Results 31 to 40 of about 246,489 (273)
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Acute liver failure (ALF) is a life-threatening condition with limited treatment alternatives. ALF pathogenesis seemingly involves the complement system. However, no complement-targeted intervention has been clinically applied.
Jiro Kusakabe +11 more
doaj +1 more source
Requirements for membrane attack complex formation and anaphylatoxins binding to collagen-activated platelets. [PDF]
PLoS ONE, 2011 The activation of complement during platelet activation is incompletely understood.We sought to explore the formation of C5b-9 and anaphylatoxins binding to collagen-activated platelets.C5b-9, anaphylatoxins C3a, C4a and C5a, and anaphylatoxin receptors ...
Catherine Martel +6 more
doaj +1 more source
Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators. [PDF]
, 2013 Reaction coordinate diagrams are used to relate the free energy changes that occur during the progress of chemical processes to the rate and equilibrium constants of the process.
Scholey, Jonathan M
core +2 more sources
Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models
Acta Neuropathologica Communications, 2022 Complement is involved in developmental synaptic pruning and pathological synapse loss in Alzheimer’s disease. It is posited that C1 binding initiates complement activation on synapses; C3 fragments then tag them for microglial phagocytosis. However, the
Sarah M. Carpanini +10 more
doaj +1 more source
The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]
, 2018 The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J +4 more
core +1 more source
eLife, 2022 The membrane attack complex (MAC or C5b-9) is an important effector of the immune system to kill invading microbes. MAC formation is initiated when complement enzymes on the bacterial surface convert complement component C5 into C5b.
Dennis J Doorduijn +7 more
doaj +1 more source
The inflammatory process of gout and its treatment. [PDF]
, 2006 Gouty arthritis is a characteristically intense acute inflammatory reaction that erupts in response to articular deposits of monosodium urate (MSU) crystals.
Cronstein, Bruce N, Terkeltaub, Robert
core +2 more sources
Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin [PDF]
, 2014 Membrane attack complex/perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins constitute a major superfamily of pore-forming proteins that act as bacterial virulence factors and effectors in immune defence.
Baker +42 more
core +3 more sources
Research progress of perforin 2 [PDF]
Jichu yixue yu linchuangPerforin 2 (MPEG 1) is a member of the MACPF(membrane attack complex/PRF membrane attack complex/perforin) superfamily, which is mainly secreted by cytotoxic T lymphocytes, natural killer cells and macrophages Through the formation of active pores on the
DENG Zhiyuan, BAI Lu, YU Rong
doaj +1 more source
Bacterial killing by complement requires membrane attack complex formation via surface-bound C5 convertases. [PDF]
EMBO J, 2019 Heesterbeek DA +10 more
europepmc +2 more sources