Results 21 to 30 of about 325,997 (305)

Membrane Protein Crry Maintains Homeostasis of the Complement System [PDF]

The Journal of Immunology, 2008
Abstract Complement activation is tightly regulated to avoid excessive inflammatory and immune responses. Crry−/− is an embryonic lethal phenotype secondary to the maternal complement alternative pathway (AP) attacking a placenta deficient in this inhibitor. In this study, we demonstrate that Crry−/− mice could be rescued on a partial
Xiaobo, Wu, Dirk, Spitzer, Dailing, Mao, Stanford L, Peng, Hector, Molina, John P, Atkinson   +5 more
openaire   +2 more sources

The Role of Complement in Cancer Immunotherapy [PDF]

, 2022
The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...

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Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström, Peter F. Zipfel, Zipfel, Peter F, Christine Skerka, Hallström, Teresia, Kraiczy, Peter, Skerka, Christine, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Zipfel, Peter F., Reinhard Wallich, Peter Kraiczy, Stevenson, Brian, Brian Stevenson   +14 more
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The complement system of the goat: Haemolytic assays and isolation of major proteins [PDF]

BMC Veterinary Research, 2012
AbstractBackgroundThe aim of the present study was to develop a haemolytic assay for the study of the complement system in dairy goats (Capra aegagrus hircus) and to characterize the major goat complement system proteins.ResultsThe commonly used sheep erythrocyte sensitized with rabbit antibodies were not sensitive to lysis by goat serum, but the ...
Moreno-Indias, Isabel, Dodds, Alister W., Argüello Henríquez, Anastasio, Castro Navarro, Noemí, Sim, Robert B.   +4 more
openaire   +4 more sources

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Sim, Robert B., Sloan, Jeremy, Green, Malcolm L.H., Sim, Edith, Salvador-Morales, Carolina, Green, Malcolm L. H.   +6 more
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INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEM [PDF]

The Journal of Experimental Medicine, 1974
Protamine sulfate was found to consume large amounts of C selectively during preincubation with sera of individuals in the "acute phase". Marked depletion of C1, C4, and C2 with minimal, if any, depletion of C3-9, was observed. The consumption was time and temperature dependent, occurring most rapidly and extensively at 37°C, 0.10 M relative salt ...
Joan Siegel, Rosemarie Rent, Henry Gewurz   +2 more
openaire   +1 more source

Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4 [PDF]

, 2010
Background: B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. Spirochetes have adapted themselves to the human immune system in many distinct ways.
Peter F. Zipfel, Dam, A.P. van, Schuijt, Tim J., Kraiczy, Peter, Nathalie D. van Burgel, Nathalie D. van Burgel, van Dam, Alje P., van Burgel Nathalie D, Burgel, N.D. van, Burgel, Nathalie D. van, Schuijt Tim J, Tim J. Schuijt, Kraiczy Peter, Schuijt, T.J., van Dam Alje P, Zipfel Peter F, Kraiczy, P., Zipfel, Peter F., Alje P. van Dam, Peter Kraiczy, Zipfel, P.F., Dam, Alje P. van, van Burgel, Nathalie D.   +22 more
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Complement Fixation in the C-reactive Protein System

Experimental Biology and Medicine, 1954
SummaryA complement fixation method based on the reaction between CRP in human test sera and rabbit CRP antisera has been described.
L H, MUSCHEL, R J, WEATHERWAX
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Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Kouser, L, Cordula M. Stover, Munirah Abdul-Aziz, Robert B. Sim, Nayak, A, Lubna Kouser, L. Kouser (7639589), Kishore, U, M. Abdul-Aziz (7677725), R. B. Sim (7584038), U. Kishore (7639601), Cordula M. Stover (7117046), Abdul-Aziz, M, Annapurna Nayak, A. Nayak (7334981), Stover, CM, Sim, RB, Uday Kishore   +17 more
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Lectin pathway proteins of the complement system in normotensive pregnancy and pre‐eclampsia [PDF]

American Journal of Reproductive Immunology, 2019
ProblemThe lectin pathway of the complement system may be involved in the pathogenesis of pre‐eclampsia. We aimed to investigate changes in serum concentrations of a broad range of lectin pathway proteins during normal pregnancy and their association with pre‐eclampsia, placental infarctions and intrauterine growth restriction (IUGR).Method of studyWe ...
Julie Brogaard Larsen, Anita Sylvest Andersen, Christine Lodberg Hvas, Steffen Thiel, Michael Rud Lassen, Anne‐Mette Hvas, Anette Tarp Hansen   +6 more
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