Results 31 to 40 of about 172,719 (244)
Identification of Complement Regulatory Domains in Vaccinia Virus Complement Control Protein [PDF]
Journal of Virology, 2005 ABSTRACTVaccinia virus encodes a homolog of the human complement regulators named vaccinia virus complement control protein (VCP). It is composed of four contiguous complement control protein (CCP) domains. Previously, VCP has been shown to bind to C3b and C4b and to inactivate the classical and alternative pathway C3 convertases by accelerating the ...
Jayati, Mullick +5 more
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Function of complement regulatory proteins in immunity of reproduction: a review
Czech Journal of Animal Science, 2005 Humoral immunity has an important role during the maturation and development of the functional properties of spermatozoa. Spermatozoa may be exposed to antisperm antibodies in semen and in cervical, ovarian follicular and fallopian fluid.
J. Valentovičová +2 more
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Profiling Complement System Components in Primary CNS Vasculitis
Cells, 2021 Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji +6 more
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Involvement of the complement system in immune thrombocytopenia: review of the literature
Immunological Medicine, 2023 Immune thrombocytopenia (ITP) is a thrombocytopenic condition induced by autoimmune mechanisms and includes secondary ITP with underlying diseases such as connective tissue diseases (CTD).
Risa Shindo +10 more
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Complement regulatory proteins and autoimmunity
Autoimmunity, 2006 The complement system is known to be involved in autoimmunity at several levels. Activated complement contributes to the inflammatory tissue injury characteristic of many autoimmune disease settings. On the other hand, early components of the classical pathway, including C1q, C4 and C2, are thought to be important for disposing apoptotic cellular ...
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Complement regulatory proteins in glomerular diseases [PDF]
Kidney International, 1998 Complement activation plays a critical role in the pathogenesis of many forms of glomerulonephritis. Complement activation leads to tissue injury through various mechanisms including the generation of chemotactic factors and activation of the resident glomerular cells following C5b-9 insertion.
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Journal of Translational Medicine, 2020 Background Complement Regulatory Proteins (CRPs), especially CD55 primarily negate complement factor 3-mediated injuries and maintain tissue homeostasis during complement cascade activation.
Mohammad Afzal Khan +6 more
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On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni. [PDF]
PLoS Neglected Tropical Diseases, 2013 It is believed that schistosomes evade complement-mediated killing by expressing regulatory proteins on their surface. Recently, six homologues of human CD59, an important inhibitor of the complement system membrane attack complex, were identified in the
Leonardo P Farias +11 more
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Antibodies against complement-regulatory proteins on platelets in immune thrombocytopenia
Platelets, 2017 In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding.
Ursula Unterberger +3 more
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The Complement System: A Prey of Trypanosoma cruzi
Frontiers in Microbiology, 2017 Trypanosoma cruzi is a protozoan parasite known to cause Chagas disease (CD), a neglected sickness that affects around 6–8 million people worldwide. Originally, CD was mainly found in Latin America but more recently, it has been spread to countries in ...
Kárita C. F. Lidani +3 more
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