Results 21 to 30 of about 544,854 (305)

Local Activation of the Alternative Pathway of Complement System in Mycotic Keratitis Patient Tear

Frontiers in Cellular and Infection Microbiology, 2020
Aspergillus flavus and Fusarium solani are the predominant causative agents of mycotic keratitis in the tropical part of the world. Tear proteins play a major role in the innate immune response against these fungal infections as has been shown by the ...
Mohammed Razeeth Shait Mohammed, Sandhya Krishnan, Rabbind Singh Amrathlal, Jeya Maheshwari Jayapal, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Dharmalingam Kuppamuthu   +6 more
doaj   +1 more source

Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes [PDF]

, 2015
Specific co-chaperone adaptors facilitate the recruitment of client proteins to the Hsp90 system. Tah1 binds the C-terminal conserved MEEVD motif of Hsp90, thus linking an eclectic set of client proteins to the R2TP complex for their assembly and ...
Ali, Back, Battye, Boulon, Chartron, Chrisostomos Prodromou, Eckert, Emsley, Forget, Gonzales, Hořejší, Itsuki, Izumi, Jiménez, Kakihara, Krissinel, Kurokawa, Laurence H. Pearl, Liou, Liu, Mohinder Pal, Morgan, Murshudov, Nagradova, Nyarko, Pal, Pearl, Polier, Prodromou, Prodromou, Rhodri M. L. Morgan, Roe, S. Mark Roe, Samarsky, Siligardi, Takai, Te, Tobaben, Tung, Vaughan, Worrall, Zhang, Zhao   +42 more
core   +1 more source

Rat C‐reactive protein activates the autologous complement system

Immunology, 2003
SummaryActivation of complement is a biological function of human C‐reactive protein (hCRP), whereas rat CRP (rCRP) has been claimed to be unable to activate complement. As important biological functions of proteins are probably conserved among species, we re‐evaluated, using various ligands, the capability of rCRP to activate complement.
Niubel, Diaz Padilla, Wim K, Bleeker, Yvonne, Lubbers, Gemma M M, Rigter, Gerard J, Van Mierlo, Mohamed R, Daha, C Erik, Hack   +6 more
openaire   +3 more sources

Implications of Complement Imbalance in COVID-19: A Molecular Mechanistic Discussion on the Importance of Complement Balance [PDF]

Iranian Journal of Immunology, 2023
Two central questions in COVID-19 treatment which should be considered are: “How does the imbalance of the complement system affect the therapeutic approaches?” and “Do we consider complement inhibitors in therapeutic protocols?”.
Mehdi Torabizadeh, Helia Modaresi Asfeh, Zeinab Deris Zayeri, Cerdan Dominique, Hashem Kazemi, Najmaldin Saki   +5 more
doaj   +1 more source

Biosynthetic homeostasis and resilience of the complement system in health and infectious diseaseResearch in context

EBioMedicine, 2019
Background: The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis.
Esther Willems, Wynand Alkema, Jenneke Keizer-Garritsen, Anouk Suppers, Michiel van der Flier, Ria H.L.A. Philipsen, Lambert P. van den Heuvel, Elena Volokhina, Renate G. van der Molen, Jethro A. Herberg, Michael Levin, Victoria J. Wright, Inge M.L. Ahout, Gerben Ferwerda, Marieke Emonts, Navin P. Boeddha, Irene Rivero-Calle, Federico Martinon Torres, Hans J.C.T. Wessels, Ronald de Groot, Alain J. van Gool, Jolein Gloerich, Marien I. de Jonge   +22 more
doaj   +1 more source

Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity

Frontiers in Immunology, 2022
The complement system is a part of the innate immune system, where it labels intruding pathogens as well as dying host cells for clearance. If complement regulation is compromised, the system may contribute to pathogenesis.
Henrik Pedersen, Rasmus Kjeldsen Jensen, Annette Gudmann Hansen, Steen Vang Petersen, Steffen Thiel, Nick Stub Laursen, Nick Stub Laursen, Gregers Rom Andersen   +7 more
doaj   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M, Kishore, U, Kouser, L, Nayak, A, Sim, RB, Stover, CM   +5 more
core   +1 more source

Borrelia burgdorferi Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts. [PDF]

, 2017
Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of ...
Baumgarth, Nicole, Tracy, Karen E
core   +1 more source

COMPLEMENT SYSTEM PROTEIN C4 AND SUSCEPTIBILITY TO HYDRALAZINE-INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS

The Lancet, 1989
21 patients with systemic lupus erythematosus induced by long-term treatment with hydralazine were investigated to see whether susceptibility to this syndrome was associated with deficiency of the classical pathway complement protein, C4. 16 of 21 (76%) patients had one or more C4 null (ie, non-productive) alleles compared with 35 of 82 normal subjects
Speirs, C, Fielder, A, Chapel, H, Davey, N, Batchelor, JR   +4 more
openaire   +3 more sources

Synovial fibroblast‐like cells synthesize seven proteins of the complement system [PDF]

Arthritis & Rheumatism, 1988
AbstractFibroblast‐like cells from synovial tissue obtained during arthroscopy in 4 young adults with recent knee trauma were biosynthetically labeled with 35S‐methionine, and protein production was quantitated by immunoprecipitation and sodium dodecyl sulfate—polyacrylamide gel electrophoresis.
Y, Katz, R C, Strunk
openaire   +2 more sources