 2013 Exotoxin A (ETA) from the Gram-negative bacterium Pseudomonas aeruginosa is a ribosomal-inactivating protein (RIP) that acts by ADP-ribosylation of the post-translationally modified histidine, diphthamide, in elongation factor 2. Apoptotic cell death typically ensues upon intoxication.
Boland, Erin L. +2 more
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Complement regulatory proteins are incorporated into lentiviral vectors and protect particles against complement inactivation [PDF]
Gene Therapy, 2004 Lentiviral vectors pseudotyped with G glycoprotein from vesicular stomatitis virus (VSV-G) and baculovirus gp64 are inactivated by human complement. The extent of vector inactivation in serum from individual donors was examined and results showed wide donor-dependent variation in complement sensitivity for VSV-G-pseudotyped lentivectors.
C, Schauber-Plewa +4 more
openaire +2 more sources
International Brazilian Journal of Urology, 2012 Purpose To investigate the use of ClinProt technique to identify cancer markers in plasma of patients suffering from squamous cell carcinoma of the penis (SCCP). Materials and Methods Plasma of 36 healthy subjects and 25 patients with
Paulo Ornellas +12 more
doaj +1 more source