Results 11 to 20 of about 173,706 (280)

Entamoeba histolytica Develops Resistance to Complement Deposition and Lysis after Acquisition of Human Complement-Regulatory Proteins through Trogocytosis [PDF]

mBio, 2022
Entamoeba histolytica is the cause of amoebiasis. The trophozoite (amoeba) form of this parasite is capable of invading the intestine and can disseminate through the bloodstream to other organs.
Hannah W. Miller, Tammie S. Y. Tam, Katherine S. Ralston   +2 more
doaj   +2 more sources

Combating Complement's Deleterious Effects on Nanomedicine by Conjugating Complement Regulatory Proteins to Nanoparticles. [PDF]

Adv Mater, 2022
AbstractComplement opsonization is among the biggest challenges facing nanomedicine. Nearly instantly after injection into blood, nanoparticles are opsonized by the complement protein C3, leading to clearance by phagocytes, fouling of targeting moieties, and release of anaphylatoxins. While surface polymers such as poly(ethylene glycol) (PEG) partially
Wang Z, Hood ED, Nong J, Ding J, Marcos-Contreras OA, Glassman PM, Rubey KM, Zaleski M, Espy CL, Gullipali D, Miwa T, Muzykantov VR, Song WC, Myerson JW, Brenner JS.   +14 more
europepmc   +3 more sources

Upregulation of complement proteins in lung cancer cells mediates tumor progression [PDF]

Frontiers in Oncology, 2023
IntroductionIn vivo, cancer cells respond to signals from the tumor microenvironment resulting in changes in expression of proteins that promote tumor progression and suppress anti-tumor immunity.
Emily K. Kleczko, Joanna M. Poczobutt, Andre C. Navarro, Jennifer Laskowski, Amber M. Johnson, Sean P. Korpela, Natalia J. Gurule, Lynn E. Heasley, Katharina Hopp, Mary C.M. Weiser-Evans, Elizabeth B. Gottlin, Ryan T. Bushey, Michael J. Campa, Edward F. Patz, Edward F. Patz, Joshua M. Thurman, Raphael A. Nemenoff   +16 more
doaj   +2 more sources

Complement regulatory proteins in glomerular diseases [PDF]

Kidney International, 1998
Complement activation plays a critical role in the pathogenesis of many forms of glomerulonephritis. Complement activation leads to tissue injury through various mechanisms including the generation of chemotactic factors and activation of the resident glomerular cells following C5b-9 insertion.
Nangaku, Masaomi
openaire   +3 more sources

Binding of complement regulatory proteins to Group A Streptococcus [PDF]

Vaccine, 2008
Streptococcus pyogenes or Group A Streptococcus (GAS) is the etiologic agent of important human infections such as acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Binding of the complement regulatory proteins factor H, factor H-like protein 1 (FHL-1), C4b-binding protein (C4BP), or CD46 is a crucial step in the ...
Oliver, María Antonia, Rojo, José María, Rodríguez de Córdoba, Santiago, Albertí, Sebastián   +3 more
openaire   +4 more sources

Role of complement and complement regulatory proteins in the complications of diabetes.

Endocr Rev, 2015
It is well established that the organ damage that complicates human diabetes is caused by prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels of glucose cause tissue damage in humans are still not fully understood.
Ghosh P, Sahoo R, Vaidya A, Chorev M, Halperin JA.   +4 more
europepmc   +4 more sources

Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi. [PDF]

PLoS ONE, 2010
One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular to complement-mediated killing. Serum-resistant B. burgdorferi express up to five distinct complement regulator-acquiring surface proteins (CRASP) which ...
Corinna Siegel, Teresia Hallström, Christine Skerka, Hannes Eberhardt, Barbara Uzonyi, Tobias Beckhaus, Michael Karas, Reinhard Wallich, Brian Stevenson, Peter F Zipfel, Peter Kraiczy   +10 more
doaj   +3 more sources

Expression levels of complement regulatory proteins (CD35, CD55 and CD59) on peripheral blood cells of patients with chronic kidney disease [PDF]

International Journal of General Medicine, 2019
Dalia Mahmoud Eldewi,1 Alshaymaa M Alhabibi,1 Hanaa Mohammed Eid El Sayed,2 Sammar Ahmed Kasim Mahmoud,2 Sanaa Mohammed El Sadek,3 Rasha Mahmoud Gouda,3 Mohammed Abd El Malik Hassan,4 Amal H Ibrahim,2 Naglaa F Abd El Haliem5 1Clinical Pathology ...
Eldewi DM, Alhabibi AM, El Sayed HME, Mahmoud SAK, El Sadek SM, Gouda RM, Hassan MAEM, Ibrahim AH, Abd El Haliem NF   +8 more
doaj   +2 more sources

Altered expression of complement regulatory proteins CD35 and CD59 in acute lymphoblastic and acute myeloblastic leukemia suggests a context-based pattern [PDF]

Discover Oncology
The complement system is a vital part of the innate immune defense, playing a key role in clearing immune complexes; however, its activity must be carefully regulated to avoid damage to healthy cells.
Reem Hossam EL-Din Ahmed, Menatalla Mostafa Mahmoud, Mohamed Ahmed El-Azizi, Noha Samir Farag   +3 more
doaj   +2 more sources

SARS-CoV-2 nucleocapsid protein forms complexes with soluble complement regulatory proteins that can bind to the virion [PDF]

Scientific Reports
The SARS-CoV-2 nucleocapsid protein has been detected in the plasma of COVID-19 patients, and its levels in the plasma correlate with the severity of the disease. It is also an immunomodulatory protein, triggering the release of proinflammatory cytokines.
Jakub Víglaský, Katarína Bhide, Lea Talpasova, Ľubica Fialová, Mangesh Bhide   +4 more
doaj   +2 more sources