Results 1 to 10 of about 33,694 (246)
Structural basis of complement membrane attack complex formation [PDF]
Nature Communications, 2016 The membrane attack complex (MAC) is an immune effector that kills pathogens by forming pores in their membrane. Here the authors use cryo-electron microscopy to reveal that the full MAC is an asymmetric pore with a split-washer configuration and ...
Marina Serna +3 more
doaj +5 more sources
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers [PDF]
Nature Communications, 2018 The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to ...
Anaïs Menny +8 more
doaj +3 more sources
Structure of the poly-C9 component of the complement membrane attack complex [PDF]
Nature Communications, 2016 The membrane attack complex is a heteromeric assembly of complement proteins where multiple copies of C9 are recruited by the C5b678 complex to form lytic pores in pathogen membranes.
Natalya V. Dudkina +13 more
doaj +3 more sources
The mystery behind membrane insertion: a review of the complement membrane attack complex. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2017 The membrane attack complex (MAC) is an important innate immune effector of the complement terminal pathway that forms cytotoxic pores on the surface of microbes. Despite many years of research, MAC structure and mechanism of action have remained elusive,
Bayly-Jones C, Bubeck D, Dunstone MA.
europepmc +6 more sources
Structural basis of soluble membrane attack complex packaging for clearance [PDF]
Nature Communications, 2021 To prevent unregulated complement activation, extracellular chaperones capture soluble precursors to the membrane attack complex (sMAC). Here, structural analysis of sMAC reveals how clusterin recognizes heterogeneous sMAC complexes and inhibits ...
Anaïs Menny +5 more
doaj +3 more sources
Quantitative Analysis of Complement Membrane Attack Complex Proteins Associated with Extracellular Vesicles [PDF]
ProteomesExtracellular vesicles (EVs) represent a universal mechanism of intercellular communication in normal and pathological conditions. There are reports showing the presence of complement proteins in EV preparations, specifically those that can form a ...
Illarion V. Turko
doaj +2 more sources
Design of miniprotein inhibitors targeting complement C9 to block membrane attack complex assembly [PDF]
Nature CommunicationsThe abnormal formation of the membrane attack complex (MAC) is intrinsically linked to a range of acute and chronic immune diseases. The insertion of complement C9 into the membrane is the final step and kinetic bottleneck of MAC formation.
Min Li +16 more
doaj +2 more sources
eLife, 2022 The membrane attack complex (MAC or C5b-9) is an important effector of the immune system to kill invading microbes. MAC formation is initiated when complement enzymes on the bacterial surface convert complement component C5 into C5b.
Dennis J Doorduijn +7 more
doaj +1 more source
Frontiers in Neuroscience, 2023 BackgroundThe autoantibody to myelin oligodendrocyte glycoprotein (MOG), a component of the central nervous system myelin, has been identified in a subset of demyelinating diseases.
Kuniko Kohyama +5 more
doaj +1 more source
Journal of Innate Immunity, 2022 Damage and disease of nerves activates the complement system. We demonstrated that activation of the terminal pathway of the complement system leads to the formation of the membrane attack complex (MAC) and delays regeneration in the peripheral nervous ...
Heidi Gytz Olesen +17 more
doaj +1 more source