Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host
Frontiers in Microbiology, 2019 Parasitic infections induce host immune responses that eliminate the invading parasites. However, parasites have evolved to develop many strategies to evade host immune attacks and survive in a hostile environment. The complement system acts as the first
Shuai Shao +4 more
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INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEM [PDF]
The Journal of Experimental Medicine, 1974 Protamine sulfate was found to consume large amounts of C selectively during preincubation with sera of individuals in the "acute phase". Marked depletion of C1, C4, and C2 with minimal, if any, depletion of C3-9, was observed. The consumption was time and temperature dependent, occurring most rapidly and extensively at 37°C, 0.10 M relative salt ...
Joan Siegel +2 more
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Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4 [PDF]
, 2010 Background: B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. Spirochetes have adapted themselves to the human immune system in many distinct ways.
Peter F. Zipfel +22 more
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Local Activation of the Alternative Pathway of Complement System in Mycotic Keratitis Patient Tear
Frontiers in Cellular and Infection Microbiology, 2020 Aspergillus flavus and Fusarium solani are the predominant causative agents of mycotic keratitis in the tropical part of the world. Tear proteins play a major role in the innate immune response against these fungal infections as has been shown by the ...
Mohammed Razeeth Shait Mohammed +6 more
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Complement Fixation in the C-reactive Protein System
Experimental Biology and Medicine, 1954 SummaryA complement fixation method based on the reaction between CRP in human test sera and rabbit CRP antisera has been described.
L H, MUSCHEL, R J, WEATHERWAX
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Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]
, 2013 This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Kouser, L +17 more
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The Role of Complement in Tumors [PDF]
, 2020 The complement system is an essential part of the innate immune system that is responsible for regulating inflammation, facilitating immune defense mechanisms, and maintaining tissue homeostasis.
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Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]
, 2013 Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Christine Skerka +24 more
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EBioMedicine, 2019 Background: The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis.
Esther Willems +22 more
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Implications of Complement Imbalance in COVID-19: A Molecular Mechanistic Discussion on the Importance of Complement Balance [PDF]
Iranian Journal of Immunology, 2023 Two central questions in COVID-19 treatment which should be considered are: “How does the imbalance of the complement system affect the therapeutic approaches?” and “Do we consider complement inhibitors in therapeutic protocols?”.
Mehdi Torabizadeh +5 more
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