Results 11 to 20 of about 305,759 (329)

Combating Complement's Deleterious Effects on Nanomedicine by Conjugating Complement Regulatory Proteins to Nanoparticles [PDF]

Advanced Materials, 2022
AbstractComplement opsonization is among the biggest challenges facing nanomedicine. Nearly instantly after injection into blood, nanoparticles are opsonized by the complement protein C3, leading to clearance by phagocytes, fouling of targeting moieties, and release of anaphylatoxins. While surface polymers such as poly(ethylene glycol) (PEG) partially
Zhicheng Wang, Elizabeth D. Hood, Jia Nong, Jing Ding, Oscar A. Marcos‐Contreras, Patrick M. Glassman, Kathryn M. Rubey, Michael Zaleski, Carolann L. Espy, Damodara Gullipali, Takashi Miwa, Vladimir R. Muzykantov, Wen‐Chao Song, Jacob W. Myerson, Jacob S. Brenner   +14 more
europepmc   +5 more sources

Role of Complement and Complement Regulatory Proteins in the Complications of Diabetes

Endocrine Reviews, 2015
It is well established that the organ damage that complicates human diabetes is caused by prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels of glucose cause tissue damage in humans are still not fully understood.
Pamela, Ghosh, Rupam, Sahoo, Anand, Vaidya, Michael, Chorev, Jose A, Halperin   +4 more
europepmc   +6 more sources

Entamoeba histolytica Develops Resistance to Complement Deposition and Lysis after Acquisition of Human Complement-Regulatory Proteins through Trogocytosis [PDF]

mBio, 2022
Entamoeba histolytica is the cause of amoebiasis. The trophozoite (amoeba) form of this parasite is capable of invading the intestine and can disseminate through the bloodstream to other organs.
Hannah W. Miller, Tammie S. Y. Tam, Katherine S. Ralston   +2 more
doaj   +2 more sources

Complement-regulatory proteins in ovarian malignancies [PDF]

International Journal of Cancer, 1997
Ovarian cancer has features that makes it well-suited for MAb adjuvant immunotherapy. Several of the MAbs used in clinical trials mediate cancer cell destruction by activation of complement (C). In this study, therefore, we examined the ability of ovarian-tumor cells to resist C attack.
Line Bjørge, Juha Hakulinen, Torsten Wahlström, Roald Matre, Seppo Meri   +4 more
openalex   +3 more sources

SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins [PDF]

Emerging Microbes and Infections
Complement hyperactivation and thrombotic microangiopathy are closely associated with severe COVID-19. Endothelial dysfunction is a key mechanism underlying thrombotic microangiopathy.
Jian Wu, Sanpeng Xu, Zhiqing Li, Boyi Cong, Zongheng Yang, Zhichao Yang, Wanfeng Gao, Shuo Liu, Zhou Yu, Sheng Xu, Nan Li, Jin Hou, Guoping Wang, Xuetao Cao, Shuxun Liu   +14 more
doaj   +2 more sources

Altered expression of complement regulatory proteins CD35 and CD59 in acute lymphoblastic and acute myeloblastic leukemia suggests a context-based pattern [PDF]

Discover Oncology
The complement system is a vital part of the innate immune defense, playing a key role in clearing immune complexes; however, its activity must be carefully regulated to avoid damage to healthy cells.
Reem Hossam EL-Din Ahmed, Menatalla Mostafa Mahmoud, Mohamed Ahmed El-Azizi, Noha Samir Farag   +3 more
doaj   +2 more sources

Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. [PDF]

PLoS Medicine, 2011
Pregnancy in women with systemic lupus erythematosus (SLE) or antiphospholipid antibodies (APL Ab)--autoimmune conditions characterized by complement-mediated injury--is associated with increased risk of preeclampsia and miscarriage. Our previous studies
Jane E Salmon, Cara Heuser, Michael Triebwasser, M Kathryn Liszewski, David Kavanagh, Lubka Roumenina, D Ware Branch, Tim Goodship, Veronique Fremeaux-Bacchi, John P Atkinson   +9 more
doaj   +3 more sources

SARS-CoV-2 nucleocapsid protein forms complexes with soluble complement regulatory proteins that can bind to the virion [PDF]

Scientific Reports
The SARS-CoV-2 nucleocapsid protein has been detected in the plasma of COVID-19 patients, and its levels in the plasma correlate with the severity of the disease. It is also an immunomodulatory protein, triggering the release of proinflammatory cytokines.
Jakub Víglaský, Katarína Bhide, Lea Talpasova, Ľubica Fialová, Mangesh Bhide   +4 more
doaj   +2 more sources

Complement regulatory proteins are associated with progression rate of geographic atrophy secondary to age-related macular degeneration [PDF]

Immunity & Ageing
Background Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a progressive degenerative disease leading to irreversible vision loss in elderly individuals.
Jenni Martinez Villarruel Hinnerskov, Marie Krogh Nielsen, Alexander Kai Thomsen, Maria Abildgaard Steffensen, Bent Honoré, Henrik Vorum, Mogens Holst Nissen, Torben Lykke Sørensen   +7 more
doaj   +2 more sources

Review: Complement and its regulatory proteins in kidney diseases [PDF]

Nephrology, 2010
ABSTRACTComplement is a part of the body's innate immune system that helps defend the host from microbial infection. It is tightly controlled by a number of cell surface and fluid‐phase proteins so that under normal circumstances injury to autologous tissues is avoided.
Allison M. Lesher, Wen‐Chao Song
openalex   +3 more sources