Results 11 to 20 of about 172,719 (244)

SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins [PDF]

Emerging Microbes and Infections
Complement hyperactivation and thrombotic microangiopathy are closely associated with severe COVID-19. Endothelial dysfunction is a key mechanism underlying thrombotic microangiopathy.
Jian Wu, Sanpeng Xu, Zhiqing Li, Boyi Cong, Zongheng Yang, Zhichao Yang, Wanfeng Gao, Shuo Liu, Zhou Yu, Sheng Xu, Nan Li, Jin Hou, Guoping Wang, Xuetao Cao, Shuxun Liu   +14 more
doaj   +2 more sources

Role of complement and complement regulatory proteins in the complications of diabetes.

Endocr Rev, 2015
It is well established that the organ damage that complicates human diabetes is caused by prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels of glucose cause tissue damage in humans are still not fully understood.
Ghosh P, Sahoo R, Vaidya A, Chorev M, Halperin JA.   +4 more
europepmc   +4 more sources

Expression levels of complement regulatory proteins (CD35, CD55 and CD59) on peripheral blood cells of patients with chronic kidney disease [PDF]

International Journal of General Medicine, 2019
Dalia Mahmoud Eldewi,1 Alshaymaa M Alhabibi,1 Hanaa Mohammed Eid El Sayed,2 Sammar Ahmed Kasim Mahmoud,2 Sanaa Mohammed El Sadek,3 Rasha Mahmoud Gouda,3 Mohammed Abd El Malik Hassan,4 Amal H Ibrahim,2 Naglaa F Abd El Haliem5 1Clinical Pathology ...
Eldewi DM, Alhabibi AM, El Sayed HME, Mahmoud SAK, El Sadek SM, Gouda RM, Hassan MAEM, Ibrahim AH, Abd El Haliem NF   +8 more
doaj   +2 more sources

Altered expression of complement regulatory proteins CD35 and CD59 in acute lymphoblastic and acute myeloblastic leukemia suggests a context-based pattern [PDF]

Discover Oncology
The complement system is a vital part of the innate immune defense, playing a key role in clearing immune complexes; however, its activity must be carefully regulated to avoid damage to healthy cells.
Reem Hossam EL-Din Ahmed, Menatalla Mostafa Mahmoud, Mohamed Ahmed El-Azizi, Noha Samir Farag   +3 more
doaj   +2 more sources

Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. [PDF]

PLoS Medicine, 2011
Pregnancy in women with systemic lupus erythematosus (SLE) or antiphospholipid antibodies (APL Ab)--autoimmune conditions characterized by complement-mediated injury--is associated with increased risk of preeclampsia and miscarriage. Our previous studies
Jane E Salmon, Cara Heuser, Michael Triebwasser, M Kathryn Liszewski, David Kavanagh, Lubka Roumenina, D Ware Branch, Tim Goodship, Veronique Fremeaux-Bacchi, John P Atkinson   +9 more
doaj   +3 more sources

SARS-CoV-2 nucleocapsid protein forms complexes with soluble complement regulatory proteins that can bind to the virion [PDF]

Scientific Reports
The SARS-CoV-2 nucleocapsid protein has been detected in the plasma of COVID-19 patients, and its levels in the plasma correlate with the severity of the disease. It is also an immunomodulatory protein, triggering the release of proinflammatory cytokines.
Jakub Víglaský, Katarína Bhide, Lea Talpasova, Ľubica Fialová, Mangesh Bhide   +4 more
doaj   +2 more sources

Complement regulatory proteins are associated with progression rate of geographic atrophy secondary to age-related macular degeneration [PDF]

Immunity & Ageing
Background Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a progressive degenerative disease leading to irreversible vision loss in elderly individuals.
Jenni Martinez Villarruel Hinnerskov, Marie Krogh Nielsen, Alexander Kai Thomsen, Maria Abildgaard Steffensen, Bent Honoré, Henrik Vorum, Mogens Holst Nissen, Torben Lykke Sørensen   +7 more
doaj   +2 more sources

Review: Complement and its regulatory proteins in kidney diseases [PDF]

Nephrology, 2010
ABSTRACTComplement is a part of the body's innate immune system that helps defend the host from microbial infection. It is tightly controlled by a number of cell surface and fluid‐phase proteins so that under normal circumstances injury to autologous tissues is avoided.
Allison M, Lesher, Wen-Chao, Song
exaly   +3 more sources

Upregulation of complement proteins in lung cancer cells mediates tumor progression

Frontiers in Oncology, 2023
IntroductionIn vivo, cancer cells respond to signals from the tumor microenvironment resulting in changes in expression of proteins that promote tumor progression and suppress anti-tumor immunity.
Emily K. Kleczko, Joanna M. Poczobutt, Andre C. Navarro, Jennifer Laskowski, Amber M. Johnson, Sean P. Korpela, Natalia J. Gurule, Lynn E. Heasley, Katharina Hopp, Mary C.M. Weiser-Evans, Elizabeth B. Gottlin, Ryan T. Bushey, Michael J. Campa, Edward F. Patz, Edward F. Patz, Joshua M. Thurman, Raphael A. Nemenoff   +16 more
doaj   +1 more source

The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System

Biomolecules, 2022
The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites.
Sajad Rashidi, Reza Mansouri, Mohammad Ali-Hassanzadeh, Antonio Muro, Paul Nguewa, Raúl Manzano-Román   +5 more
doaj   +1 more source