Results 31 to 40 of about 111,621 (234)

Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Effect Complement-Mediated Neurotoxicity

Cells, 2020
We have previously shown that blood astrocytic-origin extracellular vesicles (AEVs) from Alzheimer’s disease (AD) patients contain high complement levels.
Carlos J. Nogueras-Ortiz, Vasiliki Mahairaki, Francheska Delgado-Peraza, Debamitra Das, Konstantinos Avgerinos, Erden Eren, Matthew Hentschel, Edward J. Goetzl, Mark P. Mattson, Dimitrios Kapogiannis   +9 more
doaj   +1 more source

Complement-5 Inhibition Deters Progression of Fulminant Hepatitis to Acute Liver Failure in Murine ModelsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Acute liver failure (ALF) is a life-threatening condition with limited treatment alternatives. ALF pathogenesis seemingly involves the complement system. However, no complement-targeted intervention has been clinically applied.
Jiro Kusakabe, Koichiro Hata, Hidetaka Miyauchi, Tetsuya Tajima, Yi Wang, Ichiro Tamaki, Junya Kawasoe, Yusuke Okamura, Xiangdong Zhao, Tatsuya Okamoto, Tatsuaki Tsuruyama, Shinji Uemoto   +11 more
doaj   +1 more source

Requirements for membrane attack complex formation and anaphylatoxins binding to collagen-activated platelets. [PDF]

PLoS ONE, 2011
The activation of complement during platelet activation is incompletely understood.We sought to explore the formation of C5b-9 and anaphylatoxins binding to collagen-activated platelets.C5b-9, anaphylatoxins C3a, C4a and C5a, and anaphylatoxin receptors ...
Catherine Martel, Sylvie Cointe, Pascal Maurice, Saïd Matar, Marta Ghitescu, Pierre Théroux, Arnaud Bonnefoy   +6 more
doaj   +1 more source

Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models

Acta Neuropathologica Communications, 2022
Complement is involved in developmental synaptic pruning and pathological synapse loss in Alzheimer’s disease. It is posited that C1 binding initiates complement activation on synapses; C3 fragments then tag them for microglial phagocytosis. However, the
Sarah M. Carpanini, Megan Torvell, Ryan J. Bevan, Robert A. J. Byrne, Nikoleta Daskoulidou, Takashi Saito, Takaomi C. Saido, Philip R. Taylor, Timothy R. Hughes, Wioleta M. Zelek, B. Paul Morgan   +10 more
doaj   +1 more source

Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5

eLife, 2022
The membrane attack complex (MAC or C5b-9) is an important effector of the immune system to kill invading microbes. MAC formation is initiated when complement enzymes on the bacterial surface convert complement component C5 into C5b.
Dennis J Doorduijn, Marie V Lukassen, Marije FL van 't Wout, Vojtech Franc, Maartje Ruyken, Bart W Bardoel, Albert JR Heck, Suzan HM Rooijakkers   +7 more
doaj   +1 more source

Research progress of perforin 2 [PDF]

Jichu yixue yu linchuang
Perforin 2 (MPEG 1) is a member of the MACPF(membrane attack complex/PRF membrane attack complex/perforin) superfamily, which is mainly secreted by cytotoxic T lymphocytes, natural killer cells and macrophages Through the formation of active pores on the
DENG Zhiyuan, BAI Lu, YU Rong
doaj   +1 more source

Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice

Journal of Neuroinflammation, 2010
Background The complement system is a crucial mediator of inflammation and cell lysis after cerebral ischemia. However, there is little information about the exact contribution of the membrane attack complex (MAC) and its inhibitor-protein CD59.
Nietfeld Wilfried, Dirnagl Ulrich, Morgan B Paul, Stahel Philip F, Khojasteh Uldus, Harhausen Denise, Trendelenburg George   +6 more
doaj   +1 more source

To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins

Frontiers in Immunology, 2020
Pore-forming proteins (PFPs) are present in all domains of life, and play an important role in host-pathogen warfare and in the elimination of cancers.
Patrycja A. Krawczyk, Marco Laub, Patrycja Kozik   +2 more
doaj   +1 more source

Structure of the poly-C9 component of the complement membrane attack complex

Nature Communications, 2016
The membrane attack complex is a heteromeric assembly of complement proteins where multiple copies of C9 are recruited by the C5b678 complex to form lytic pores in pathogen membranes.
Natalya V. Dudkina, Bradley A. Spicer, Cyril F. Reboul, Paul J. Conroy, Natalya Lukoyanova, Hans Elmlund, Ruby H. P. Law, Susan M. Ekkel, Stephanie C. Kondos, Robert J. A. Goode, Georg Ramm, James C. Whisstock, Helen R. Saibil, Michelle A. Dunstone   +13 more
doaj   +1 more source

Membrane Attack Complex and Factor H in Humans with Acute Kidney Injury

Kidney & Blood Pressure Research, 2018
Background and Aims: Complement system seems to play an important role in the pathogenesis of Acute Kidney Injury (AKI). The aim of this study was to investigate the role of complement system in the pathogenesis of human AKI. For this purpose, we studied
Eva Rodríguez, Javier Gimeno, Carlos Arias-Cabrales, Clara Barrios, Dolores Redondo- Pachón, María José Soler, Marta Crespo, Adriana Sierra-Ochoa, Marta Riera, Julio Pascual   +9 more
doaj   +1 more source