Results 41 to 50 of about 173,706 (280)

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Dimitrios Stampoulis, M. Francesca Cordeiro, Williams, JA, Jennifer A. E. Williams, Stampoulis, D, Li Guo, Shi, H, Guo, L, Moss, SE, Francesca Cordeiro, M, Stephen E. Moss, Hui Shi   +11 more
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Identification of Complement Regulatory Domains in Vaccinia Virus Complement Control Protein [PDF]

Journal of Virology, 2005
ABSTRACTVaccinia virus encodes a homolog of the human complement regulators named vaccinia virus complement control protein (VCP). It is composed of four contiguous complement control protein (CCP) domains. Previously, VCP has been shown to bind to C3b and C4b and to inactivate the classical and alternative pathway C3 convertases by accelerating the ...
Jayati, Mullick, John, Bernet, Yogesh, Panse, Sharanabasava, Hallihosur, Akhilesh K, Singh, Arvind, Sahu   +5 more
openaire   +2 more sources

Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia. [PDF]

, 2011
BACKGROUND\ud \ud Levels of complement regulatory proteins (CrP) on the surface of red blood cells (RBC) decrease during severe malarial anaemia and as part of cell ageing process.
Fried, Michal, Moses Gwamaka, Michal Fried, Duffy, Patrick E, Patrick E Duffy, Gwamaka, Moses, Gonzalo Domingo, Domingo, Gonzalo   +7 more
core   +1 more source

Profiling Complement System Components in Primary CNS Vasculitis

Cells, 2021
Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji, Christian W. Keller, Simon Koch, Heinz Wiendl, Christian Gerloff, Tim Magnus, Jan D. Lünemann   +6 more
doaj   +1 more source

Function of complement regulatory proteins in immunity of reproduction: a review

Czech Journal of Animal Science, 2005
Humoral immunity has an important role during the maturation and development of the functional properties of spermatozoa. Spermatozoa may be exposed to antisperm antibodies in semen and in cervical, ovarian follicular and fallopian fluid.
J. Valentovičová, M. Simon, J. Antalíková   +2 more
doaj   +1 more source

Involvement of the complement system in immune thrombocytopenia: review of the literature

Immunological Medicine, 2023
Immune thrombocytopenia (ITP) is a thrombocytopenic condition induced by autoimmune mechanisms and includes secondary ITP with underlying diseases such as connective tissue diseases (CTD).
Risa Shindo, Ryohei Abe, Kenji Oku, Tomoki Tanaka, Yu Matsueda, Tatsuhiko Wada, Yoshiyuki Arinuma, Sumiaki Tanaka, Tatsuyoshi Ikenoue, Yoshitaka Miyakawa, Kunihiro Yamaoka   +10 more
doaj   +1 more source

On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni. [PDF]

PLoS Neglected Tropical Diseases, 2013
It is believed that schistosomes evade complement-mediated killing by expressing regulatory proteins on their surface. Recently, six homologues of human CD59, an important inhibitor of the complement system membrane attack complex, were identified in the
Leonardo P Farias, Greice Krautz-Peterson, Cibele A Tararam, Bogar O Araujo-Montoya, Tatiana R Fraga, Henrique K Rofatto, Floriano P Silva, Lourdes Isaac, Akram A Da'dara, R Alan Wilson, Charles B Shoemaker, Luciana C C Leite   +11 more
doaj   +1 more source

Complement regulatory proteins and autoimmunity

Autoimmunity, 2006
The complement system is known to be involved in autoimmunity at several levels. Activated complement contributes to the inflammatory tissue injury characteristic of many autoimmune disease settings. On the other hand, early components of the classical pathway, including C1q, C4 and C2, are thought to be important for disposing apoptotic cellular ...
openaire   +2 more sources

Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants

Journal of Translational Medicine, 2020
Background Complement Regulatory Proteins (CRPs), especially CD55 primarily negate complement factor 3-mediated injuries and maintain tissue homeostasis during complement cascade activation.
Mohammad Afzal Khan, Talal Shamma, Shadab Kazmi, Abdullah Altuhami, Hala Abdalrahman Ahmed, Abdullah Mohammed Assiri, Dieter Clemens Broering   +6 more
doaj   +1 more source

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity

, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Schott, Melanie, Sonja Grosskinsky, Markus M. Simon, Grosskinsky, Sonja, Cutler, Sally J., Schott, M., Simon, M., Kraiczy, P., Zipfel, Peter F., Grosskinsky, S., Peter Kraiczy, Sally J Cutler, Peter F Zipfel, Peter F. Zipfel, Brenner, Christiane, Wallich, R., Kraiczy, Peter, Brenner, C., Christiane Brenner, Simon, Markus M., Markus M Simon, Wallich, Reinhard, Sally J. Cutler, Reinhard Wallich, Cutler, S., Zipfel, P., Melanie Schott   +26 more
core   +1 more source